Liver injury after an aggressive encounter in male mice

Sánchez, Olga; Viladrich, M. C.; Ramı́rez, Ignasi; Soley, Maria

doi:10.1152/ajpregu.00113.2007

Cited by 28 publications

(30 citation statements)

References 62 publications

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“…We can therefore not rule out the possibility that anticipatory appraisal of the CAPS interview as overly threatening might have elicited an increase in liver enzymes in relation to PTSD severity. Our finding of PTSD predicting circulating levels of hepatic enzymes are in accordance with considerably consistent literature about psychological stress causing liver injury and an increase in hepatic enzymes in rodents [4][5][6][7]. Our data also concur with cross-sectional associations between chronic life stress and the degree of chronic hepatitis and ALT levels in humans [9,10].…”

Section: Discussionsupporting

confidence: 92%

“…However, PTSD patients have a greater degree of sympathetic nervous system activation [11]. In rats, transaminases were significantly increased 3 h after acute psychological stress [4]. We can therefore not rule out the possibility that anticipatory appraisal of the CAPS interview as overly threatening might have elicited an increase in liver enzymes in relation to PTSD severity.…”

Section: Discussionmentioning

confidence: 93%

“…For instance, an aggressive encounter in male mice caused increased plasma activities of ALT and AST after 3 h as well as necrotic lesions of the liver parenchyma and damage to hepatocytes 8 h later [4]. Electron microscopy showed autophagy of the liver compatible with hepatic damage 2 days after exposure of rats to a variety of acute stressors, including restraint stress [5].…”

Section: Introductionmentioning

confidence: 99%

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Association Between Posttraumatic Stress Disorder Following Myocardial Infarction and Liver Enzyme Levels: A Prospective Study

et al. 2009

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

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Association Between Posttraumatic Stress Disorder Following Myocardial Infarction and Liver Enzyme Levels: A Prospective Study

et al. 2009

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“…The results of these studies showed that the experimental exposure of guinea pigs to psychological stress had a negative impact on the liver and the effect was even more pronounced in animals with pre-existing liver or cardiovascular diseases. Sanchez et al in 2007 described the development, in lab male mice, of an increase in plasma concentrations of ALT and AST after three hours of exposure to severe psychological stress and the occurrence of necrotic lesions of the parenchyma with damages of liver hepatocytes after 8 hours of exposure (66). Similar results were obtained by other Authors, such as Salas et al who described through electron microscopy the development of liver autophagic reactions compatible with liver injury in guinea pigs after 2 days of acute exposure to different varieties of psychological stressor (67).…”

Section: Comparing the Results Of The Questionnaire Hse And Liver Parmentioning

confidence: 99%

Perceived stress and hepatic parameters

Tomei¹

2016

PER

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Introduction: the aim of the study is to evaluate work-related subjective stress in a group of employees, of both sexes, operating in the healthcare and welfare, through the administration of a questionnaire (HSE "Indicator Tool"), specifically developed and officially validated, and to analyze any possible correlations between stress levels taken from the questionnaire scores and the concentrations of three main hepatic parameters (GOT, GPT, GGT). Materials and methods: we studied a final sample of 232 subjects (143 males and 89 females) operating in the health and welfare sector. For research purposes during the medical examination each subject underwent the HSE indicator tool, a collection of information about relevant clinical and medical history and a venous blood sample for the assay of GOT, GPT and GGT. All questionnaires were analyzed using special software provided by the HSE. The results obtained from the questionnaires were statistically compared with the blood concentrations of hepatic parameters. Results: the dimensions found to be critical, associated with a stressful condition (yellow area) or a highly stressful condition (red area), are: managers support, colleagues support, quality of relationships and changes. The Pearson's correlation showed a statistically significant negative correlation (p <0.05) between the mean values of all the critical dimensions and the concentrations of the hepatic parameters, both on the total sample and after subdivision by gender. These results were confirmed in the multiple linear regression analysis, which indicated that the critical dimensions are the main significant variables contributing to the liver parameters alterations. Discussion: preliminary results indicate that a critical perception of stress at work can be statistically associated with increases in mean concentrations of GOT, GPT and GGT in a working asymptomatic population. These results provide a starting point for future studies on this topic, to a greater definition of the link between stress and liver injury, to confirm the effects on the parameters of liver injury (GOT, GPT, GGT) and to investigate possible correlations with the cholestasis parameters (bilirubin, alkaline phosphatase) and serum albumin.

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“…These glands release EGF into the saliva and blood plasma upon acute α 1 -adrenergic stimulation [6]. Accordingly, several stressors increase the EGF concentration in the plasma of male mice [13, 38,47,48].…”

Section: Introductionmentioning

confidence: 99%

Submandibular salivary glands: influence on growth rate and life span in mice

Ramı́rez

Soley

2010

J Physiol Biochem

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Submandibular glands accumulate a variety of growth factors, especially in male mice. Surgical excision of these glands (sialoadenectomy) results in alterations in several organs and systems including the liver, skin and reproductive system. We studied the life-long consequences of sialoadenectomy in male mice. Animals were operated at the age of 10 weeks. Thereafter, body weight and food and water intake were controlled until death. Few weeks after surgery, body weight was lower in sialoadenectomized than in control mice. The difference remained stable until the age of 80 weeks. In spite of the lower body weight, food intake was higher in sialoadenectomized mice than in controls. The first death of sialoadenectomized mice occurred 10 weeks earlier than that of the first control, and the initial death rate in sialoadenectomized mice was almost twice the rate in controls. After 100 weeks of life, the death rate increased in control mice, but suddenly decreased in sialoadenectomized mice. The consequence was that the mean life span of the last 25% surviving animals was 10 weeks longer in sialoadenectomized than in control mice. Autopsy examination suggests that the effect of sialoadenectomy on death rate may be the consequence of a contrasting effect on tumour growth. Our results indicate that submandibular glands, or rather the factors derived from these glands, have contrasting roles in tumour growth. At early ages they may be survival factors and protect tissues, whereas at later ages they may stimulate the growth of transformed cells.

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Liver injury after an aggressive encounter in male mice

Abstract: Sánchez O, Viladrich M, Ramírez I, Soley M. Liver injury after an aggressive encounter in male mice.

Cited by 28 publications

References 62 publications

Association Between Posttraumatic Stress Disorder Following Myocardial Infarction and Liver Enzyme Levels: A Prospective Study

Association Between Posttraumatic Stress Disorder Following Myocardial Infarction and Liver Enzyme Levels: A Prospective Study

Perceived stress and hepatic parameters

Submandibular salivary glands: influence on growth rate and life span in mice

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