Liver Injury Following Renal Ischemia Reperfusion in Rats

Wang, B.; Bai, Ming; Bai, Yu-Mei; Li, Q.

doi:10.1016/j.transproceed.2010.09.008

Cited by 23 publications

(21 citation statements)

References 8 publications

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“…The release of AST and ALT and LDH into the plasma refl ected mostly the damages to hepatocyte. These results are in accordance with previous studies, showing that renal ischemia remotely causes detrimental changes in the function of liver (1,10).…”

Section: Discussionsupporting

confidence: 94%

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Hepatoprotective effects of remote perconditioning during renal ischemia

Sedaghat¹,

Kadkhodaee²,

Seifi³

et al. 2014

BLL

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Abstract:Background: Novel treatment strategies are required to reduce the development of hepatic injury during surgical procedure in which renal ischemia/reperfusion (IR) is inevitable. Remote perconditioning (rPeC) has been proved to reduce the extent of kidney damages induced by renal IR injury. The aim of this study was to determine the protective effect of rPeC against hepatic injury caused by renal ischemia. Methods: Male rats were subjected to the right nephrectomy and randomized as: sham, no additional intervention; IR, 45 min of left renal pedicle occlusion; rPeC, four cycles of 5-min limb IR administered at the beginning of renal ischemia. After 24-h of reperfusion, the plasma and tissue samples were taken. Results: A signifi cant improvement in hepatic functional injury and oxidative damages were observed in the rPeC group compared to the IR group. However, histological evaluation and plasma levels of TNF-α revealed no signifi cant difference among groups. Conclusions: It is concluded that rPeC exerted protective effects on renal IR-induced hepatic injury as a remote organ. The protection may be a consequence of the reduction in oxidative stress in the liver. This simple approach may be a promising strategy against IR-induced remote organ damages in the clinical practice (Fig. 4

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Section: Discussionsupporting

confidence: 94%

“…It results in severe local and systemic injury, which contributes to an increased morbidity and mortality in these operations. Since multiorgan failure is a widespread consequence of severe renal injury, hepatic damage as a result of renal IR seems to be an extensive encountered problem (1).…”

mentioning

confidence: 99%

Hepatoprotective effects of remote perconditioning during renal ischemia

Sedaghat¹,

Kadkhodaee²,

Seifi³

et al. 2014

BLL

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“…They may not only induce mildly protective inflammation, but also cause excessive inflammation, which may lead to further tissue or organ damage. In the inflammatory response, when the organ or tissue is exposed to inflammation mediators 11,21,[31][32][33] the surface expression of the intercellular adhesion molecules on the polymorphonuclear leukocytes could be increased, what might activate these cells via β2 integrin-dependent mechanism. 30 Once the polymorphonuclear leukocytes are activated, they gather close to the liver vascular bed and further trigger the complement activation, as well as induce the activation of the platelet-activating factor.…”

Section: Discussionmentioning

confidence: 99%

Protective effects of sevoflurane in hepatic ischemia-reperfusion injury

Yuan

Zhao

et al. 2016

Int J Immunopathol Pharmacol

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The endothelial glycocalyx plays a critical role in the regulation of vascular structure and functions. Previous studies have demonstrated that sevoflurane, a volatile anesthetic, can preserve the endothelial glycocalyx in heart tissues against ischemia-reperfusion injury. However, little is known about the effects of sevoflurane pretreatment on the vascular structure and functions of liver tissues following ischemia-reperfusion injury. To this end, female Sprague-Dawley rats (n = 28) were anesthetized either with ketamine (80-120 mg/kg, i.p.) or with one minimum alveolar concentration (MAC) sevoflurane (2% v/v). Following in vivo hepatic ischemia procedure, the liver was isolated and reperfusion was produced. During the period of reperfusion, liver reperfusion samples were collected, and the concentrations of heparan sulfate and syndecan-1 (Syn-1), and the levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) enzymes, were measured. The morphology of hepatocytes and endothelial glycocalyx were then assessed by using the light and electron microscopies, respectively. Ischemia-reperfusion increased the release of HS and Syn-1, and elevated the levels of ALT and AST in a time-dependent manner. However, sevoflurane pretreatment reduced the release of HS and Syn-1and attenuated the levels of ALT and AST, in a time-dependent manner, as compared with ketamine pretreatment. Furthermore, sevoflurane pretreatment decreased the shedding of endothelial glycocalyx and hepatocytes necrosis. Sevoflurane pretreatment preserved the endothelial glycocalyx in the liver tissue against ischemia-reperfusion injury. The effect appears to help protect hepatocytes against ischemia-reperfusion-induced necrosis.

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“…Previous studies reported that renal IR could disturb liver function and morphology [9,10]. Kadkhodaee et al suggested that a minimum of 45 minutes ischemia period is necessary to produce the liver damage as a remote organ [10].…”

Section: Discussionmentioning

confidence: 99%

“…Kadkhodaee et al suggested that a minimum of 45 minutes ischemia period is necessary to produce the liver damage as a remote organ [10]. Wang et al showed that 1 hour ischemia and 4 or 8 hours reperfusion of the kidney increased the serum ALT and AST which seemed to be due to the hepatic cell membrane damage [9].…”

Section: Discussionmentioning

confidence: 99%

Effects of Aqueous Extract of Purslane (Portulaca oleracea) on Hepatic Enzymes in Two Models of Renal Ischemia-Reperfusion Injury in Rats

Askaripour

FatemiTabatabaei

Hosseini

et al. 2016

Zahedan J Res Med Sci

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Objectives: This study investigated the effect of purslane on hepatic enzymes following renal ischemia-reperfusion (IR) injury in rats by two methods. Materials and Methods:In this experimental study, 36 male Wistar rats randomly divided into 6 groups (n = 6): I) previously nephrectomized control, II) simultaneously nephrectomized control, III) previously nephrectomized + IR, IV) simultaneously nephrectomized + IR, V) previously nephrectomized treated by aqueous extract of P. oleracea L. + IR, VI) simultaneously nephrectomized treated by aqueous extract of P. oleracea L. + IR control and ischemia-reperfusion groups received vehicle and treatment groups received aqueous extract of purslane (300 mg/kg). In model 1, the right kidney was nephrectomized, 20 days prior to experiment, in model 2; nephrectomy was done just before induction of 45 minutes ischemia and 24 hours reperfusion to the left kidney. Results: Hepatic enzymes were elevated after induction of ischemia reperfusion. Administration of purslane decreased hepatic enzymes. Conclusions: Purslane prevented liver damage more effectively in simultaneously nephrectomized model.

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Liver Injury Following Renal Ischemia Reperfusion in Rats

Cited by 23 publications

References 8 publications

Hepatoprotective effects of remote perconditioning during renal ischemia

Hepatoprotective effects of remote perconditioning during renal ischemia

Protective effects of sevoflurane in hepatic ischemia-reperfusion injury

Effects of Aqueous Extract of Purslane (Portulaca oleracea) on Hepatic Enzymes in Two Models of Renal Ischemia-Reperfusion Injury in Rats

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