Liver hydrolysate prevents depressive-like behavior in an animal model of colitis: Involvement of hippocampal neurogenesis via the AMPK/BDNF pathway

Nakagawasai, Osamu; Yamada, Kotaro; Takahashi, Kohei; Odaira, Takayo; Sakuma, Wakana; Ishizawa, Daisuke; Takahashi, Naruya; Onuma, Kentaro; Hozumi, Chikako; Nemoto, Wataru; Tan-No, Koichi

doi:10.1016/j.bbr.2020.112640

Cited by 26 publications

(23 citation statements)

References 58 publications

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“…5 Recent studies in rodents demonstrate that DSS-induced anxiety-like and depressive-like behaviors are related to neuroinflammation, apoptosis, activation of microglia and astrocytes, oxidative stress and synaptic impairments in addition to the levels of BDNF. [6][7][8][9][10] Yet, few studies reveal the underlying neurobiological mechanism in the impact of IBD on anxiety-like and depressive-like behavior, and multiple mechanisms should be investigated.…”

Section: Introductionmentioning

confidence: 99%

Sesamol ameliorates dextran sulfate sodium-induced depression-like and anxiety-like behaviors in colitis mice: the potential involvement of the gut–brain axis

Xia

Liu

et al. 2022

Food Funct.

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Section: Introductionmentioning

confidence: 99%

Sesamol ameliorates dextran sulfate sodium-induced depression-like and anxiety-like behaviors in colitis mice: the potential involvement of the gut–brain axis

Xia

Liu

et al. 2022

Food Funct.

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“…Olfactory dysfunction is considered a premotor sign of neurodegeneration that appears early in the degenerative process as in Alzheimer disease and Parkinson disease (30,31). Moreover, the olfactory bulbectomy of rats has been validated as a model of depression over the past 30 years, suggesting a close relationship between MOB and depression (15)(16)(17). Reviewing literature showed that the, pathophysiology of MOB induced by CUMS is still unclear.…”

Section: Discussionmentioning

confidence: 99%

“…Although the relationship between MOB and depression was recently reported (15)(16)(17), the CUMS-induced dysfunction of MOB is not clearly described. Therefore, the current research was designed to evaluate the CUMS-induced alterations occurred in MOB in mice exposed to mild chronic depression and the efficacy of inhalation of O. basilicum essential oils in improving these changes as well as understand the possible mechanism underlying this effect.…”

Section: Introductionmentioning

confidence: 98%

Ocimum basilicum (Basil) Modulates Apoptosis and Neurogenesis in Olfactory Pulp of Mice Exposed to Chronic Unpredictable Mild Stress

et al. 2020

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Background: Ocimum basilicum (O. basilicum) was described to have antidepressant and anxiolytic activities. Although the relationship between the main olfactory bulb (MOB) and depression was recently reported, the chronic stress-induced dysfunction of the MOB is not clearly described. Objectives: This study aimed to assess the efficacy of inhalation of O. basilicum essential oils in improving chronic unpredictable mild stress (CUMS)-induced changes in MOB of mice and understand the mechanism underlying such effect. Materials and Methods: Adult male mice (n=40) were assigned into four groups included the control, CUMS-exposed, CUMS + fluoxetine (FLU), CUMS + O. basilicum. Behavioral changes, serum corticosterone level, and gene expression of GFAP, Ki 67, and caspase-3 were assessed using real-time PCR (RT-PCR). Histopathological and immunochemical examination of the MOB was performed. Results: FLU and O. basilicum significantly down-regulated (p = 0.002, p<0.001) caspase-3 gene expression indicating reduced apoptosis and up-regulated (p = 0.002, p < 0.001) Ki67 gene expression indicating enhanced neurogenesis in MOB, respectively. FLU and O. basilicum-treated mice markedly improved MOB mitral cell layer distortion and shrinkage induced by CUMS. Conclusion: O. basilicum relieved both biochemically and histopathological chronic stress-induced changes in the main olfactory bulb possibly through up-regulation of gene expression of GFAP and Ki67 and down-regulation of caspase-3 in the MOB.

