Lithium Carbonate and Brain Function

Heninger, George R.

doi:10.1001/archpsyc.1978.01770260106013

Cited by 40 publications

(9 citation statements)

References 24 publications

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“…The clinical effect of lithium does not manifest itself until one to three weeks after the patient achieves therapeutic plasma levels (which usually occurs during the first week of lithium treatment). Heninger (1978) found no relationship between increased S E P 30 amplitude and changes in clinical state on lithium. However, since only a mean of 18 days had passed since instituting drug therapy, no definitive statements can be made.…”

Section: Psychopharmacologymentioning

confidence: 69%

ERPs and Psychopathology

Tueting

Kaskey

Buchsbaum

et al. 1984

Annals of the New York Academy of Sciences

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We have briefly covered important issues and considerations in four topic areas likely to be of use to the ERP researcher who is also interested in biological psychiatry. We cannot ignore diagnosis because of its basic role in the field of psychiatry. Although there are reliability problems, especially in the field of psychiatric diagnosis, ERPs may help in the painstaking task of validating diagnosis based on behavioral observation. In addition, the ERP researcher can use diagnosis to obtain potentially more homogeneous samples of patients so as to reduce between-subject error variance in studies. We have considered research areas like PET scan and CT scan which provide data of more anatomical precision than ERPs for deep neurological sites. While the potential may be there, it is essentially unrealized as yet. Finally, neurochemistry and psychopharmacology seem to be the areas most likely to bear fruit in the immediate future. If this potential is to be realized, it is necessary to formulate new questions and a new methodology to handle these questions. An important question, for example, is whether a biological profile is a more useful criterion than a behavioral profile for predicting response to pharmacological intervention. In biological psychiatry, this question is a human suffering issue of considerable importance.

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Section: Psychopharmacologymentioning

confidence: 69%

ERPs and Psychopathology

Tueting

Kaskey

Buchsbaum

et al. 1984

Annals of the New York Academy of Sciences

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“…Ein konsistentes Ergebnis stellt die unter Lithium-Therapie bei Patienten mit affektiven Psychosen gefunde-ne Amp/itudenzunahme früher Komponenten (Latenzbereich 15-50 ms) der SEP (Shagass et al 1973, Heninger 1978, Shagass et al 1982, Straumanis et al 1981 und AEP (Heninger 1978, Shagass et al 1982, Sma// et al 1971, Straumanis et al 1981 dar. Diese Veränderungen können nicht als Normalisierung interpretiert werden.…”

Section: ) Patientenunclassified

“…Die Amplitudenzunahme der P30-Komponente der SEP ist zudem ein weitgehend Lithium-spezifischer Effekt, da nach Neuroleptika oder Antidepressiva Amplitudenabnahmen dieser Komponente beschrieben wurden. Dieser Effekt ist unabhängig von der Psychopathologie, da er sowohl bei manischen Patienten als auch depressiven Patienten gefunden wurde und unabhängig vom therapeutischen Effekt (Straumanis et al 1981, Heninger 1978, Shagass et al 1973. Von Straumanis et al (1981) wird die Vermutung geäußert, daß diese Amplitudenzunahme der P30-Komponente der SEP einen pharmakologischen Effekt des Lithiums widerspiegelt, der nicht mit psychologischen Effekten oder dem Wirkmechanismus des Lithiums in Beziehung steht.…”

Section: ) Patientenunclassified

“…Bezüglich späterer Komponenten der SEP und AEP wurden teils ebenfalls Amplitudenzunahmen (Heninger 1978, Shagass et al 1982, Small et al 1971, Straumanis et al 1981, teils keine Amplitudenveränderungen (Buchsbaum et al 1979), teils Amplitudenabnahmen (Shagass et al 1982, Straumanis et al 1981 Von anderen Autoren wurden keine Amplitudeneffekte einer Lithium-Therapie auf die Amplituden der VEP beobachtet (Buchsbaum et al 1977, Greenhill et al 1973, Heninger 1978. Kaskeyet al (1980) untersuchten im Rahmen einer CPT späte Komponenten der VEP bei 15 akut manischen Patienten und fanden bei leichter Aufgabenanforderung keine Amplitudenveränderungen nach einer mehrwöchigen Lithium-Medikation (Lithium-Plasmaspiegel 0,45-1,6 mmol/I).…”

Section: ) Patientenunclassified

“…Dies wurde als Ausdruck einer Verbesserung der selektiven Aufmerksamkeit interpretiert. Heninger (1978) stellte unter Lithium-Therapie (Dauer 9-62 Tage, Lithium-Plasmaspiegel 0,7 -1,8 mmol/I) eine Latenzzunahme der NI-Komponente der SEP und AEP fest. Für spätere Komponenten der AEP (P2-und P3-Komponente) wurden Latenzabnahmen beschrieben (Shagass et al 1982, Straumanis et al 1981.…”

Section: ) Patientenunclassified

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Psychopharmaka und kortikale evozierte Potentiale

Hegerl¹

1989

Fortschr Neurol Psychiatr

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Evoked potentials (EP) are an important research instrument in psychopharmacology. They allow to investigate central nervous processes in a time range of milliseconds. Furthermore, they are useful as a link between the basal biochemical or neuroendocrinological and the psychological levels of description. The literature concerning the relationship between EP and the therapeutically important classes of psychoactive drugs (stimulants, neuroleptics, antidepressants, minor tranquilizers/sedatives, lithium salts, carbamazepine) was reviewed. The following two questions were treated separately: 1. What are the effects of psychoactive drugs on EP in healthy subjects and in patients? 2. Are EP suitable as predictors of the clinical response to psychopharmacological treatment? It was found that most effects of psychoactive drugs on the EP are not specific for one class of agents. Furthermore these effects depend on factors concerning the subject (e.g. age, gender, diagnosis, symptomatology, personality, initial value of the EP-variable), the treatment (e.g. dosage, duration), or the context and procedure of the EP recording. Therefore, the importance of evoked potentials for the classification of new psychoactive drugs has been limited until now. However, the EP research has stimulated the development of mostly psychological concepts about the way of action of some psychoactive drugs. The use EP as predictors of the response to psychopharmacological treatment seems to be promising. There are consistent findings concerning the prediction of the clinical response to stimulants and lithium salts.

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