List of Contributors

Bacani, Rebeca; Moraes, Thaisa Brandão Ferreira; Politi, Mário José; Triboni, Eduardo Rezende; Trindade, Fabiane J.

doi:10.1016/b978-0-12-814825-9.00015-1

Cited by 4 publications

(5 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…During the self-assembly, hydrogen bonding, π−π stacking, electrostatic interactions, dipole-dipole interactions, van der Waals interactions, and metal-to-ligand coordination between the gelators play important roles. Meanwhile, gelator-solvent interactions are able to subtly regulate these interactions and thus make the gel system a good platform for the fabrication of well-defined stimuli-responsive or smart soft materials [24,63].…”

Section: Sol-gel and Supramolecular Aspects Applied In Polyureasmentioning

confidence: 99%

Polyureas Versatile Polymers for New Academic and Technological Applications

et al. 2021

View full text Add to dashboard Cite

Polyureas (PURs) are a competitive polymer to their analogs, polyurethanes (PUs). Whereas PUs’ main functional group is carbamate (urethane), PURs contain urea. In this revision, a comprehensive overview of PUR properties, from synthesis to technical applications, is displayed. Preparative routes that can be used to obtain PURs using diisocianates or harmless reagents such as CO2 and NH3 are explained, and aterials, urea monomers and PURs are discussed; PUR copolymers are included in this discussion as well. Bulk to soft components of PUR, as well as porous materials and meso, micro or nanomaterials are evaluated. Topics of this paper include the general properties of aliphatic and aromatic PUR, followed by practical synthetic pathways, catalyst uses, aggregation, sol–gel formation and mechanical aspects.

show abstract

Section: Sol-gel and Supramolecular Aspects Applied In Polyureasmentioning

confidence: 99%

Polyureas Versatile Polymers for New Academic and Technological Applications

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Completely transparent gels were formed by enantiopure samples of compounds 1, 11, 14. 3 Denotes no gelation; solution or precipitate formed. 4 Ref.…”

Section: Gelation Abilities Of Compounds 1-14 and Some Gel Characterimentioning

confidence: 99%

“…Since then, this number has only increased. So, over the past 10 years, several monographs have been published on this topic [3][4][5][6]. Many reviews highlight the current state of the subject [2,7,8], instrumental methods for the study of SMG [9,10], the structure of supramolecular associates arising in the gelling process [11,12], the relationship between gelation and the solvent's nature [13], progress in the design of new LMWG [14][15][16], and the realized and potential use of SMG in practice [17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Chirality, Gelation Ability and Crystal Structure: Together or Apart? Alkyl Phenyl Ethers of Glycerol as Simple LMWGs

et al. 2021

View full text Add to dashboard Cite

Chiral recognition plays an important role in the self-assembly of soft materials, in particular supramolecular organogels formed by low molecular weight gelators (LMWGs). Out of 14 pairs of the studied racemic and enantiopure samples of alkyl-substituted phenyl ethers of glycerol, only eight enantiopure diols form the stable gels in nonane. The formation of gels from solutions was studied by polarimetry, and their degradation with the formation of xerogels was studied by the PXRD method. The revealed crystalline characteristics of all studied xerogels corresponded to those for crystalline samples of the parent gelators. In addition to those previously investigated, crystalline samples of enantiopure para-n-alkylphenyl glycerol ethers [alkyl = pentyl (5), hexyl (6), heptyl (7), octyl (8), nonyl (9)] and racemic 3-(3,5-dimethylphenoxy)propane-1,2-diol (rac-14) have been examined by single crystal X-ray diffraction analysis. Among 22 samples of compounds 1-14 studied by SC-XRD, seven different types of supramolecular motifs are identified, of which only two are realized in crystals of supramolecular gelators. An attempt was made to relate the ability to gel formation with the characteristics of the supramolecular motif of a potential gelling agent, and the frequency of formation of the motif, required for gelation, with the chiral characteristics of the sample.

show abstract

“…Supramolecular organo/hydrogels developed from tiny molecules have been an interesting topic of research because of their intrinsic biocompatibility for which they have been touted as an ideal replacement for a chemical gel (a polymeric gel). On exposure to external stimulus, gels exhibit fine-tuning in molecular-level interactions, rendering them a versatile and soft material with the potential to be employed in a wide range of applications such as drug delivery, bone repair, wound healing, tissue engineering, cosmetics, sensors, and imaging. − The phase shift from sol to gel and vice versa can be triggered by external factors as gels made from tiny molecules are dynamically reversible. Gaining insight into this phenomenon has the potential to pave the way for enhanced applications, particularly in the realms of drug delivery and the creation of devices with memory functions that can be toggled …”

Section: Introductionmentioning

confidence: 99%

Supramolecular Organo/hydrogel-Fabricated Long Alkyl Chain α-Amidoamides as a Smart Soft Material for pH-Responsive Curcumin Release

Sebastian,

Rohila,

Yadav

et al. 2024

Biomacromolecules

View full text Add to dashboard Cite

Low-molecular-mass gelators, due to their excellent biocompatibility, low toxicological profile, innate biodegradability and ease of fabrication have garnered significant interest as they self-assemble through non-covalent interactions. In this study, we have designed and synthesized a series of six α-amidoamides by varying the hydrophobic alkyl chain length (C 12 −C 22 ), which were well characterized using different spectral techniques. These α-amidoamides formed self-assembled aggregates in a DMSO/water solvent system affording organo/hydrogels at 0.66% w/v, which is the minimum gelation concentration (MGC) making them as remarkable supergelators. The various functionalities present in these gelators such as amides and alkyl chain length pave the way toward excellent gelation mechanism through hydrogen bonding and van der Waals interaction as evidenced from FTIR spectroscopy. Notably, as the chain length increased, organo/hydrogels became more thermally stable. Rheological results showed that the stability and strength of these gelators were considerably impacted by variations in chain length. The SEM morphology revealed dense sheet architectures of the organo/hydrogel samples. Organo/hydrogels have a significant impact on the advancement of innovative drug delivery systems that respond to various stimuli, ushering in a new era in pharmaceutical technology. Inspired by this, we encapsulated curcumin, a chemopreventive medication, into the gel core and further released via gel-to-sol transition induced by pH variation at 37 °C, without any alteration in structure−activity relationship. The drug release behavior was observed by UV−vis spectroscopy. Moreover, cell viability and cell invasion experiments demonstrate that the gel formulations exhibit high biocompatibility and low cytotoxicity. Among the tested formulations, 5e+Cur exhibited remarkable efficacy in controlling A549 cell migration, suggesting significant potential for applications in the pharmaceutical industry.

show abstract

List of Contributors

Cited by 4 publications

References 0 publications

Polyureas Versatile Polymers for New Academic and Technological Applications

Polyureas Versatile Polymers for New Academic and Technological Applications

Chirality, Gelation Ability and Crystal Structure: Together or Apart? Alkyl Phenyl Ethers of Glycerol as Simple LMWGs

Supramolecular Organo/hydrogel-Fabricated Long Alkyl Chain α-Amidoamides as a Smart Soft Material for pH-Responsive Curcumin Release

Contact Info

Product

Resources

About