“…The early generation of angiotensin converting enzyme inhibitors include (a) captopril, (b) enalapril, (c) enalaprilat and (d) lisinopril with varying degrees of inhibition characteristics toward ACE (4)(5)(6). Extensive quantitative autoradiographic studies performed on lisinopril by Weber et al (7)(8)(9) revealed that high density binding of ACE is localized in the sites of high collagen heart valve leaflets after myocardial infarction.…”