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“…TST was performed 4 weeks after modelling and 2 weeks after drug administration as described (Nakagawasai et al. 2020 ). Mice were hung upside down on the tail suspension instrument in a quiet environment.…”

Section: Methodsmentioning

confidence: 99%

“…The purpose of the tail immobility time (tail suspension test, TST) was to verify the model and evaluate drug efficacy. TST was performed 4 weeks after modelling and 2 weeks after drug administration as described (Nakagawasai et al 2020). Mice were hung upside down on the tail suspension instrument in a quiet environment.…”

Section: Behavioural Testsmentioning

confidence: 99%

Antidepressant effects of total iridoids of Valeriana jatamansi via the intestinal flora-blood–brain barrier pathway

Zhang

Wang

Huang

et al. 2021

Pharmaceutical Biology

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Context: Valeriana jatamansi Jones [syn. V. wallichii DC, (Valerianaceae)] (VJJ) is used to treat depression. Objective: To explore the effects of total iridoids of VJJ extract (TIV) on chronic unpredictable mild stress (CUMS) in mice. Materials and methods: VJJ roots and rhizomes were extracted with 70% ethanol. CUMS rats were treated daily with fluoxetine (2.6 mg/kg, i.g.) or TIV (5.7, 11.4, and 22.8 mg/kg, i.g.) for 14 days. Male Kun Ming mice on normal chow and 0.5% CMC-Na solution were used as a control. Behavioural tests included the tail suspension (TST) and sucrose preference tests (SPT). Evans blue staining was used to evaluate blood-brain barrier (BBB) permeability. Western blotting was used to measure zonula occludens-1 (ZO-1) and occludin expression. 16S rRNA sequencing was used to analyse intestinal flora abundance. Tax4Fun was used to predict KEGG metabolic pathways. Results: TIV treatment reduced TST time (117.35 ± 8.23 or 108.95 ± 6.76 vs. 144.45 ± 10.30 s), increased SPT (55.83 ± 7.24 or 53.12 ± 13.85 vs. 38.98 ± 5.43%), increased the abundance of phylum Firmicutes (86.99 ± 0.03 vs. 60.88 ± 0.19%) and genus Lactobacillus (75.20 ± 0.19 vs. 62.10 ± 0.13%), reduced the abundance of phylum Bacteroidetes (6.69 ± 0.06 or 11.50 ± 0.09 vs. 25.07 ± 0.20%). TIV increased carbohydrate metabolism (14.50 ± 3.00 Â 10 À3 or 14.60 ± 2.00 Â 10 À3 or 14.90 ± 2.00 Â 10 À3 vs.13.80 ± 4.00 Â 10 À3 %), replication and repair functions (5.60 ± 1.00 Â 10 À3 or 5.60 ± 1.00 Â 10 À3 vs. 5.10 ± 4.00 Â 10 À3 %), reduced the frequency of infectious disease (1.60 ± 2.00 Â 10 À4 or 1.90 ± 5.00 Â 10 À4 or 1.80 ± 3.00 Â 10 À4 vs. 2.20 ± 7.00 Â 10 À3 %), BBB permeability (0.77 ± 0.30 vs. 1.81 ± 0.33 lg/g), and up-regulated the expression of ZO-1 (1.42-fold, 1.60-fold, 1.71-fold) and occludin (1.79-fold, 2.20-fold). Conclusions: TIV may modulate the intestinal flora, thereby inducing the expression of ZO-1 and occludin, protecting the BBB and exerting an antidepressant effect.

show abstract

Liver hydrolysate prevents depressive-like behavior in an animal model of colitis: Involvement of hippocampal neurogenesis via the AMPK/BDNF pathway

Cited by 26 publications

References 58 publications

Sesamol ameliorates dextran sulfate sodium-induced depression-like and anxiety-like behaviors in colitis mice: the potential involvement of the gut–brain axis

Sesamol ameliorates dextran sulfate sodium-induced depression-like and anxiety-like behaviors in colitis mice: the potential involvement of the gut–brain axis

Ocimum basilicum (Basil) Modulates Apoptosis and Neurogenesis in Olfactory Pulp of Mice Exposed to Chronic Unpredictable Mild Stress

Antidepressant effects of total iridoids of Valeriana jatamansi via the intestinal flora-blood–brain barrier pathway

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