Liver function tests as predictors of common bile duct stones in acute cholecystitis patients with a chronic history

Zgheib, Hady; Wakil, Cynthia; Souky, Nader Al; Mailhac, Aurélie; Jamali, Faek; Sayed, Mazen El; Tamim, Hani

doi:10.1097/md.0000000000026885

Cited by 8 publications

(4 citation statements)

References 20 publications

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“…6 Among CBD stones patients 71.1% were above 40 years of age group and 75.6% were female similar to findings in study by Zgheib H etal. 7 Similar demographic pattern was also seen by Song Y et al and Hosseini SV et alfrom China and Iran. Although there was a marked geographical variation in prevalence of biliary stone disease, it was more common in female and with increasing age of people.…”

Section: Discussionsupporting

confidence: 76%

Analysis of Liver Function Test in Common Bile Duct Stone: A Descriptive Cross sectional study

Pun,

Dhungana,

Shrestha

et al. 2023

J Coll Med Sci-Nepal

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Introduction: Liver function test (LFT) is a useful tool to differentiate between the obstructive and hepatocellular cause for biliary obstruction. Therefore this study was done to see the accuracy of LFT in predicting common bile duct (CBD) stones. Methods: A descriptive cross sectional study was carried out on patient undergoing endoscopic retrograde cholangiopancreatography for CBD stones at Bharatpur Hospital and Dev Hospital from 2021 June 15 to 2022 October 15. Ethical clearance was taken from Institutional Review Committee Bharatpur Hospital reference number 079/80-013. The convenient sampling method was applied. Data were collected and analyzed in statistical package for the social sciences version 22. Results: Out of 95 patients higher aged female predominance was seen. The overall incidence of abnormal LFT in CBD stones was 85.3%. All the parameters of LFT were raised in majority of the cases of CBD stones and among these, SGOT was mostly increased (75.6%). In patients with ERCP findings of sludge in bile duct have increased total, direct and indirect bilirubin than in patient with CBD stone and this finding was found to be statistically significant. However, other liver parameters were comparable.Similarly, total, direct and indirect bilirubin, serum glutamic oxaloacetic transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT) and alkaline phosphatase (ALP) were equally raised with both group of CBD stones with and without cholecystitis. Conclusion: Liver function test was equally raised in both case of CBD stone with and without cholecystitis. Although ALP and total bilirubin represented the most reliable predictors in obstructive jaundice, SGOT might also be added tool to exclude choledocholithiasis.

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Section: Discussionsupporting

confidence: 76%

Analysis of Liver Function Test in Common Bile Duct Stone: A Descriptive Cross sectional study

Pun,

Dhungana,

Shrestha

et al. 2023

J Coll Med Sci-Nepal

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“…Small-incision cholecystectomy, modified from traditional open surgery, reduces the surgical incision and the risk of infection [13] but is limited by its narrow intraoperative field. Clinical research has confirmed that laparoscopic cholecystectomy provides the larger Evidence-Based Complementary and Alternative Medicine surgical field and contributes to the rapid removal of the lesion, significantly shortens the operative time and postoperative hospital stay, and promotes postoperative recovery [14]. A study by Alexander et al suggested that laparoscopic cholecystectomy is less prone to medically induced injury to the gastrointestinal wall, greater omentum, and peritoneum during the operation and avoids intraoperative hemorrhage [15], and the closure of the gallbladder artery using an absorbable clip during the procedure significantly reduces intraoperative bleeding volume [16].…”

Section: Discussionmentioning

confidence: 99%

Effectiveness of Laparoscopic Cholecystectomy in Patients with Gallbladder Stones with Chronic Cholecystitis

