Liver enzymes in patients diagnosed with non-alcoholic fatty liver disease (NAFLD) in Veracruz: a comparative analysis with the literature

López-Amador, Noé; Nolasco-Hipólito, Cirilo; Rojas-Jimeno, Macario de J.; Carvajal-Zarrabal, Octavio

doi:10.4172/clinical-investigation.1000107

Cited by 6 publications

(3 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, we evaluated the effect of both HIV infection and genetic factors by conducting a comparison between people living with HIV and Chinese Dai, finding that it increased the chance of the development of MAFLD between 2 and 2.5 times when compared to the genetic factor alone. Moreover, our results agree with previous studies that demonstrated the significant association with PNPLA3 rs738409 and biopsy-proven fibrosis or steatosis among HIV/hepatitis C virus or HBV co-infected patients, HIV-mono infection, and the group with no viral infection[ 33 - 35 ].…”

Section: Discussionsupporting

confidence: 93%

Associations of PNPLA3 and LEP genetic polymorphisms with metabolic-associated fatty liver disease in Thai people living with human immunodeficiency virus

Choochuay,

Kunhapan,

Puangpetch

et al. 2024

World J Hepatol

View full text Add to dashboard Cite

BACKGROUND The prevalence of metabolic-associated fatty liver disease (MAFLD) is a growing public health issue in people living with human immunodeficiency virus (PLWH). However, the pathophysiology of MAFLD is still unknown, and the role of genetic variables is only now becoming evident. AIM To evaluate the associations of gene-polymorphism-related MAFLD in PLWH. METHODS The study employed transient elastography with a controlled attenuation parameter ≥ 248 dB/m to identify MAFLD in patients from a Super Tertiary Hospital in central Thailand. Candidate single-nucleotide polymorphisms (SNPs) were genotyped using TaqMan® MGB probe 5' nuclease assays for seven MAFLD-related genes. Statistical analyses included SNP frequency analysis, Fisher's Exact and Chi-square tests, odds ratio calculations, and multivariable logistic regression. RESULTS The G-allele carriers of PNPLA3 (rs738409) exhibited a two-fold rise in MAFLD, increasing by 2.5 times in MAFLD with human immunodeficiency virus infection. The clinical features and genetic patterns imply that LEP rs7799039 A-allele carriers had a nine times (P = 0.001) more significant chance of developing aberrant triglyceride among PLWH. CONCLUSION The current study shows an association between PNPLA3 rs738409 and LEP rs7799039 with MAFLD in PLWH.

show abstract

Section: Discussionsupporting

confidence: 93%

Associations of PNPLA3 and LEP genetic polymorphisms with metabolic-associated fatty liver disease in Thai people living with human immunodeficiency virus

Choochuay,

Kunhapan,

Puangpetch

et al. 2024

World J Hepatol

View full text Add to dashboard Cite

show abstract

“…Retinoid is primary storage in the liver, about 80% of the total body retinoid stored as retinyl esters in triglyceride-rich lipid droplets in quiescent hepatic stellate cells (HSCs), specialized mesenchymal cells of the liver (30). The HSCs activated and rapidly loss their vitamin A contents in response to liver injury and this process linked to Chronic liver diseases including NAFLD (31,32). It is unclear, the level of hepatic retinoid are reduced in high fat diet, NAFLD (33)(34)(35)(36), and acute liver injury (37).…”

Section: Resultsmentioning

confidence: 99%

Relation of retinol binding protein4, visfatin and vitamin a in obese and non obese Iraqi patients with non alcoholic fatty liver disease

