Liver Cirrhosis: Intravoxel Incoherent Motion MR Imaging—Pilot Study

Luciani, Alain; Vignaud, Alexandre; Cavet, Madeleine; Nhieu, Jeanne Tran Van; Mallat, Ariane; Ruel, L.; Laurent, Alexis; Deux, Jean-François; Brugières, Pierre; Rahmouni, Alain

doi:10.1148/radiol.2493080080

Cited by 576 publications

(639 citation statements)

References 33 publications

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“…Previously, the use of IVIM imaging was limited to neuroradiologic applications because the abdominal organs can be subject to respiratory and other motion artifacts. The advent of respiratory gating combined with parallel imaging allows IVIM MRI to be attempted in the evaluation of abdominal organs, such as liver (7)(8)(9)(10)(11)(12). Yamada et al (7) were the first to assess IVIM MRI in abdominal organs, although they used only limited number of b values (30, 300, 900, and 1,100 s/mm 2 ), and did not calculate pseudodiffusion values.…”

Section: Introduction and Basic Principles Of Intravoxel Incoherent Mmentioning

confidence: 99%

Liver intravoxel incoherent motion (IVIM) magnetic resonance imaging: a comprehensive review of published data on normal values and applications for fibrosis and tumor evaluation

Lǐ¹,

Cercueil²,

Yuan³

et al. 2017

Quant. Imaging Med. Surg.

131

210

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Section: Introduction and Basic Principles Of Intravoxel Incoherent Mmentioning

confidence: 99%

Liver intravoxel incoherent motion (IVIM) magnetic resonance imaging: a comprehensive review of published data on normal values and applications for fibrosis and tumor evaluation

Lǐ¹,

Cercueil²,

Yuan³

et al. 2017

Quant. Imaging Med. Surg.

131

210

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“…There are reports that D * and ADC values of patients with cirrhosis are significantly lower than in healthy individuals [3]. The increase in portal blood flow due to food intake is larger in healthy people, so it is expected that there will be little effect in patients with cirrhosis.…”

Section: Discussionmentioning

confidence: 97%

“…Recent advances in equipment brought the feasibility of IVIM to clinical use. Luciani et al reported that IVIM was useful for diagnosis of liver cirrhosis [3]. They clarified using IVIM that decreasing microcirculation led to the diffusion restriction in liver cirrhosis.…”

Section: Introductionmentioning

confidence: 99%

Effect of Food Intake on Intravoxel Incoherent Motion and T2* in the Healthy Liver

Shimizu¹,

Saito²,

Shirota³

et al. 2017

OMICS J Radiol

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“…Second, no pathologic evaluation was performed. Third, the ADC values were calculated by monoexponential analysis of the signal in this study, whereas bi-exponential analysis may have provided more detailed information regarding focal tissue non-invasively [26]. Fourth, recent studies have compared pretreatment of the ADC of the tumor with the tumor reduction ratio.…”

Section: Discussionmentioning

confidence: 99%

Preliminary study of apparent diffusion coefficient assessment after ion beam therapy for hepatocellular carcinoma

Kanamoto

Miyati

Terashima

et al. 2016

Radiol Phys Technol

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We evaluated the state of hepatocellular carcinoma (HCC) and the liver after ion beam therapy by analyzing the apparent diffusion coefficient (ADC). In this retrospective study, we evaluated 13 HCC lesions in 10 patients who underwent magnetic resonance imaging before and after therapy. Diffusion-weighted imaging was performed with use of b values of 0, 150, and 800 s/mm 2 . The ADC was determined for the tumor, irradiated liver, and normal liver. The maximum size of the tumor was measured, and reduction in tumor size was determined as a ratio of the maximum size of the diameter of the tumor. We compared the ADC before and after the therapy with the reduction in tumor size ratio. The reduction in tumor size ratio was compared with the ADCs of the tumors. The ADC of the tumor and the irradiated liver were significantly higher after therapy than before therapy. The ADC of the normal liver was not significantly different before and after therapy. The reduction ratio increased significantly (R = 0.73, P = 0.006) after therapy at the second follow-up when compared with after therapy at the first follow-up. No correlation was found between the reduction ratio and the ADC of the tumor in each follow-up. Inflammation of the liver occurs after treatment as a result of radiation doses from the ion beam, and the tumor reaches a state of necrosis. ADC value analysis provides a non-invasive assessment and yields focal information regarding the tumor and liver before and after ion beam therapy.

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Liver Cirrhosis: Intravoxel Incoherent Motion MR Imaging—Pilot Study

Abstract: Restricted diffusion observed in patients with cirrhosis may be related to D* variations, which reflect decreased perfusion, as well as alterations in pure molecular water diffusion in cirrhotic livers.

Cited by 576 publications

References 33 publications

Liver intravoxel incoherent motion (IVIM) magnetic resonance imaging: a comprehensive review of published data on normal values and applications for fibrosis and tumor evaluation

Liver intravoxel incoherent motion (IVIM) magnetic resonance imaging: a comprehensive review of published data on normal values and applications for fibrosis and tumor evaluation

Effect of Food Intake on Intravoxel Incoherent Motion and T2* in the Healthy Liver

Preliminary study of apparent diffusion coefficient assessment after ion beam therapy for hepatocellular carcinoma

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