Liver and Kidney Function and Histology in Rats Exposed to Cadmium and Ethanol

Brzóska, Małgorzata M.; Moniuszko-Jakoniuk, J; Piłat-Marcinkiewicz, B; Sawicki, B

doi:10.1093/alcalc/agg006

Cited by 138 publications

(105 citation statements)

References 17 publications

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“…Some clinical and experimental studies have also been focused on the effects of ethanol feeding on renal function, gross and microscopic morphology of the kidney. [6][7][8] While acute alcohol consumption has a nephrotoxic effect on the kidney, alternatively, chronic use in humans may result in alcohol-induced hypertension, indirectly increasing the risk of chronic kidney disease. 9,10 Oxidative stress is an imbalance favoring prooxidants and/or disfavoring antioxidants, potentially leading to tissue damage.…”

Section: Introductionmentioning

confidence: 99%

Melatonin and Vitamin C Ameliorate Alcohol-Induced Oxidative Stress and eNOS Expression in Rat Kidney

et al. 2012

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Objectives: The aim of this study was to investigate the preventive effects of melatonin and vitamin C as antioxidants on renal injury in chronic alcohol consumption. Materials and methods: A total of 24 adult male Wistar rats weighing 200-250 g were used in the study. Rats were divided into four equal groups. Group I (control): rats were not fed on alcohol; Group II: rats were fed on alcohol; Group III: rats were fed on alcohol and 40 mg/kg vitamin C; and Group IV: rats were fed on alcohol and 4 mg/kg melatonin. Results: Light microscopic examination revealed atrophic renal corpuscles, dilatation and congestion of the peritubular vessels, and renal corpuscles with obscure Bowman's space and a few foamy-appearing tubules due to alcohol consumption were observed. Expression of endothelial nitric oxide synthase (eNOS) was localized to glomerulus, distal, and collector tubules. eNOS staining decreased in alcohol treatment group and melatonin and vitamin C encore increased expression pattern of eNOS. Alcohol consumption increased malondialdehyde (MDA) level and superoxide dismutase (SOD) and catalase (CAT) activities significantly in the alcohol consumption groups compared with that in the control group, while in melatonin give group just MDA level was decreased statistically significant and SOD and CAT activities were also decreased numerically compared with the alcohol consumption groups. Conclusions: These results indicated that chronic alcohol consumption caused renal damage by increased lipid peroxidation and melatonin and vitamin C administration produced in some degree protection against alcohol-induced damage.

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Section: Introductionmentioning

confidence: 99%

Melatonin and Vitamin C Ameliorate Alcohol-Induced Oxidative Stress and eNOS Expression in Rat Kidney

et al. 2012

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“…A number of authors (Rebrov & Gromova, 2008) point out that alcohol increases the loss of magnesium through the kidneys and alcoholics are often found deficient in this element. The effect of ethanol on the increase in nephrotoxicity of cadmium in rats was proposed in the work (Brzoska, Moniuszko-Jakoniuk, Piłat-Marcinkiewicz, & Sawicki, 2003). Clinical studies confirm the toxic effects of cadmium on renal function (de Burbure, C. et al, 2006).…”

Section: Resultsmentioning

confidence: 96%

“…Cadmium metabolism and toxicity can change under the influence of different factors. (Brzoska, Moniuszko-Jakoniuk, Piłat-Marcinkiewicz, & Sawicki, 2003).…”

Section: Introductionmentioning

confidence: 99%

Elemental Composition and Morphological Characteristics of Kidney under the Influence of Toxicants

Kiyaeva¹,

Нотова²,

Алиджанова³

et al. 2015

MAS

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Morphological changes and element status in laboratory animals under the influence of ethanol and cadmium were studied. Male Wistar rats were under investigation. Experimental animals received standard diet and in addition 15% ethanol solution and cadmium sulfate orally. Histologic and morphometric studies were done. Routine Mayer's hematoxylin and eosin stain for renal histological sections was used. Ocular micrometer МОВ-1-15х1500 and software "Test Morpho 4.0" were used for investigation of histological and cytological structures of kidneys. Digital images were produced by microscope "Micros" (Austria).The methods of inductively coupled plasma spectroscopy and atomic emission spectroscopy (Optima 2000 DV and ELAN 9000, PerkinElmer, USA) were used for the elemental study of samples.The combined effect of ethanol and cadmium sulfate caused renal damage which was confirmed morphologically. It was found that 65% nephrons were exposed to destruction with microinfarctions. Volume of 80% renal corpuscles was reduced, but volume of nephrocytes was extended at all levels of nephron. Cavities of the renal tubule were extended in the area of Henle's loop. In addition to kidney damage the concentrations of Mg, P, As, Fe, Cu, Si, Zn were decreased and Cd concentration was increased in the blood of laboratory animals, who were exposed to ethanol and cadmium. The concentration of cadmium was 86 times (p ≤ 0,001) higher and the concentration of lead was 25 times (p ≤ 0.05) higher in the hair of animals from the experimental group than in the hair of animals from the control group.

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“…Subsequently, these reductions can cause tissue degradations [38]. Liver and kidney are important organs of storage, detoxification, metabolism, and excretion of many metabolites, so they are particularly vulnerable to oxidative damage [43]. Liver is important organ that its main function is maintaining and control blood glucose with glycogenesis and glycogenolysis.…”

Section: Discussionmentioning

confidence: 99%

Effect of Pomegranate on Histopathology of Liver and Kidney on Generated Oxidative Stress Diabetic Induced Rats

Rahmat¹

2015

J Cytol Histol

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Oxidative stress has been recommended as a contributory factor in complication and progression of diabetes. The aim of the study was to evaluate the effects of pomegranate on body weight and histopathology of the steptozotocin-nicotiamide (STZ-NA) generated oxidative stress induced diabetic rats. Thirty-two male SpragueDawley rats were randomly divided into non-diabetic, diabetic untreated and diabetic treated with pomegranate and Glibenclamide. Experimental diabetes was induced by a single intraperitoneal (i.p) administration of STZ 60 mg/kg body weight (b.w), 15 minutes after the i.p injection of NA (120 mg/kg b.w). Histopathological analyses were conducted on the liver and kidney tissues. While the body weight significantly decreased in the diabetic control group, however it was a significant increase in the diabetic treated group (P<0.05). Destruction of the liver architecture of the hepatocytes in the diabetic group showed the signs of necrosis, degeneration, dilatation, and inflammation in the central vein and blood vessels. In the kidney, shrinkage and lesion in Bowman's capsule were observed. Pomegranate acted as an antioxidant thereby preventing oxidative damage in the diabetic liver and kidney.

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Liver and Kidney Function and Histology in Rats Exposed to Cadmium and Ethanol

Cited by 138 publications

References 17 publications

Melatonin and Vitamin C Ameliorate Alcohol-Induced Oxidative Stress and eNOS Expression in Rat Kidney

Melatonin and Vitamin C Ameliorate Alcohol-Induced Oxidative Stress and eNOS Expression in Rat Kidney

Elemental Composition and Morphological Characteristics of Kidney under the Influence of Toxicants

Effect of Pomegranate on Histopathology of Liver and Kidney on Generated Oxidative Stress Diabetic Induced Rats

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