Liver eosinophilic infiltrate is a significant finding in patients with chronic hepatitis C

Tarantino, Giuseppe; Cabibi, Daniela; Cammà, Calogero; Alessi, Nicola; Donatelli, M; Petta, Salvatore; Craxı̀, Antonio; Marco, Vito Di

doi:10.1111/j.1365-2893.2008.00976.x

Cited by 23 publications

(18 citation statements)

References 50 publications

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“…However, the same doses of As(III) elicited severe necrosis in Nrf2 −/− mice with more infiltrated inflammatory cells including eosinophils (Fig 2, liver panel, G and H). This indicates progression to liver disease, since eosinophilic infiltration was recently found to be associated with liver steatosis and liver fibrosis (Tarantino et al , 2008). As expected, there was no significant malignant hyperplasia observed in bladder epithelium in either Nrf2 +/+ or Nrf2 −/− mice following six-weeks of As(III) exposure.…”

Section: Resultsmentioning

confidence: 96%

Nrf2 protects against As(III)-induced damage in mouse liver and bladder

Jiang

Huang

Chan

et al. 2009

Toxicology and Applied Pharmacology

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Arsenic compounds are classified as toxicants and human carcinogens. Environmental exposure to arsenic imposes a big health issue worldwide. Arsenic elicits its toxic efforts through many mechanisms, including generation of reactive oxygen species (ROS). Nrf2 is the primary transcription factor that controls expression of a main cellular antioxidant response, which is required for neutralizing ROS and thus defending cells from exogenous insults. Previously, we demonstrated a protective role of Nrf2 against arsenic-induced toxicity using a cell culture model. In this report, we present evidence that Nrf2 protects against liver and bladder injury in response to six-weeks of arsenic exposure in a mouse model. Nrf2 −/− mice displayed more severe pathological changes in the liver and bladder, compared to Nrf2 +/+ mice. Furthermore, Nrf2 −/− mice were more sensitive to arsenic-induced DNA hypomethylation, oxidative DNA damage, and apoptotic cell death. These results indicate a protective role of Nrf2 against arsenic toxicity in vivo. Hence, this work demonstrates the feasibility of using dietary compounds that target activation of the Nrf2 signaling pathway to alleviate arsenic-induced damage.

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Section: Resultsmentioning

confidence: 96%

Nrf2 protects against As(III)-induced damage in mouse liver and bladder

Jiang

Huang

Chan

et al. 2009

Toxicology and Applied Pharmacology

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“…The location and the consequences of eosinophilic infiltration of the liver depends on the inflammation focus or disease condition. In biopsies from individuals with chronic hepatitis C the number of these cells was greater in the larger portal tracts and strongly associated with liver steatosis and fibrosis [ 132 ]. In a drug-induced liver injury (DILI), the role for eosinophil is controversial.…”

Section: Differential Location Of Immune Cells Throughout the Livementioning

confidence: 99%

Differential Location and Distribution of Hepatic Immune Cells

Freitas-Lopes

Mafra

David

et al. 2017

Cells

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The liver is one of the main organs in the body, performing several metabolic and immunological functions that are indispensable to the organism. The liver is strategically positioned in the abdominal cavity between the intestine and the systemic circulation. Due to its location, the liver is continually exposed to nutritional insults, microbiota products from the intestinal tract, and to toxic substances. Hepatocytes are the major functional constituents of the hepatic lobes, and perform most of the liver’s secretory and synthesizing functions, although another important cell population sustains the vitality of the organ: the hepatic immune cells. Liver immune cells play a fundamental role in host immune responses and exquisite mechanisms are necessary to govern the density and the location of the different hepatic leukocytes. Here we discuss the location of these pivotal cells within the different liver compartments, and how their frequency and tissular location can dictate the fate of liver immune responses.

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“…These cells are frequently associated with Th2 responses in a number of pathological conditions, being major constituents of the inflammatory infiltrate in the lungs of asthmatics and in patients with chronic obstructive pulmonary disease (7)(8)(9)(10). There is also a growing literature demonstrating eosinophilia in a number of liver diseases (1,2,(11)(12)(13)(14)(15).…”

Section: Cutting Edge: Eosinophils Undergo Caspase-1-mediated Pyroptomentioning

confidence: 99%

Cutting Edge: Eosinophils Undergo Caspase-1–Mediated Pyroptosis in Response to Necrotic Liver Cells

Palacios-Macapagal¹,

Connor²,

Mustelin³

et al. 2017

The Journal of Immunology

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Many chronic liver disorders are characterized by dysregulated immune responses and hepatocyte death. We used an in vivo model to study the immune response to necrotic liver injury and found that necrotic liver cells induced eosinophil recruitment. Necrotic liver induced eosinophil IL-1β and IL-18 secretion, degranulation, and cell death. Caspase-1 inhibitors blocked all of these responses. Caspase-1-mediated cell death with accompanying cytokine release is the hallmark of a novel form of cell death termed pyroptosis. To confirm this response in a disease model, we isolated eosinophils from the livers of -infected mice. eggs lodge in the hepatic sinusoids of infected mice, resulting in hepatocyte death, inflammation, and progressive liver fibrosis. This response is typified by massive eosinophilia, and we were able to confirm pyroptosis in the infiltrating eosinophils. This demonstrated that pyroptosis is a cellular pathway used by eosinophils in response to large-scale hepatic cell death.

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Liver eosinophilic infiltrate is a significant finding in patients with chronic hepatitis C

Cited by 23 publications

References 50 publications

Nrf2 protects against As(III)-induced damage in mouse liver and bladder

Nrf2 protects against As(III)-induced damage in mouse liver and bladder

Differential Location and Distribution of Hepatic Immune Cells

Cutting Edge: Eosinophils Undergo Caspase-1–Mediated Pyroptosis in Response to Necrotic Liver Cells

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