Liver function in physically trained subjects

Abstract

Physical exercise and physical training are known to affect several aspects of hepatic metabolism. To assess whether adaptation to long-lasting exercise modifies microsomal drug metabolism, 8 long-distance runners were compared with a group of medical students having significantly lower maximal rates of oxygen consumption. At rest the hepatic galactose elimination capacity and the indocyanine green plasma disappearance rate used as reference methods were the same in both groups. The plasma clearance of ([14C]dimethylamine) aminopyrine and the kinetics of 14CO2 in breath did not differ either. It is concluded that adaptation to long-lasting exercise can occur without evidence for changes in hepatic galactokinase activity, liver blood flow, or microsomal metabolism of aminopyrine.

A Review of Psychophysiological Stressors on Pharmacokinetics

“…For example, compared with acute exercise, 49 , 56 endurance training had no statistically significant effects (n = 43; P > .05) on propranolol regarding maximal concentration, time of maximal concentration, terminal half‐life, area under the curve, and protein binding 57 . Similarly, there were also differences in the effects of chronic exercise on the same drug (aminopyrine), which was ascribed to dietary contents, 114 but it could also result from different types of training (gymnastic versus running) which may induce biological changes, in particular hepatic functions, to various extents 44 , 45 . Future research could clarify these potential confounding factors.…”