Sattar

AL-Sa’adi

2022

ijhs

View full text Add to dashboard Cite

One of the most common public liver diseases over the world is fatty liver which contain alcoholic and non-alcoholic fatty liver. One-fourth among general population are impact Non-Alcoholic Fatty Liver Disease (NAFLD) in the worldwide.Retinol binding protein 4 (RBP4) is known as an adipokine, mainly synthesized and secreted from the liver and form adipose tissues. RBP4 acts as a transporter and specifically bound to retinol from liver to others tissues. Visfatin is an adipocytokine and mainly produced from visceral fat tissue, skeletal muscles as well as liver. Vitamin A absorbed, transported as retinyl esters to the liver then hydrolyzed to the retinol form and storage in hepatic stellate cells (HSCs) after reesterified with riglycerides. Hepatic retinyl esters are hydrolyzed to retinol and binds to its carrier RBP4 then transport to the target tissues. Methods: Ninety serum blood samples were collected and distributed into three groups: First group (G1) contained of (34) patients of obese NAFLD. Second group (G2) contained of (26) non obese NAFLD and control patients (G3) contained of (30) patients. Ultrasound was used to confirm the diagnosis of nonalcoholic fatty liver disease by examining the abdomen.

show abstract

“…(5) This disorder is characterized by elevated liver enzyme levels, including higher serum glutamic oxaloacetic transaminase/SGOT (also known as alanine aminotransferase/ALT), serum glutamic pyruvic transaminase/SGPT (also known as aspartate aminotransferase/AST), and alkaline phosphatase (ALP), as well as increased triglyceride and cholesterol levels. (6,7) Higher levels of hepatic enzymes and progressive morphological changes in the liver can lead to irreversible liver disease, such as fibrosis and hepatic cirrhosis. (5,8) Statins are drugs used for hypercholesterolemia that reduce steatohepatitis, but not liver fibrosis.…”

Section: Introductionmentioning

confidence: 99%

Protective effect of ethanolic Feronia elephantum Correa fruit extract on high-fat diet induced steatohepatitis in rats

2021

View full text Add to dashboard Cite

BACKGROUND A high-fat diet can lead to hyperlipidemia which will end up as liver damage (steatohepatitis). Ethanolic Feronia elephantum Correa fruit extract (EFEC) has an antioxidant activity which is expected to overcome hyperlipidemia in the liver. The objective of this study was to determine the effects of EFEC on liver function and morphological changes in rats. METHODS This was an experimental study with a post-test only group design. A total of 20 male Wistar rats aged 2-4 months were randomized into 5 groups, A= negative control, B= positive control (high fat diet + 10 mg/kgBW simvastatin), C = high fat diet + 500 mg/kgBW EFEC fruit extract, D = high fat diet + 600 mg/kgBW EFEC, and E = high fat diet + 700 mg/kgBW EFEC). High-fat diet was given for 4 weeks (quail egg yolks, 10ml/200gBW). EFEC was administered for 4 weeks after induction of hypercholesterolemia. Examination of liver serum glutamic oxaloacetic transaminase (SGOT) and serum glutamic pyruvic transaminase (SGPT) was performed on rat blood serum and histopathological examination was carried out using steatohepatitis grading. One way ANOVA test and Post-Hoc Tamhane’s test were used to analyze the data. RESULTS Administration of EFEC at 700 mg/kgBW improved the liver enzymes (p=0.00 for SGPT and SGOT) and steatohepatitis grading in high-fat diet induced rats (mild condition, E = 75% vs A = 100% mild) CONCLUSION Ethanolic Feronia elephantum Correa fruit extract at 700 mg/kgBW was able to improve steatohepatitis in high-fat diet induced rats.

show abstract

Liver enzymes in patients diagnosed with non-alcoholic fatty liver disease (NAFLD) in Veracruz: a comparative analysis with the literature

Cited by 6 publications

References 20 publications

Associations of PNPLA3 and LEP genetic polymorphisms with metabolic-associated fatty liver disease in Thai people living with human immunodeficiency virus

Associations of PNPLA3 and LEP genetic polymorphisms with metabolic-associated fatty liver disease in Thai people living with human immunodeficiency virus

Relation of retinol binding protein4, visfatin and vitamin a in obese and non obese Iraqi patients with non alcoholic fatty liver disease

Protective effect of ethanolic Feronia elephantum Correa fruit extract on high-fat diet induced steatohepatitis in rats

Contact Info

Product

Resources

About