Listeriosis Complicating Malignant Disease

Louria, Donald B.

doi:10.7326/0003-4819-67-2-261

Cited by 170 publications

(73 citation statements)

References 62 publications

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“…In 1967, Louria et al first described an association between listeriosis and malignant disease (94), and more recent reviews suggest that most invasive listeriosis occurs in persons who are immunosuppressed or elderly (111,122,147 (147). The most common conditions were cancer (23%), diabetes (20%), renal disease (18%), and heart disease (17%); several patients had more than one underlying condition.…”

Section: Monocytogenes In Humans Carriagementioning

confidence: 99%

The epidemiology of human listeriosis

Swaminathan¹,

Gerner‐Smidt²

2007

Microbes and Infection

1,033

744

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Section: Monocytogenes In Humans Carriagementioning

confidence: 99%

The epidemiology of human listeriosis

Swaminathan¹,

Gerner‐Smidt²

2007

Microbes and Infection

1,033

744

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“…Listeria monocytogenes is an important cause of bacteremia and meningitis in immunocompromised patients (6,12,19). Standard therapy with ampicillin or penicillin G may result in relapse (19,22,28,30) This may be related to the fact that many strains of Listeria, although inhibited by relatively low concentrations of penicillin, require much higher levels for bactericidal effect (14,20).…”

mentioning

confidence: 99%

“…Standard therapy with ampicillin or penicillin G may result in relapse (19,22,28,30) This may be related to the fact that many strains of Listeria, although inhibited by relatively low concentrations of penicillin, require much higher levels for bactericidal effect (14,20). Alternative drugs include tetracyclines, erythromycin, and chloramphenicol, which are also bacteriostatic in activity against Listeria (15,32).…”

mentioning

confidence: 99%

In vitro activities of trimethoprim and sulfamethoxazole against Listeria monocytogenes

Winslow¹,

Ga²

1982

Antimicrob Agents Chemother

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The in vitro activities of trimethoprim and sulfamethoxazole against clinical isolates of Listeria monocytogenes were examined separately and in combination with a microtiter broth dilution system. Sulfamethoxazole demonstrated variable activity and was generally bacteriostatic. Trimethoprim alone was bactericidal against 96% of isolates at c0.5 jig/ml. The bactericidal action of trimethoprim against L. monocytogenes was generally potentiated by sulfamethoxazole even when isolates were relatively resistant to sulfamethoxazole alone.

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“…Systemic listerosis is an infrequent opportunistic complication in patients undergoing treatment for hematologic malignancies (11,20) or allogeneic hematopoietic stem cell transplantation (21). Listeria monocytogenes frequently invades the central nervous system via hematogenous dissemination, leading to meningioencephalitis, cerebritis, and/or brain abscesses (10).…”

mentioning

confidence: 99%

Antimicrobial Activities against 84 Listeria monocytogenes Isolates from Patients with Systemic Listeriosis at a Comprehensive Cancer Center (1955-1997)

2003

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Listeriosis is a serious complication in patients undergoing treatment for cancer. We present antimicrobial susceptibility profiles of 84 clinical Listeria monocytogenes isolates. During 1955 to 1997, in vitro susceptibility for penicillin (97.6%), ampicillin (90.7%), erythromycin (98.8%), tetracycline (96.9%), and gentamicin (98.0%) remained unchanged. All isolates were susceptible to amikacin, ciprofloxacin, imipenem, rifampin, trimethoprim-sulfamethoxazole (TMP-SMX), and vancomycin. High prevalence of clindamycin resistance (96.2%) was unexpected. Ampicillin plus gentamicin is standard therapy for systemic listerosis, and TMP-SMX may be used for patients with beta-lactam intolerance. In vitro susceptibility profiles for carbapenem and fluoronated quinolone are promising, although clinical validation is critically needed before routine use is advocated, especially for listeric patients with severe cellular immune defects.

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Listeriosis Complicating Malignant Disease

Cited by 170 publications

References 62 publications

The epidemiology of human listeriosis

The epidemiology of human listeriosis

In vitro activities of trimethoprim and sulfamethoxazole against Listeria monocytogenes

Antimicrobial Activities against 84 Listeria monocytogenes Isolates from Patients with Systemic Listeriosis at a Comprehensive Cancer Center (1955-1997)

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