Liver cirrhosis as a real risk factor for necrotising fasciitis: a three-year population-based follow-up study

Hung, T Y; Tsai, Chang‐Youh; Tseng, C. F.; Hsieh, Yu–Hsi

doi:10.11622/smedj.2014090

Cited by 17 publications

(5 citation statements)

References 38 publications

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“…Cirrhosis-associated immune dysfunction refers to immunodeficiency and systemic inflammation that occur during cirrhosis [44]. Cirrhosis can impair the intestinal–portal route barrier, thus facilitating bacterial entry into the systemic circulation and increasing the susceptibility to various infectious diseases, such as respiratory infections, spontaneous bacterial peritonitis, or urinary tract infections [45,46]. The concomitant presence of impaired phagocytosis, poor opsonization capacity, low complement levels, and impaired reticuloendothelial system in patients with cirrhosis increases their susceptibility to bacteremia [42,45,47].…”

Section: Discussionmentioning

confidence: 99%

The Association Between Decompensated Liver Cirrhosis and Deep Neck Infection: Real-World Evidence

Tsai

Chang

Chen

et al. 2019

IJERPH

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Background: Deep neck infection (DNI) can progress to become a life-threatening complication. Liver cirrhosis, which is related to poor immune conditions, is a likely risk factor for DNI. This study investigated the risk and mortality of DNI in patients with decompensated liver cirrhosis (DLC). Methods: We performed a nationwide cohort study using the National Health Insurance Research Database (NHIRD) in Taiwan. We included a total of 33,175 patients with DLC between 2000 and 2013, from the Catastrophic Illness Patient Database, a subsection of the NHIRD, along with 33,175 patients without cirrhosis who were matched in a 1:1 proportion for age, sex, and socioeconomic status. The occurrence of DNI was the primary study outcome. The risk, treatment, and mortalities of DNI were evaluated in the study and comparison cohorts. Results: DLC Patients had a significantly higher incidence of DNI than noncirrhotic patients (p < 0.001). The adjusted Cox proportional hazard regression showed that DLC was associated with a significantly higher risk of DNI (adjusted hazard ratio, 4.11; 95% confidence interval, 3.16–5.35, p < 0.001). The mortality rate in cirrhotic patients with DNI was not significantly higher than that in noncirrhotic patients with DNI (11.6% vs. 9.8%; p = 0.651). Conclusions: This study is the first to investigate the correlation between DLC and DNI. The study findings strongly indicate that DLC is an independent risk factor for DNI. Cirrhotic patients with DNI do not have a significantly poorer survival rate than noncirrhotic patients with DNI. Therefore, physicians should be alert to potential DNI occurrence in DLC patients. Besides this, intensive care and appropriate surgical drainage can yield similar survival outcomes in DLC-DNI and noncirrhosis-DNI patients.

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Section: Discussionmentioning

confidence: 99%

The Association Between Decompensated Liver Cirrhosis and Deep Neck Infection: Real-World Evidence

Tsai

Chang

Chen

et al. 2019

IJERPH

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“…Various types of chronic injury may lead to liver fi brosis, such as auto-immune destruction of hepatocytes, metabolic diseases, alcohol abuse, congenital abnormalities, drugs and viral hepatitis [13,14]. Since alcoholism is an important deathleading factor among patients with cirrhosis and liver cancers, the association between alcohol and mortality of patients with hepatopathy is obvious [15,16]. In addition, alcohol intake can lead to ascites formation and venous bleeding, according to Peter Jepsen, which further intensify the related complications of liver fi brosis [17].…”

Section: Occurrence Of Hepatic Fi Brosis and Cirrhosismentioning

confidence: 99%

Occurrence, diagnosis and management of hepatic fibrosis and cirrhosis: An updated literature review

Qiao¹

2019

Arch Hepat Res

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Background: Hepatic fi brosis and cirrhosis, characterized with signifi cant morbidity and mortality, have always been worldwide health care problems. Objective: This manuscript is aimed at providing a research progress overview of hepatic fi brosis and cirrhosis. Method: Online search for articles published in years from 2009 to 2019 with "hepatic fi brosis", "cirrhosis", "therapy", "liver disease" and "hepatitis" as keywords. The adopted database involves PubMed, MIDLINE, Google Scholar, CNKI and EMBASE. Result: This review summarizes the latest fi ndings about pathogenesis, diagnosis and therapies of hepatic fi brosis and cirrhosis, and describes their application prospect and future research directions, providing references to some extent for fellow academics.

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“…Several reports have shown that liver cirrhosis is a common underlying disease in patients with NF. [17][18][19] Despite improved medical care, the mortality rates in patients with NF remain high, especially among patients with cirrhosis, in whom rates have been reported to be nearly ninefold when compared with that among patients with NF without cirrhosis. 17 Although the diagnosis is essentially clinical, imaging is useful to map the extent of disease to aid in surgical planning and to exclude other disease processes.…”

Section: Necrotizing Fasciitismentioning

confidence: 99%

Cirrhosis-related musculoskeletal disease: radiological review

Arora¹,

Rajesh²,

Bansal³

et al. 2016

BJR

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Musculoskeletal problems in patients with liver disease are common; however, they are not so well described in the literature. Therefore, there is a need to collate information on these disorders, as their incidence is on a constant rise and some of these pathologies can severely debilitate the patient's quality of life. These disorders are parietal wall varices with or without bleeding, spontaneous intramuscular haematoma (e.g. rectus sheath), abdominal wall hernia, anasarca, hepatic osteodystrophy, septic arthritis, osteomyelitis, necrotizing fasciitis, osseous metastases from hepatocellular carcinoma etc. While portal hypertension plays a key role in disorders, in others, dysregulation of the coagulation system or a compromised immune system are responsible. Imaging plays an essential role in the assessment of these complications and awareness of these musculoskeletal manifestations is vital for establishing a timely diagnosis and planning of appropriate therapy, as these disorders can significantly impact the morbidity and mortality and also influence candidacy for liver transplantation. We herein comprehensively appraise various musculoskeletal complications associated with chronic liver disease/liver cirrhosis especially from an imaging perspective which, to the best of our knowledge, have not been collectively described in English literature.

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Liver cirrhosis as a real risk factor for necrotising fasciitis: a three-year population-based follow-up study

Cited by 17 publications

References 38 publications

The Association Between Decompensated Liver Cirrhosis and Deep Neck Infection: Real-World Evidence

The Association Between Decompensated Liver Cirrhosis and Deep Neck Infection: Real-World Evidence

Occurrence, diagnosis and management of hepatic fibrosis and cirrhosis: An updated literature review

Cirrhosis-related musculoskeletal disease: radiological review

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