Liquisolid Technique for Ibuprofen Tablet

Abstract

Ibuprofen is a drug with poor solubility in water but good permeability in the gastrointestinal tract. Liquisolid tablet is one method of increasing solubility and dissolution rate s of ibuprofen. The aim of this study is to determine the effects of glycerine, PEG 400, and propylene glycol as a non-volatile solvent and HPMC K4M as a hydrophilic polymer in order to understand the dissolution rates of ibuprofen liquisolid tablets. In this research, 10 formulas of ibuprofen liquisolid tablets were made. The ratio of ibuprofen in glycerinee is 3:1; in PEG 400 and in propylene glycol is 5:1 with various concentration of HPMC K4M (2.5, 5 and 10 %). Formula non liquisolid was made as a control, so there was no addition of non-volatile solvent and hydrophilic polymer. Based on the results, ibuprofen liquisolid tablets that use glycerine, PEG400 or propylene glycol as the non-volatile solvent and HPMC K4M as the hydrophilic polymer can increase the dissolution rate constant of ibuprofen compared with non liquisolid ibuprofen tablets. The addition of HPMC K4M can increase the dissolution rate constant of ibuprofen liquisolid tablets until concentration of less than 2.5 % in glycerine; in PEG 400 can increase the dissolution rate constant of ibuprofen liquisolid tablets until concentration up to 5 % and in propylene glycol can increase the dissolution rate constant of ibuprofen until concentration up to 10 % because the polymer will swell and form a viscous layer that inhibits the disintegration; therefore, the percent release is decreasing.