Liver iron overload and hepatic function in children with thalassemia major

Wahidiyat, Pustika Amalia; Iskandar, Stephen Diah; Rahmartani, Ludi Dhyani; Sekarsari, Damayanti

doi:10.14238/pi58.5.2018.233-7

Cited by 6 publications

(9 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The liver has the maximum capacity to store excess iron in the body, and various other organs, as well as the liver, are very susceptible to damage as a result of iron toxicity. In other studies, the correlation between serum ferritin and hepatic iron concentration has been reported in multiple blood-transfused thalassemia patients [7]. However, there is a paucity of data regarding the correlation between iron overload and liver damage in thalassemic patients.…”

Section: Introductionmentioning

confidence: 93%

Clinical and Biochemical Assessment of Liver Function Test and Its Correlation with Serum Ferritin Levels in Transfusion-dependent Thalassemia Patients

AlMoshary¹,

Imtiaz²,

Al-Mussaed³

et al. 2020

Cureus

View full text Add to dashboard Cite

The aim of our study was to correlate liver function tests with serum ferritin levels in multitransfused thalassemia patients. Methods This was a descriptive cross-sectional study conducted in the department of hematology, Khyber Medical University, from January 2018 to December 2018. Thalassemia patients of either sex dependent on transfusion ≥ 1 year and having a confirmatory report of the disease were included in our study. The nonprobability convenience sampling technique was used. The Pearson correlation coefficient was applied to observe the correlation between serum ferritin level and liver function tests. A p-value of ≤0.05 was considered statistically significant. SPSS version 23 (SPSS Inc., Chicago, Illinois) was used for data analysis. Results A total of 138 subjects of age range 2-23 years, with a mean age of 12.08 ± 6.02 years, were included in our study. The mean serum ferritin of patients in our study was 3278.64 ng/ml with the lowest of 285.2 ng/mL and the highest of 10940.2 ng/ml. With the increase in serum ferritin levels, a rapid increase in alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP) levels was seen. When serum ferritin levels were correlated with total bilirubin level, the bilirubin level remains static with a further increase in serum ferritin levels. Conclusion It was deduced that iron deposition is the ultimate reason for increased liver enzymes. There was a positive correlation between serum ferritin and ALT, AST, and ALP while a weak connection was found between serum ferritin and bilirubin levels.

show abstract

Section: Introductionmentioning

confidence: 93%

Clinical and Biochemical Assessment of Liver Function Test and Its Correlation with Serum Ferritin Levels in Transfusion-dependent Thalassemia Patients

AlMoshary¹,

Imtiaz²,

Al-Mussaed³

et al. 2020

Cureus

View full text Add to dashboard Cite

show abstract

“…(28,29) Liver iron overload in thalassemia major patients causes impairment on its function. (30,31) Theoretically, liver plays an important role in production, storage, and metabolism of lipid and lipoprotein in the body. One study finds that HDL-C and LDL-C levels are significantly affected by the severity of liver injury in non-alcoholic liver cirrhosis.…”

Section: Discussionmentioning

confidence: 99%

Glucose and Lipid Profiles in Adolescents with Thalassemia Major and Its Association with Iron Overload in Specific Organs

et al. 2019

Self Cite

View full text Add to dashboard Cite

BACKGROUND: Organ damage due to iron toxicity is one factor that increases the risk of getting cardiovascular and metabolic diseases in thalassemia patient. This study aims to determine glucose and lipid profiles in adolescents with thalassemia major and its association with iron overload in pancreas and liver.METHODS: This was a cross sectional study. Subjects were thalassemia major adolescents without any confounding factors that may affect glucose and lipid levels. Blood samples were collected to measure the glucose level, lipid profiles, ferritin level and transferrin saturation. T2-Magnetic Resonance Imaging was used to evaluate the iron overload in organs.RESULTS: From a total of 60 subjects, diabetes mellitus was diagnosed in 1 subject and impaired fasting glucose was diagnosed in 3 subjects. All subjects had high triglycerides/ high density lipoprotein-cholesterol (HDL-C) ratio, 59 subjects (98%) had low HDL-C, 18 subjects (30%) had hypertriglyceridemia, and none had abnormal high level of low density lipoprotein-cholesterol (LDL-C). The majority of subjects had ferritin ≥2,500 ng/mL (70%), mild pancreatic iron overload (56.6%), and moderate hepatic iron overload (43.8%). Degree of hyperferritinemia was not associated with glucose and lipid profiles. Blood glucose profiles were not associated with various degree of pancreatic iron overload. Similar result was also observed between lipid profiles and hepatic iron overload.CONCLUSION: Abnormal glucose and lipid profiles in thalassemia major can be found in adolescence. Normal blood glucose level isn’t necessarily associated with normal pancreatic iron deposition. Hepatic iron overload may worsen dyslipidemia in thalassemia major patients.KEYWORDS: glucose profile, lipid profile, pancreatic iron overload, hepatic iron overload, thalassemia major

