Lithium alters measures of auditory gating in two strains of mice

O’Neill, Heidi C.; Schmitt, Mischel P; Stevens, Karen E.

doi:10.1016/s0006-3223(03)00184-7

Cited by 17 publications

(13 citation statements)

References 41 publications

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“…Lithium appears to block deficits induced on prepulse inhibition by apomorphine (Umeda et al 2006) or by D-amphetamine (Ong et al 2005), but not by ketamine (Ong et al 2005). In another study, chronic lithium promoted inhibition in one strain of mice but compromised it in another (O'Neill et al 2003).…”

Section: Animal Studiesmentioning

confidence: 87%

Lithium and cognitive enhancement: leave it or take it?

et al. 2008

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Section: Animal Studiesmentioning

confidence: 87%

Lithium and cognitive enhancement: leave it or take it?

et al. 2008

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“…Comparing strains is also useful to help elucidate the molecular, cellular, and in particular genetic underpinnings that underlie response to pharmacological agents. Such comparisons been successfully used to assess the responses to various antidepressant treatments (Bai et al 2001; Can et al 2011; Cervo et al 2005; Crowley et al 2005; David et al 2003; Dubocovich et al 1990; Dulawa et al 2004; Liu and Gershenfeld 2001; Lucki et al 2001; Nomura et al 1991; Porsolt et al 1978; Ripoll et al 2003; van der Heyden et al 1987), as well as the antimanic-like effects of lithium (Gould et al 2007; Gould et al 2001; Hamburger-Bar et al 1986), and effects of lithium on pre-pulse inhibition (O'Neill et al 2003; Ong et al 2005) in the past. However, identification of inbred strains that differ in terms of the behavioral effects of a particular drug treatment is only the first step toward elucidating underlying genetic mechanisms.…”

Section: Discussionmentioning

confidence: 99%

Differential antidepressant-like response to lithium treatment between mouse strains: effects of sex, maternal care, and mixed genetic background

2013

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Background Lithium is a mood stabilizer with both antidepressant and antimanic properties, though its mechanism of action is unclear. Identifying the genetic factors that influence lithium's therapeutic actions will be an important step to assist in identifying such mechanisms. We previously reported that lithium treatment of male mice has antidepressant-like effects in the C57BL/6J strain but that such effects were absent in the BALB/cJ strain. Objectives To assess the roles of both genetic, and non-genetic factors such as sex and non-shared environmental factors that may mediate differential behavioral responses to lithium. Methods Mice were treated with lithium for ten days and then tested in the forced swim test followed by lithium discontinuation and retesting to assess effects of lithium withdrawal. We also assessed effects of sex and cross-fostering on lithium response between the C57BL/6J and BALB/cJ strains, and antidepressant-like effects of lithium in the hybrid CB6F1/J strain that is derived from C57BL/6J and BALB/cJ parental strains. Results Neither sex nor maternal care significantly influenced the differential antidepressant-like profile of lithium. Withdrawal from lithium treatment reversed antidepressant-like effects in the C57BL/6J strain, but had no effects in BALB/cJ mice. Lithium treatment did not result in antidepressant-like effects in the CB6F1/J strain. Conclusions Genetic factors are likely primarily responsible for differential antidepressant-like effects of lithium in the C57BL/6J and BALB/cJ strains. Future studies identifying such genetic factors may help to elucidate the neurobiological mechanisms of lithium's therapeutic actions.

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“…Our patients were medicated, and the impact of medication on PPI is controversial. Some studies suggest that medication may cause PPI deficits to normalize (for example with atypical antipsychotics in schizophrenic adults; 33, 34); however, it is unclear whether PPI normalization reflects a medication‐induced resolution of psychotic symptoms (9, 10, 35–37). Some studies have found that, when psychosis severity is controlled, the medication status of schizophrenic patients no longer affects PPI (29, 38).…”

Section: Discussionmentioning

confidence: 99%