Livedo racemosa mit Ulzerationen

Abstract

A 43 year old woman suffered from an intermittent painful livedo racemosa at the back since her childhood. Her clinical course was complicated by ulcerations. In careful clinical investigations no signs of an underlying disease could be found, in particular a Sneddon syndrome could be excluded. By means of both conservative and surgical treatments, initial healing of the ulcerations was achieved but relapses occurred. Cyclic infusions of iloprost achieved long-term clearing of the ulcerations and disappearance of the pain. To the best of our knowledge the effectiveness of this treatment has not been described for this disease in the literature.

Treatment of livedoid vasculopathy with alprostadil (PGE‐1): case report and review of published literature

“…In the past, 11 patients with ulcerating livedoid vasculopathy were treated with prostanoids, four with PGE-1, 2-5 four with beraprost 6 and three with iloprost have been reported on in the published literature [7][8][9] (Table 1). In a review article, Wohlrab et al have given practical suggestions for treatment with PGE-1.…”

“…6 Prostacyclin 2 ng ⁄ kg ⁄ min was given for 10-14 days and then by ongoing intermittent therapy 7,8 or also in a dosage of 2 · 50 lg for 6 h (=0.04 lg ⁄ kg ⁄ min) for 7 days in addition to anticoagulation therapy with a dramatic effect. 9 By repeating the iloprost infusions once or twice a year for a period of 5 days recurrence of ulcers was inhibited.…”