Liver Enzymes Correlate With Metabolic Syndrome, Inflammation, and Endothelial Dysfunction in Prepubertal Children With Obesity

Valle-Martos, Rosario; Valle, Miguel; Martos, Rosario; Cañete, Ramón; Jiménez‐Reina, Luis; Cañete, María Dolores

doi:10.3389/fped.2021.629346

Cited by 23 publications

(14 citation statements)

References 42 publications

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“…These findings are consistent with previous publications stating that obesity is the most frequent cause of hypertransaminasemia in both adults and children ( 20 ). In a cross-sectional study, prepubertal children with obesity were shown to have higher values for transaminase activities than children with normal weight ( 26 ). In another study with 234 obese children aged 6 years and older, 40% even suffered from Non-alcoholic Fatty Liver Disease ( 27 ).…”

Section: Discussionmentioning

confidence: 99%

Liver Involvement in Acute Respiratory Infections in Children and Adolescents – Results of a Non-interventional Study

et al. 2022

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BackgroundIn children and adults with acute respiratory tract infections (ARTI), elevations of serum liver enzyme activities are frequently observed in clinical practice. However, epidemiological data particularly in the pediatric population are very limited. The aim of this study was to assess the incidence of hepatic involvement, to identify the viruses and to analyze risk factors in children and adolescents with ARTI in a real-world setting.MethodsWe report on a prospective, multicenter, non-interventional study with 1,010 consecutive patients aged 1–17 years with ARTI who consulted a physician within 5 days after onset of symptoms. Laboratory blood tests and PCR virus detection in nasopharyngeal lavage were performed at first presentation and after 3–7 days. Patients with elevated activities of serum liver enzymes (ASAT, ALAT, and γ-GT) were determined in local laboratories and values were normalized by dividing by the individual upper limit of the normal range (ULN). The resulting index (<1 means below ULN, >1 means above ULN) allowed to compare results from laboratories with different reference ranges.ResultsLaboratory test results of 987 patients were available at first visit. 11.1% (95% CI: 9.2–13.3%) exhibited an elevation of ASAT, ALAT, and/or γ-GT activities. Virus DNA or RNA was identified in nasopharyngeal lavages of 63% of the patients. 12.2% of patients with positive PCR and 9.7% of those with negative PCR (p = 0.25) had elevated serum liver enzyme activities. The highest rates were observed in patients with a positive result for influenza B virus (24.4%) followed by human metapneumovirus (14.6%), and human coronavirus (others than SARS-CoV-2) (13.6%). The rate of children and adolescents with ARTI and elevation of serum liver enzyme activities correlated with the virus species and with overweight of the patients but did not differ in patients with or without previous medication intake.ConclusionElevated enzyme activities are present in about 10% of children and adolescents with ARTI. In our cohort, these elevations were mild to moderate; probably resulting from an inflammation process with hepatic involvement.

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Section: Discussionmentioning

confidence: 99%

Liver Involvement in Acute Respiratory Infections in Children and Adolescents – Results of a Non-interventional Study

et al. 2022

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“…In line with our results, lower level of serum exosomal miR-320d was found in hepatocellular carcinoma ( 42 ). Based on these evidences, dyslipidemia seems then to moderately contribute to the LD associated dysregulation of cmiR-320 b, while liver dysfunction and inflammation, abundantly interrelated conditions ( 43 ), seem to predict the downregulation of cmiR-320d.…”

Section: Discussionmentioning

confidence: 99%

Circulating Levels of MiRNAs From 320 Family in Subjects With Lipodystrophy: Disclosing Novel Signatures of the Disease

Dattilo

Ceccarini²,

Scabia³

et al. 2022

Front. Endocrinol.

