Liver autopsy study – incidental pathological findings

Behera, Aniruddha; Sahu, Alaka; Nayak, Salil Kumar; Agrawal, Kailash Chandra

doi:10.17511/jopm.2017.i04.05

Cited by 5 publications

(5 citation statements)

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“…Most of the studies had a much higher incidence of unremarkable histology than our study, however, it compares well with that of Porwal V et al 8 Full blown cirrhosis was seen in 8.2% of cases, similar to the findings of Sameer MA et al, Bhagat R et al and Behera A et al 1,2,10 However early changes of cirrhosis were seen in 22 cases. Some of these had associated fatty change, necrosis and Mallory-Denk bodies.…”

Section: Discussionsupporting

confidence: 90%

Histopathological spectrum of liver lesions at autopsy: A cross sectional study

Sakhare¹,

Hingway

2022

PJMS

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Liver is the principal site of many metabolic activities and is vulnerable to many metabolic, toxic, microbial and circulatory insults. It is frequently involved in metastatic spread of malignancies from all parts of body. This study aimed to analyze histopathological spectrum of liver diseases in autopsy cases, and correlate with the clinical findings wherever available. It was an observational study conducted over a period of 2 years on 283 autopsy cases in department of Pathology of a tertiary care teaching institute in central India. Liver specimens were included in study irrespective of age, sex and cause of death. After fixation in 10% formalin the sections from representative area were submitted for processing, Hematoxylin and Eosin-stained sections were subjected for microscopic examination. Total 283 liver autopsy cases studied showed predominance of male (68.65%). Maximum cases were in the age group of 21 to 30 years (20.14%) followed by 31 to 40 years (18.28%). Fatty change was evident in a majority (32.08%) of the cases while a remarkable (26.49%) number of cases showed changes of congestion on histological examination. Massive hepatocellular necrosis and midzonal necrosis were seen in 2 cases each. Tubercular granulomas and metastasis of adenocarcinoma were seen in 3 cases each. Histological analysis of liver is important learning objective for pathologists to study silent diseases of liver which are incidentally seen in histopathology.

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Section: Discussionsupporting

confidence: 90%

Histopathological spectrum of liver lesions at autopsy: A cross sectional study

Sakhare¹,

Hingway

2022

PJMS

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“…Hepatitis constituted 12.5% of total cases our study. This is in accordance to the studies conducted by Behera et al5 (12.5%), Bhagat et al 1 (18.3%) and Selvi et al 8 (13.9%). Cirrhosis contributed only 2.5% of the liver diseases in the present study.…”

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confidence: 93%

Liver Pathology in Autopsy Cases: A Retrospective Study in A Tertiary Care Center

2020

IJFMT

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Background: Liver is the site of many diseases, many become symptomatic while few are diagnosed only on autopsy. The cause of chronic liver disease varies in different geographic areas and influenced by socioeconomic status, diet, life style and regional diseases.Method: This retrospective study was carried out in a tertiary care hospital in the department of pathology over a period of one year. A total of 40 cases of liver specimens, received as part of liver, constituted the material for the study. All were autopsy cases and the organs were received in 10% formalin. Routine grossing and staining with H&E stain were performed. Slides were analysed and the findings were noted in percentages.Results: A total of 40 specimens were studied. Age ranges from new born to 70 years, with 92.5 % male cases. 32.5% of cases were autolysed. 25% were showing chronic venous congestion followed by fatty change (22.5%), hepatitis (12.5%). 2.5% each of cirrhosis, steatohepatitis and normal liver. Conclusion:1. Autopsy has an important role in identifying the cause of death.2. To overcome the autolysis of the specimen, the medical practitioner performing the autopsies should be trained about how to carry post mortem and to preserve the viscera for histopathological examination so that cause of death could be noted.

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“…Hepatitis of various morphology were acute hepatitis 3.5%(23) and chronic hepatitis 0.3%(2), tuberculosis/ granulomatous hepatitis 0.6%(4) followed by cirrhosis in 2.2%(14) of cases. Neoplastic lesions were seen in 1%(6) cases of which primary malignancy was seen only as one case of hepatocellular carcinoma (1). the rest of neoplastic lesions comprised of secondaries from haematological malignancies were 5 case.…”

Section: Resultsmentioning

confidence: 99%

“…Liver is the site of many diseases many of which become symptomatic while some are diagnosed only on autopsy examination. 1 Liver is vulnerable to a variety of metabolic, toxic, microbial and circulatory insults. 2 Sometimes the disease is primary while in others the hepatic involvement is secondary to cardiac decompensation , alcoholism or extrahepatic infections .most of the chronic liver diseases even in advanced stages may cause no prominent clinical signs and symptoms.…”

Section: Introductionmentioning

confidence: 99%

Comparative study of pathological lesions of liver in autopsy cases

Simon¹,

Dantkale²,

Shinde³

2020

Int J Res Med Sci

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Background: Liver is a site for plethora of diseases among which many become symptomatic while others usually either go undiagnosed or are concealed by other prominent diseases. As said about liver to be the custodian of milieu interior most of the silent liver diseases are diagnosed only on autopsy examination. Aims and objectives was to study various pathological lesions of liver in medicolegal and clinical autopsy cases and to corelate liver diseases with age and sex. Retrospective cross-sectional observational study of 649 medicolegal and clinical autopsies conducted within 2 years of duration (January 2017 to December 2018).Methods: Out of all 649 autopsies conducted in our hospital all liver specimens along with other organs viscera were collected and formalin fixed. After gross examination sections from the liver were submitted for tissue processing and then stained with haematoxylin and eosin stain.Results: The most common pathology found in our study was fatty change (11.1%) followed by venous congestion (4.3%), hepatitis (3.5%), cirrhosis (2.2%), tuberculosis/ granulomatous hepatitis (0.6%), chronic hepatitis (0.3%), malignancy (1%), miscellaneous (2%) and normal (72.4%). Maximum cases were in 21-30 years of age group with male preponderance.Conclusions: Autopsy examination of liver is an effective tool to identify silent liver diseases. Use of autopsy findings along with other investigative techniques.

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Liver autopsy study – incidental pathological findings

Cited by 5 publications

References 1 publication

Histopathological spectrum of liver lesions at autopsy: A cross sectional study

Histopathological spectrum of liver lesions at autopsy: A cross sectional study

Liver Pathology in Autopsy Cases: A Retrospective Study in A Tertiary Care Center

Comparative study of pathological lesions of liver in autopsy cases

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