Abstract. Automata over infinite words provide a powerful framework to solve various decision problems. However, the mechanized reasoning with restricted classes of automata over infinite words is often simpler and more efficient. For instance, weak deterministic Büchi automata (wdbas) can be handled algorithmically almost as efficient as deterministic automata over finite words. In this paper, we show how and when the standard powerset construction for automata over finite words can be used to determinize automata over infinite words. An instance is the class of automata that accept wdba-recognizable languages. Furthermore, we present applications of this new determinization construction. Namely, we apply it to improve the automata-based approach for the mixed firstorder linear arithmetic over the reals and the integers, and we utilize it to accelerate finite state model checking. We report on experimental results for these two applications.