Liver abscess of children in Côte-d’Ivoire

Kouassi-Dria, Amenankan S.; Moh, N.; Aké, Yapi L.; Midekor-Gonebo, K.; Keita, Balla; Bonny-Obro, Rebecca; Aguehounde, C.

doi:10.1097/01.xps.0000521800.43379.30

Cited by 8 publications

(13 citation statements)

References 16 publications

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“…Age at diagnosis reported in most studies was close, including 10 years in a UK study and 8 years in an Iranian study (14,16). A few studies conducted in the developing world disclosed a trend of a younger age at diagnosis, such as 6.3 years in west India, 8.1 years in Brazil, and 5.4 years in the Côte d'Ivoire (3,15,17). Earlier and prolonged exposures to a pathogenic source with limited hygiene in these tropical or developing areas were proposed as reasons contributing to this trend of younger occurrence (3,14).…”

Section: Discussionmentioning

confidence: 89%

“…Similar to previous studies, a declining trend of incidence was observed among Taiwanese children, even though those previous studies were not population-based. Incidence varies among studies from different countries, reflecting a possible association with sanitation, healthcare access, and nutritional condition (2,3,14,15).…”

Section: Discussionmentioning

confidence: 99%

“…For example, previous studies disclosed the dominance of Klebsiella pneumoniae as the causative pathogen in Taiwanese adults and children (2,9,10), while Staphylococcus aureus and Entamoeba histolytica are more prevalent in other countries. Mean age at diagnosis for Taiwanese children is relatively older than that in other series (3,(9)(10)(11). Overall, the treatment outcome has been improving gradually with higher clinical suspicion and rigorous treatment, although we still possess no consensual algorithm.…”

Section: Introductionmentioning

confidence: 89%

“…Liver abscess is an important yet relatively uncommon disease in children, with varied incidence and prevalence worldwide (1). Liver abscess is uncommon in developed countries but remains a significant infectious issue for children residing in developing countries (2)(3)(4). The incidence rates reported in previous studies ranged from 25 per 100,000 pediatric admissions in the USA, 79 per 100,000 pediatric admissions in India, and up to 400 per 100,000 pediatric admissions in Cote d'Ivoire (3,5,6).…”

Section: Introductionmentioning

confidence: 99%

“…Liver abscess is uncommon in developed countries but remains a significant infectious issue for children residing in developing countries (2)(3)(4). The incidence rates reported in previous studies ranged from 25 per 100,000 pediatric admissions in the USA, 79 per 100,000 pediatric admissions in India, and up to 400 per 100,000 pediatric admissions in Cote d'Ivoire (3,5,6). Although a nationwide all-age analysis for pyogenic liver abscess in Taiwan revealed an increasing annual incidence from 1996 (11.15 per 100,000) to 2004 (17.59 per 100,000) (7), two pediatric single institution-based studies disclosed a decline from 20 per 100,000 pediatric admissions in 1979-1992 to 8.3 per 100,000 pediatric admissions in 1986-2001 (8,9).…”

Section: Introductionmentioning

confidence: 99%

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Pediatric Liver Abscess: Trends in the Incidence, Etiology, and Outcomes Based on 20-Years of Experience at a Tertiary Center

et al. 2020

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Background: Liver abscess is an important but relatively rare disease in children. This study investigated the clinical characteristics of eligible patients at a referral tertiary center over the past two decades. Method: A 20-year retrospective study (January 2000-December 2019) enrolled 38 children diagnosed with liver abscess. Demographic data; clinical features; laboratory, imaging, and microbiological findings; management strategy; and outcomes were reviewed from the patients' medical records. Results: Thirty-eight cases of pyogenic liver abscess were identified without a culture-proven amebic or fungal abscess. The mean age of diagnosis was 9.6 ± 6.2 years, and the male-to-female ratio was 1.92: 1. Hemato-oncological (28.9%) and predisposing hepatobiliary diseases (23.7%) were the two most common predisposing factors. Fever (94.7%) was the most common presentation followed by right upper quadrant abdominal pain (42.1%) and pleural effusion (34.2%). Among the laboratory parameters, leukocytosis was common (70.3%), and all patients had elevated serum C-reactive protein levels. Increased serum levels of alanine aminotransferase, aspartate aminotransferase, direct bilirubin, and total bilirubin were found in 40.5, 48.6, 23.1, and 42.9% of the cases, respectively. The most common pathogen in blood and pus cultures was Klebsiella pneumoniae. The mean durations of intravenous antibiotic and total antibiotic use were 29.0 ± 15.7 and 45.1 ± 22.1 days, respectively. Twelve patients (31.6%) were treated with antibiotics alone, while percutaneous needle aspiration, percutaneous pigtail drainage, and surgical intervention were performed in 12 (31.6%), 10 (26.3%), and 5 (13.2%) patients, respectively. No mortality was documented in this series. Conclusion: The present study reflects a relatively declining incidence of liver abscess compared with prior studies in Taiwan. K. pneumoniae remains the most prevalent pathogen in both blood and abscess cultures in Taiwan. Proper antimicrobial therapy with timely drainage generally yielded an adequate treatment response without any mortality.

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