Liver fibrosis is associated with cutaneous inflammation in the imiquimod-induced murine model of psoriasiform dermatitis

Abstract

These results indicate that liver inflammation and fibrosis are associated with experimental psoriasiform dermatitis. Our results suggest that psoriatic inflammation may be associated with specific liver injury.

IRE1α/NOX4 signaling pathway mediates ROS‐dependent activation of hepatic stellate cells in NaAsO2‐induced liver fibrosis

“…In response to profibrotic stimulus, the quiescent HSCs will transform into activated fibrogenic myofibroblasts with a characteristic increase of Collagen‐1 and α‐SMA and release of lipid droplets (Hernandez‐Gea & Friedman, 2012; Kisseleva, 2017). It is well known that inflammation and oxidative stress serve as an inducer to liver fibrosis and HSCs activation (Fabregat et al, 2016; Vasseur et al, 2018). Moreover, our previous study has demonstrated the crucial role of the inflammatory response in HSCs activation during NaAsO 2 exposure (Tao et al, 2019).…”

Aldara-induced dermatitis is associated with development of liver fibrosis in mice

“…This study provides additional evidence that psoriasis contributes to the development of liver fibrosis . Effective management of psoriasis may go beyond improving skin disease and contribute to better long‐term, liver‐related patient outcomes.…”

“…All mice were assessed with an adapted PASI score, liver function tests and liver histopathology (the primary outcome). The Aldara‐treated mice had a significantly higher mean aspartate aminotransferase ( P = 0·001) and a significantly greater surface area of hepatic collagen deposition (indicating liver fibrosis) compared with the control group ( P = 0·02) …”

“…Does psoriasis cause liver fibrosis? In this issue of the BJD , Vasseur et al . publish data to suggest that, in mice, cutaneous inflammation induced by repetitive applications of imiquimod‐containing Aldara cream is associated with the development of hepatitis and liver fibrosis.…”

“…This study supports their finding. What is new is that Vasseur et al . are the first to show development of liver fibrosis associated with cutaneous inflammation induced by Aldara.…”