Liver hypertrophy in winter flounder following exposure to experimentally oiled sediments

Influence of Hydrocarbons Exposure on Survival, Growth and Condition of Juvenile Flatfish: A Mesocosm Experiment

“…PAHs are regarded as priority contaminants of terrestrial as well as marine ecosystems (that is, PAHs are listed in the OSPAR list of chemical for priority action) because of their mutagenic and carcinogenic activity. Direct effects of hydrocarbon exposure on adult fishes have been well documented in laboratory (Fletcher et al 1982;Heintz et al 2000;Payne and Fancey 1989) or in field studies, following a spill (Bue et al 1998;Haensly et al 1982) in polluted estuaries (Heintz 2007;Johnson et al 1998) or in relation with oil platforms (Stagg et al 1995). These effects include the induction of detoxification process, tissue alterations and functional abnormalities.…”

Third report on the Oak Ridge K-25 Site Biological Monitoring and Abatement Program for Mitchell Branch

“…toxicant stress, and liver enlargement resulting fkom hyperplasia (increase in cell number), and hypertrophy (increase in cell size) has been reported in fish exposed to toxic compounds (Fletcher et al 1982, Heath 1987, Addison 1984. A different set of indicators were important, however, in 1990 for among-site discrimination.…”

Remedial investigation/feasibility study for the Clinch River/Poplar Creek operable unit. Volume 1. Main text

“…The liver-somatic index &SI) is an indicator of metabolic energy demands (Adams and M c h 1985) and is Sensitive to toxicant stress with both liver enlargement due to hyperplasia and hypertrophy being reported in fish exposed to toxic compounds (Fletcher et al 1982, Addison 1988, H e a t h 1987). Largemouth bass sampled fiom all Clinch River sites except CRM 10 and all Poplar Creek sites had sigdiwntly lower LSI values than the Watts Bar reference bass (Fig.…”