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Lipodystrophy (LD) indicates a group of rare disorders, with generalized or partial loss of white adipose tissue (WAT) often associated with metabolic derangements. Heterogeneity/wide spectrum of the disease and lack of biomarkers make diagnosis often difficult. MicroRNAs are important to maintain a correct WAT function and WAT is a source of circulating miRNAs (cmiRs). miRNAs from 320 family were previously detected in the WAT and variably associated to the metabolic syndrome. Our aim was then to investigate if LD can result in altered abundance of cmiRs-320. We collected samples from a cohort of LD subjects of various subtypes and from age matched controls. Use of quantitative PCR determined that cmiRs- 320a-3p, 320b, 320c, 320e are upregulated, while 320d is downregulated in LD. CmiRs-320 power as classifiers was more powerful in the most extreme and defined forms of LD, including the generalized and the Dunnigan subtypes. cmiR-320a-3p showed significant inverse relationships with plasma leptin (P < 0.0001), typically low in LD. The hepatic enzymes gamma-glutamyl transferase (GGT), aspartate aminotransferase (AST), alanine aminotransferase (ALT) and the marker of inflammation C-reactive protein (CRP) were inversely related to cmiR 320d (P < 0.05, for CRP and GGT; P < 0.01, for AST and ALT). Gene ontology analysis revealed cell-cell adhesion as a process regulated by 320 miRNAs targets, thus disclosing a novel route to investigate origin of WAT loss/dysfunction. In conclusion, cmiRs-320 constitute novel biomarkers of LD, abundance of miR320a-3p is inversely associated to indicators related to WAT function, while downregulation of cmiR-320d predicts an altered hepatic profile and higher inflammation.

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“…Thomas (17) reports that serum cholinesterase activity may be increased in the patients with hepatic steatosis, diabetes mellitus and patients with hyperlipoproteinaemia type IV. Ramirez-Jimenez et al (18), Han et al (19) and Valle-Martos et al (20) described a positive association of an increased plasma BChE activities with triacylglycerols, total cholesterol, LDL-cholesterol, lower HDLcholesterol and metabolic syndrome. The results of the examination of BChE activity in our group of patients with NAFLD showed that the activity of BChE was signifi cantly increased.…”

Section: Discussionmentioning

confidence: 99%

Serum butyrylcholinesterase activities in patients with non-alcoholic fatty liver disease. Comparison with liver proteosynthetic function and liver fibrosis

Turecký¹,

Kupčová²,

Ďurfinová³

et al. 2021

BLL

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BACKGROUND: We aimed to determine how does butyrylcholinesterase (BChE) activity change in the serum of NAFLD patients, whether there was a relationship between BChE and the severity of NAFLD and whether BChE could be used to distinguish the patients with simple hepatic steatosis from the patients with nonalcoholic steatohepatitis. METHODS: The study group consisted of 64 patients with NAFLD. Patients were examined for fatty liver index and in the serum, we investigated BChE activities and the concentrations of prealbumin, cholesterol, HDL-cholesterol, triacylglycerols and hyaluronic acid (HA). We also used FIB-4 index to evaluate liver fi brosis. RESULTS: BChE activity was signifi cantly increased in NAFLD patients compared to the controls (4711 U/l vs 4028 U/l). Patients with higher concentrations of serum triacylglycerols and non-HDL cholesterol had also signifi cantly higher activities of BChE. The comparison of BChE activity and parameters of liver fi brosis (HA and FIB-4) showed a signifi cant negative correlation between these parameters. Patients with an increased concentration of HA had signifi cantly lower BChE than the controls (3111 U/l vs 4028 U/l). CONCLUSIONS: Our results showed increased BChE values in NAFLD patients. The comparison of changes in BChE activity with the changes in prealbumin levels and changes of both fi bro markers showed that the examination of BChE activity could help to differentiate NAFLD patients with a simple hepatic steatosis from those with an advanced disease (Tab. 1, Fig. 7, Ref. 28).

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Liver Enzymes Correlate With Metabolic Syndrome, Inflammation, and Endothelial Dysfunction in Prepubertal Children With Obesity

Cited by 23 publications

References 42 publications

Liver Involvement in Acute Respiratory Infections in Children and Adolescents – Results of a Non-interventional Study

Liver Involvement in Acute Respiratory Infections in Children and Adolescents – Results of a Non-interventional Study

Circulating Levels of MiRNAs From 320 Family in Subjects With Lipodystrophy: Disclosing Novel Signatures of the Disease

Serum butyrylcholinesterase activities in patients with non-alcoholic fatty liver disease. Comparison with liver proteosynthetic function and liver fibrosis

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