Litseaglutinan A and Lignans from <i>Litsea glutinosa</i>

Pan, Jianyu; Zhang, Si; Wu, Jun; Li, Qingxin; Xiao, Zhihui

doi:10.1002/hlca.200900328

Cited by 12 publications

(5 citation statements)

References 14 publications

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“…There are several reports on lignans neolignans isolated from the Beilschmiedia species, such as B. tsangii, 9 B. volckii, 21 and B. kunstleri. 22 They are also reported to occur in other genus from Lauraceae family such as Endiandra, 23 Litsea, 24 Lindera, 25 Cinnamomum, 26 and Ocotea species.…”

Section: β-Sitosterol (8)mentioning

confidence: 97%

Anticholinesterase and Anti-inflammatory Constituents fromBeilschmiedia pulverulentaKosterm

et al. 2016

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− Phytochemical investigation from the stem bark of Beilschmiedia pulverulenta resulted in the isolation of five lignans, (+)-yangambin (1), (+)-sesartemin (2), (+)-excelsin (3), (+)-sesamin (4), and (+)-syringaresinol (5), together with lupeol (6), lupenone (7), β-sitosterol (8), and β-sitostenone (9). Their structures were established by the analysis of their spectroscopic (1D and 2D NMR) and spectrometric (MS) data, as well as by comparison with those reported in the literature. The isolated lignans were tested for their anticholinesterase (AChE: acetylcholine esterase and BChE: butyryl cholineesterase) and anti-inflammatory (COX-2: cyclooxygenase-2 and LOX: lipoxygenase) activities. All the isolated lignans (1 -5) exhibited significant inhibition activities in AChE/BChE and COX-2/LOX assays with IC 50 values ranging from 168.8 -504.2 µM and 21.0 -59.4 µM, respectively.

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Section: β-Sitosterol (8)mentioning

confidence: 97%

Anticholinesterase and Anti-inflammatory Constituents fromBeilschmiedia pulverulentaKosterm

et al. 2016

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“…From this group, some has been identified in another species from the Annonaceae family, like the glycosidic derivative cleistrioside 5, found in Cleistopholis patens , or some lignan derivatives [ 7 ]. Others, have only been found in different vegetal compositions, such as litsaglutinan A, a phytohormone derived from abscisic acid, involved in the regulation of seed development [ 8 , 9 ]; different glycosylated flavonoids, such as isomucronulatol [ 10 ]; several glycosidic phenylethanoids, such as osmanthuside B and (iso)verbascoside, and the phenylpropanoid magnolenin C, among others [ 11 , 12 , 13 , 14 , 15 , 16 , 17 ].…”

Section: Resultsmentioning

confidence: 99%

Determination of the Bioactive Effect of Custard Apple By-Products by In Vitro Assays

Rojas-García

Rodríguez

Cádiz-Gurrea

et al. 2022

IJMS

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Annona cherimola fruit, known as cherimoya or custard apple, is an exotic fruit from South America but is strongly produced in Andalusia, Spain. Its by-products (seeds and peel) are recognised as important sources of antioxidants, including phenolic acids, flavonoids and procyanidins. Therefore, the aim of this study was to carry out the characterization of its phenolic composition and to in vitro evaluate the bioactivity of custard apple seed and peel. Therefore, high performance liquid chromatography coupled to mass spectrometry (HPLC-ESI-qTOF-MS) was performed in order to tentatively identify their phenolic composition. In the end, 19 compounds were identified and quantified, some of them for the first time in the custard apple matrix. Then, seed and peel total phenolic content, as well as antioxidant properties, radical scavenging capacity (O2, NO, HOCl) and inhibition of enzymes involved in different pathologies (hyaluronidase, elastase, collagenase, tyrosinase, acetylcholinesterase and xanthine oxidase), were evaluated. Although both extracts showed almost similar antioxidant capacities, custard apple seed stood out slightly more than peel (171 ± 2 vs. 130.0 ± 0.4 μmol TE/g DE, resp.), especially as ·NO scavenger (IC50 1.5 ± 0.2 vs. 11.8 ± 0.3 mg/L, resp.) and hyaluronidase inhibitor (IC50 170 ± 10 vs. 460 ± 20mg/L, resp.). Finally, the application of extracts on a real human model of platelet aggregation was performed, reporting antiaggregatory effects in agonist-promoted platelet thrombus formation. All these results show that custard apple by-products are stated as interesting sources of bioactive compounds with multiple industrial applications for the development of high-added-value products, such as functional foods, nutraceuticals and cosmeceuticals, promoting the circular bioeconomy of these by-products.

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“…Tannin, β-sitosterol and actinodaphnine are reported to be the common constituents of the species. Major clusters of antimicrobial compounds including alkaloids (Feng et al, 2009), butanoides (Chang et al, 2008), flavonoids (Wang and Liu, 2010), lignans (Pan et al, 2010), sesquiterpenes (Agarwal et al, 2011), and essential oils (Chowdhary et al, 2008) have been discovered in Litsea spp. These compounds have shown significant biological activities including anti-inflammatory (Devi and Meera, 2010), antitumor (Cheng et al, 2010), anticancer (Hosseinzadeh et al, 2013), antioxidant (Jia et al, 2013), antidepressant (Guzman and Navarrete, 2009) and antiphyperalgesic (Silva et al, 2012) properties.…”

Section: Resultsmentioning

confidence: 99%

Litsea glutinosa (Lauraceae): Evaluation of its Foliar Phytochemical Constituents for Antimicrobial Activity

Lagudu

Owk

2018

Not Sci Biol

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The phytochemical investigation of the leaves of Litsea glutinosa revealed the presence of secondary metabolites like alkaloids, anthraquinones, cardiac glycosides, flavonoids, glycosides, phenols, saponins, steroids, tannins, terpenoids, volatile compounds, amino acids and carbohiydrates. The antimicrobial activity and minimum inhibition concentration values were determined for these phytochemical constituents as crude extracts using the agar well diffusion and two-fold serial dilution methods. The results indicated that Bacillus subtilis was the most susceptible bacterium with high inhibition zones for the methanol and chloroform extracts of 31 mm and 26 mm, respectively. The MIC values indicated that extracts possess good antimicrobial activity with significant MIC value against Enterococcus faecalis, Pseudomonas aeruginosa and Staphylococcus pneumoniae at 31.2 µg/ml concentrations. The extracts showed marked antimicrobial activity against both bacteria and fungi. Among the bacterial strains, gram-positive bacteria were more susceptible than the gram-negative. All the 13 microorganisms tested showed dose dependent susceptibility towards the phytochemicals present in the foliar extracts. The study suggests that Litsea glutinosa leaves possess potent antimicrobial activity and can be a good source for the development of new antibiotics.

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Litseaglutinan A and Lignans from Litsea glutinosa

Cited by 12 publications

References 14 publications

Anticholinesterase and Anti-inflammatory Constituents fromBeilschmiedia pulverulentaKosterm

Anticholinesterase and Anti-inflammatory Constituents fromBeilschmiedia pulverulentaKosterm

Determination of the Bioactive Effect of Custard Apple By-Products by In Vitro Assays

Litsea glutinosa (Lauraceae): Evaluation of its Foliar Phytochemical Constituents for Antimicrobial Activity

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