Liver Disease Due to Infection and Allergy

Mackay, Ian R.

doi:10.1007/978-3-642-45483-7_2

Cited by 4 publications

(1 citation statement)

References 428 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There are several specifically hepatotropic viruses A–E, and yellow fever virus, and the liver is sometimes affected in various systemic viral diseases, including Epstein–Barr, measles, herpes simplex and cytomegalovirus 25 . However, only the hepatitis B and C viruses (HBV, HCV) result in serious chronic infections 26 .…”

Section: Pathological Responses In the Livermentioning

confidence: 99%

Hepatoimmunology: A perspective

Mackay

2002

Immunol Cell Biol

117

View full text Add to dashboard Cite

Summary Premises for the subspecialty of hepatoimmunology include the recognition that the liver is a lymphoid organ with unique immunological properties. These properties ensure efficient innate defence against intestinal microbes and toxins, confer a particular capacity for induction of tolerance, and provide for apoptotic disposal of redundant lymphocytes. Pathological responses within the liver are elicited when: (i) hepatotropic viruses (hepatitis virus B and C) escape immune elimination and reside in hepatocytes; (ii) the liver becomes the site of autoimmune responses directed against either hepatocytes (autoimmune hepatitis) or biliary ductules (primary biliary cirrhosis); or (iii) the liver in the course of disposal of drugs generates neoantigens that provoke adverse allergic responses. Recent advances in the understanding of the immunopathogenesis of these entities are reviewed.

show abstract

Section: Pathological Responses In the Livermentioning

confidence: 99%

Hepatoimmunology: A perspective

Mackay

2002

Immunol Cell Biol

117

View full text Add to dashboard Cite

show abstract

Hypersensitivity Caused by Synthetic Thyroid Hormones in a Hypothyroid Patient With Hashimoto's Thyroiditis

Shibata¹,

Hayakawa²,

Hirukawa³

et al. 1986

Arch Intern Med

View full text Add to dashboard Cite

Auto‐immune hepatitis: Lifting the seventh veil

Mackay

1988

J of Gastro and Hepatol

View full text Add to dashboard Cite

Knowledge of auto‐immune chronic active hepatitis (AI‐CAH) has developed since the 1940s. Using the analogy of the seven veils, the lifting of the first six could be represented by the finding of: hypergammaglobulinaemia; recognition of the clinical syndrome; the hepatic histopathology; the auto‐immune serological markers; the response to corticosteroid/immuno‐suppressive drugs; and the immunogenetic association with HLA B8; DR3. The lifting of the seventh veil, the ultimate understanding of AI‐CAH, will require the following: consensus on criteria for specifying auto‐immune hepatitis as an entity; identification of a liver‐specific auto‐antigen (or hepatocellular neo‐antigen) as target of the immune attack; the nature of the immune effector process which causes hepatocellular destruction; the basis of the deranged immunoregulatory processes expressed as decreased immune suppressor activity; and processes by which ‘anti‐immune’ drugs exert their ameliorative effects. Auto‐immune hepatitis is not unique in the paucity of data on these questions.

show abstract

Liver Disease Due to Infection and Allergy

Cited by 4 publications

References 428 publications

Hepatoimmunology: A perspective

Hepatoimmunology: A perspective

Hypersensitivity Caused by Synthetic Thyroid Hormones in a Hypothyroid Patient With Hashimoto's Thyroiditis

Auto‐immune hepatitis: Lifting the seventh veil

Contact Info

Product

Resources

About