Rao

Zhou

Gao

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Objective. To assess the effectiveness of laparoscopic cholecystectomy in patients with gallbladder stones and chronic cholecystitis. Methods. From July 2018 to January 2020, 90 patients with gallbladder stones and chronic cholecystitis assessed for eligibility were recruited and concurrently assigned (1 : 1) to receive either small-incision cholecystectomy (observation group) or laparoscopic cholecystectomy (experimental group). Outcome measures included operation time, intraoperative bleeding volume, postoperative hospital stay, c-reactive protein (CRP), interleukin (IL)-6, tumor necrosis factor-α (TNF-α), gastrin (GAS), vasoactive intestinal peptide (VIP), motilin (MOT), and adverse events. Results. Patients given laparoscopic cholecystectomy showed lower levels of operation-related indices versus those receiving small-incision cholecystectomy ( P < 0.05 ). Laparoscopic cholecystectomy resulted in lower postoperative levels of CRP, IL-6, and TNF-α in the patients versus small-incision cholecystectomy ( P < 0.05 ). Patients receiving laparoscopic cholecystectomy showed better GAS, VIP, and MOT levels than those receiving small-incision cholecystectomy ( P < 0.05 ). The eligible patients after laparoscopic cholecystectomy had a significantly lower incidence of adverse events versus those after small-incision cholecystectomy ( P < 0.05 ). Conclusion. Laparoscopic cholecystectomy effectively shortens the operative time and length of hospital stay in patients with gallbladder stones and chronic cholecystitis, reduces intraoperative bleeding, attenuates the inflammatory response, and enhances the gastrointestinal function, with less surgical trauma and high safety. Clinical trials are, however, required prior to promotion.

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“…In patients with GS combined with CBDS, significantly elevated levels of serum AST, ALT, and TBIL were observed. This finding may be attributed to the impact of artificial pneumoperitoneum during surgery on hepatic tissue hemodynamics and subsequent reduction in blood flow through the hepatic artery and portal vein leading to impaired liver function[ 28 ]. In addition, a meta-analysis found that CBDS was the most common etiology for significantly elevated ALT levels (> 500 IU/L), and that approximately one-third of patients with CBDS would present with ALT or AST > 500 IU/L[ 29 ].…”

Section: Discussionmentioning

confidence: 99%

Clinical efficacy of laparoscopic cholecystectomy combined with endoscopic papillary balloon dilation in treatment of gallbladder stones with common bile duct stones: A retrospective study

Liu,

Zhang,

et al. 2024

World J Gastrointest Surg

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BACKGROUND The incidence of cholelithiasis has been on the rise in recent years, but the choice of procedure is controversial. AIM To investigate the efficacy of laparoscopic cholecystectomy (LC) combined with endoscopic papillary balloon dilation (EPBD) in patients with gallbladder stones (GS) with common bile duct stones (CBDS). METHODS The clinical data of 102 patients with GS combined with CBDS were selected for retrospective analysis and divided into either an LC + EPBD group (n = 50) or an LC + endoscopic sphincterotomy (EST) group (n = 52) according to surgical methods. Surgery-related indexes, postoperative recovery, postoperative complications, and expression levels of inflammatory response indexes were compared between the two groups. RESULTS Total surgical time, stone free rate, rate of conversion to laparotomy, and successful stone extraction rate did not differ significantly between the LC + EPBD group and LC + EST group. Intraoperative hemorrhage, time to ambulation, and length of hospitalization in the LC + EPBD group were lower than those of the LC + EST group (P < 0.05). The rate of total complications of the two groups was 9.80% and 17.65%, respectively, and the difference was not statistically significant. No serious complications occurred in either group. At 48 h postoperatively, the expression levels of interleukin-6, tumor necrosis factor-α, high-sensitivity C-reactive protein, and procalcitonin were lower in the LC + EPBD group than in the LC + EST group (P < 0.05). At 3 d postoperatively, the expression levels of aspartate transaminase, alanine transaminase, and total bilirubin were lower in the LC + EPBD group than in the LC + EST group (P < 0.05). CONCLUSION LC combined with EPBD and LC combined with EST are both effective procedures for the treatment of GS with CBDS, in which LC combined with EPBD is beneficial to shorten the patient’s hospitalization time, reduce the magnitude of elevated inflammatory response indexes, and promote postoperative recovery.

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Liver function tests as predictors of common bile duct stones in acute cholecystitis patients with a chronic history

Abstract: Supplemental Digital Content is available in the text

Cited by 8 publications

References 20 publications

Analysis of Liver Function Test in Common Bile Duct Stone: A Descriptive Cross sectional study

Analysis of Liver Function Test in Common Bile Duct Stone: A Descriptive Cross sectional study

Effectiveness of Laparoscopic Cholecystectomy in Patients with Gallbladder Stones with Chronic Cholecystitis

Clinical efficacy of laparoscopic cholecystectomy combined with endoscopic papillary balloon dilation in treatment of gallbladder stones with common bile duct stones: A retrospective study

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