show abstract

“…as the age progresses, either due to the cost of treatment., which is offset by the poor physical condition; of the patients, the reason may be the ,delayed of disease diagnosis to advanced. stages , when the treatment .may be not benefit with it, or the cause may be attributed; to the patient's poor health condition and suffering from severe complications of the disease .that may eventually lead to death (3) .…”

Section: -Thalassemia Relationship With Agementioning

confidence: 99%

“…marrow, which causes chronic anemia for children in the early stages of their. life as a result of receiving defective genes, one from the father ;and the other from the mother (3) . Thalassemia is often diagnosed; in the first six months of a newborn's life, and it may be fatal if the patient does not receive, appropriate treatment, Children with thalassemia need a blood transfusion, every 3-4 weeks, depending on the patient's age and the degree of.…”

Section: Introductionmentioning

confidence: 99%

Correlation Between Serum Ferritin And Liver Function in Thalassemia Patients

Zainab Qasim Muhammad Al-Yasiri

2020

Indian Journal of Forensic Medicine & Toxicology

View full text Add to dashboard Cite

Thalassemia ,is one of the most important hemolytic genetic, diseases that break down red blood cells, Children with thalassemia cannot produce. enough hemoglobin because; the bone marrow cannot produce enough red blood cells to meet their needs and the red blood cells produced ,by them are almost devoid of hemoglobin, and the disease is divided into alpha, and Beta thalassemia.The current study was designed with the aim of .investigating the relationship between serum ferritin and hepatic enzymes in thalassemia. patients, iron is stored primarily in the form of ,ferritin in liver cells. The study included 60 patients with thalassemia in; Dhi Qar governorate, distributed between. the two gender during the, research period, their ages ranged between (2 -26) years old, blood samples were taken in order to testing of. hemoglobin, ferritin, and liver enzymes (ATP, GOT, GPT) , and the same, tests were performed on healthy people 40 person ;as they are a control group.The results recorded; a high percentage of ,thalassemia incidence in males and a decrease in females. The study also showed; that the incidence of thalassemia reached its peak in the age. group (2-6) years and decreased with age, as it reached its lowest levels in the age, group (22-26) years.The study revealed .a significant decrease (0.05> P) in hemoglobin concentration in thalassemia, patients compared with the ;control group, and the results recorded a significant; increase (0.05 P <) in the concentration of ferritin in thalassemia, patients compared with the control group.The current study; also showed a significant increase (P <0.05) in GPT enzyme concentration in thalassemia. patients compared with the control group. There was a significant increase (P <0.05) of GOT enzyme; concentration in patients compared to the ,control group.The results indicated. that there was a significant increase (P <0.05) in the concentration of the ALP enzyme in the patients. compared with the control group.

show abstract

Liver iron overload and hepatic function in children with thalassemia major

Cited by 6 publications

References 11 publications

Clinical and Biochemical Assessment of Liver Function Test and Its Correlation with Serum Ferritin Levels in Transfusion-dependent Thalassemia Patients

Clinical and Biochemical Assessment of Liver Function Test and Its Correlation with Serum Ferritin Levels in Transfusion-dependent Thalassemia Patients

Glucose and Lipid Profiles in Adolescents with Thalassemia Major and Its Association with Iron Overload in Specific Organs

Correlation Between Serum Ferritin And Liver Function in Thalassemia Patients

Contact Info

Product

Resources

About