Liver enzymes and risk of diabetes and cardiovascular disease: Results of the Firenze Bagno a Ripoli (FIBAR) study

Monami, Matteo; Bardini, Gianluca; Lamanna, Caterina; Pala, Laura; Cresci, Barbara; Francesconi, Paolo; Buiatti, Eva; Rotella, Carlo Maria; Mannucci, Edoardo

doi:10.1016/j.metabol.2007.10.015

Cited by 111 publications

(78 citation statements)

References 37 publications

(82 reference statements)

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“…The main hypothesis forwarded to explain these results is the observation that in NAFLD group were included patients with different stages of disease severity, and consequently patients with more severe fatty liver disease are those who show elevated liver function test results. These data are in agreement with previously published epidemiological studies that have related serum liver enzymes with atherothrombotic risk profile and elevated risk of cardiovascular disease [30][31][32][33].…”

Section: Controls Nafldsupporting

confidence: 93%

Non-alcoholic fatty liver disease is strongly associated with carotid atherosclerosis: A systematic review

Sookoian

Pirola

2008

Journal of Hepatology

356

243

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Section: Controls Nafldsupporting

confidence: 93%

Non-alcoholic fatty liver disease is strongly associated with carotid atherosclerosis: A systematic review

Sookoian

Pirola

2008

Journal of Hepatology

356

243

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“…In recent years, several studies have investigated the predictive value of liver enzymes, and elevated GGT levels in particular have been found to be significantly correlated with impaired glucose tolerance (3,4). Other studies have demonstrated an increased risk of developing DM in the future in pregnant women with elevated ALT and GGT activities, and that liver steatosis and hepatic insulin resistance play a role in this process (4,17).…”

Section: Discussionmentioning

confidence: 99%

Liver enzymes, mean platelet volume, and red cell distribution width in gestational diabetes

Erdoğan¹,

Özdemir²,

Doğan³

et al. 2014

Turk J Med Sci

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A series of coordination polymers of the general formula {[M(BDC)(azoles)(H 2 O) m ].xH 2 O} n (where M = Co(II), Ni(II), and Cu(II); BDC = 1,4-benzenedicarboxylate; azoles = 2-aminobenzothiazole, 2aminothiazole, and 2-amino-4-methyl-thiazole; m = 0 or 1; and x = 1 or 2) were prepared and characterized.The complexes were characterized based on elemental analysis, infrared and electronic spectral studies, magnetic measurements, molar conductance, thermal analysis, X-ray diffraction, scanning electron microscopy, and biological activity. Thermogravimetry, derivative thermogravimetry, and differential thermal analysis were used to study the thermal decomposition of the complexes. The kinetic parameters were calculated making use of the Coats-Redfern and Horowitz-Metzger equations.

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“…Recently, the FIBAR (Firenze Bagno a Ripoli) study concluded that increased GGT or AST (aspartate aminotransferase) is an independent predictor of CVD. An increase in GGT levels above the reference range, or also in the upper reference range, was also an independent predictor of incident diabetes [35].…”

Section: Relationship With Cvdmentioning

confidence: 92%

Metabolic disturbances in non-alcoholic fatty liver disease

et al. 2009

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NAFLD (non-alcoholic fatty liver disease) refers to a wide spectrum of liver damage, ranging from simple steatosis to NASH (non-alcoholic steatohepatitis), advanced fibrosis and cirrhosis. NAFLD is strongly associated with insulin resistance and is defined by accumulation of liver fat >5% per liver weight in the presence of <10 g of daily alcohol consumption. The exact prevalence of NAFLD is uncertain because of the absence of simple non-invasive diagnostic tests to facilitate an estimate of prevalence. In certain subgroups of patients, such as those with Type 2 diabetes, the prevalence of NAFLD, defined by ultrasound, may be as high as 70%. NASH is an important subgroup within the spectrum of NAFLD that progresses over time with worsening fibrosis and cirrhosis, and is associated with increased risk for cardiovascular disease. It is, therefore, important to understand the pathogenesis of NASH and, in particular, to develop strategies for interventions to treat this condition. Currently, the 'gold standard' for the diagnosis of NASH is liver biopsy, and the need to undertake a biopsy has impeded research in subjects in this field. Limited results suggest that the prevalence of NASH could be as high as 11% in the general population, suggesting there is a worsening future public health problem in this field of medicine. With a burgeoning epidemic of diabetes in an aging population, it is likely that the prevalence of NASH will continue to increase over time as both factors are important risk factors for liver fibrosis. The purpose of this review is to: (i) briefly discuss the epidemiology of NAFLD to describe the magnitude of the future potential public health problem; and (ii) to discuss extra- and intra-hepatic mechanisms contributing to the pathogenesis of NAFLD, a better understanding of which may help in the development of novel treatments for this condition.

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Liver enzymes and risk of diabetes and cardiovascular disease: Results of the Firenze Bagno a Ripoli (FIBAR) study

Cited by 111 publications

References 37 publications

Non-alcoholic fatty liver disease is strongly associated with carotid atherosclerosis: A systematic review

Non-alcoholic fatty liver disease is strongly associated with carotid atherosclerosis: A systematic review

Liver enzymes, mean platelet volume, and red cell distribution width in gestational diabetes

Metabolic disturbances in non-alcoholic fatty liver disease

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