Liver Function

Cornelius, Charles E.

doi:10.1016/b978-0-12-396301-7.50012-0

Cited by 39 publications

(39 citation statements)

References 128 publications

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“…Hepatic necrosis may cause hypoglycemia because the remaining hepatic tissue may be insufϐicient to maintain adequate glycemic control (Colodel et al 2000). Biochemical analysis of the blood was consistent with hepatic lesions, i.e., GGT and AST values were considerably elevated in the affected an imals (Cornelius 1989). Similar AST serum proϐiles have been described for P. ϔlavipes larvae toxicity in pigs (Soares et al 2001).…”

Section: Discussionsupporting

confidence: 59%

Perreyia flavipes larvae toxicity

et al. 2012

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Pesq. Vet. Bras. 32(8) Unique do ses of 7.5 and 10mg/kg induced characteristic clinical signs of Perreyia sp. larvae poisoning, increased GGT and AST values, and decreased glycemic curves. However, doses of 5, 10, and 15mg/kg repeated at 30 or 15 days intervals caused no disease and mild disease followed by death, respectively. These ϐin dings indicate that these animals probably developed some degree of tolerance to the toxins in P. ϔlavipes larvae. Ultrastru ctural examination of liver revealed proliferation of the smooth endoplasmic reticulum in the hepatocytes, which may be associated with an increased ability to metabolize toxins and could consequently lead to the tolerance observed in the present study. Further investigations may elucidate whether such tolerance effects could be applied as a control measure for P. ϔlavipes poioning or other hepatotoxic diseases. In addition, clinicopathological ϐindings were discussed. algum grau de tolerância para as toxinas presentes nas larvas de P. ϔlavipes. O exame ultraestrutural do ϐígado revelou proliferação do retículo endoplasmático liso de hepatóci-tos, o que pode ser associado a um aumento na capacidade de metabolizar toxinas e conseqüentemente levar à tolerância observada no presente estudo. Outras investigações poderão esclarecer se os efeitos de tal tolerância poderiam ser aplicados como medida de controle da intoxicação por P. ϔlavipes ou outras doenças hepatotóxicas. Além disso, os resultados clínico-patológicos foram discutidos.

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Section: Discussionsupporting

confidence: 59%

Perreyia flavipes larvae toxicity

et al. 2012

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“…According to Blum et al (1970), serum albumin level is closely correlated to liver size. Cornelius (1970) advances a similar opinion. Nir (1972) found a significant negative correlation between liver weight and serum protein (r=-0.341) and serum albumin (r = &horbar;0.543).…”

Section: Introductionsupporting

confidence: 53%

Correlation between liver weight and blood serum biochemical parameters in force fed interspecific hybrid ducks

Csuka¹,

Kindlova²,

Staško³

1977

Ann. Biol. anim. Bioch. Biophys.

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Summary. lnterspecific hybrid ducks, obtained by crossing domestic with Muscovy, are crammed and compared to controls. Cramming causes significant differences in the blood serum GOT, GPT, cholesterol and amylase levels. Significant differences in the major parameters are also found between large-liver and small-liver animals and with high weight gain or low gain.The following correlations are : liver size and GOT, r = + 0.583 ; liver size and GPT, r = + 0.490 ; liver size and cholesterol, r = + 0.324. The correlation between relative gain during force feeding and GOT level is r = + 0.483 ; between that gain and GPT it is r = + 0.421.

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“…The enzymes such as the ones assessed in the present study catalyze such anabolic and catabolic activities. ALP levels, for instance, have been shown to increase in situations of increased osteoblastic and biliary activities (Robbins et al, 1984;Cornelius, 1989).…”

Section: Discussionmentioning

confidence: 99%