Liver Metastasis of Extremity Pleomorphic Liposarcoma Treated with Hepatic Resection

Vij, Mukul; Perumalla, Rajasekhar; Srivastava, Manoj; Rajalingam, Rajesh; Bharathan, Anand; Periasami, Saravanan; Rela, Mohamed

doi:10.1007/s12029-013-9539-x

Cited by 3 publications

(2 citation statements)

References 11 publications

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“…The liver is a rare site for PLPS metastases: to the best of our knowledge, only one such case has been described to date. 3 The present case was challenging because it might have been mistaken for other pleomorphic clear cell tumors. In fact, PLPS usually manifests as a painless mass located in the deep soft tissue and may go unnoticed until it reaches a significant size or metastasizes—as in the present case, in which the liver metastasis was the first evidence of neoplasm.…”

Section: Discussionmentioning

confidence: 87%

“…1 To the best of our knowledge, only one case of PLPS metastasizing to the liver has been reported to date. 3 Fine‐needle aspiration cytology (FNAC) is successfully used in the diagnosis of primary or metastatic soft tissue tumors including liposarcoma, 4 but liver metastases of PLPS diagnosed by FNAC have never been reported. The FNAC features of a PLPS with liver metastases as first clinical evidence are herein described.…”

Section: Introductionmentioning

confidence: 99%

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Pleomorphic liposarcoma with liver metastasis diagnosed by combined fine‐needle aspiration cytology and core‐needle biopsy

Ciliberti

Cretella

Zeppa

et al. 2021

Diagnostic Cytopathology

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Pleomorphic liposarcoma (PLPS) is the rarest liposarcoma subtype, with high-local recurrence and metastasis rates. Fine-needle aspiration cytology (FNAC) is successfully used in the diagnosis of primary or metastatic soft tissue tumors, but liver metastases of PLPS diagnosed by FNAC have never been reported. The cytological diagnosis depends on the identification of lipoblasts with sharply defined cytoplasmic vacuoles indenting and distorting the nucleus in the context of a pleomorphic tumor and in a proper clinical and imaging context. Despite its aggressive behavior, hematogenous liver metastases are rare, with just one case reported in literature. A case of PLPS liver metastasis and concomitant primary tumor diagnosed by FNAC and core needle biopsy is herein described.

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Section: Discussionmentioning

confidence: 87%

Section: Introductionmentioning

confidence: 99%

Pleomorphic liposarcoma with liver metastasis diagnosed by combined fine‐needle aspiration cytology and core‐needle biopsy

Ciliberti

Cretella

Zeppa

et al. 2021

Diagnostic Cytopathology

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Surgical Management of Metastatic Disease

Keung

Fairweather

Raut

2016

Surgical Clinics of North America

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Pleomorphic liposarcoma of the extremity with solitary huge liver metastasis at initial diagnosis treated with conversion surgery combined with adjuvant chemotherapy: a case report

Shimomura,

Shirai,

Terauchi

et al. 2023

J Med Case Reports

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Background Pleomorphic liposarcoma is the rarest subtype of liposarcoma. Pleomorphic liposarcomas are generally unresponsive to chemotherapy and radiotherapy. Moreover, metastasis in the liver, as the first and sole site, from a primary extremity soft tissue sarcoma, including pleomorphic liposarcoma, is extremely rare. Information regarding the appropriate management of these lesions is limited. Case presentation A 50-year-old Japanese woman presented with a mass in the left thigh. Imaging examination revealed a soft tissue sarcoma on the left posterior thigh. The tumor was histologically diagnosed as pleomorphic liposarcoma. Computed tomography examination for assessment of metastases incidentally detected a huge liver mass. Wide excision of sarcoma was performed prior to chemotherapy. Right trisectionectomy was necessary to achieve hepatic clearance; however, the future liver remnant volume was insufficient. Therefore, we decided to administer anthracycline-based chemotheraphy to shrink the tumor. After seven courses of adriamycin-based chemotherapy, the liver tumor size was reduced from 211 mm × 106 mm × 180 mm to 105 mm × 66 mm × 90 mm. Finally, a right hemihepatectomy was performed. The patient was continuously monitored and was metastasis or local recurrence free within 5 months after liver surgery. Conclusion Chemotherapy is effective in some cases for the treatment of unresectable liver metastases of pleomorphic liposarcoma, and complete resection is possible with conversion surgery. If the patient’s general condition permits, anthracycline-based chemotherapy can be used for the treatment of stage 4 pleomorphic liposarcoma.

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Liver Metastasis of Extremity Pleomorphic Liposarcoma Treated with Hepatic Resection

Cited by 3 publications

References 11 publications

Pleomorphic liposarcoma with liver metastasis diagnosed by combined fine‐needle aspiration cytology and core‐needle biopsy

Pleomorphic liposarcoma with liver metastasis diagnosed by combined fine‐needle aspiration cytology and core‐needle biopsy

Surgical Management of Metastatic Disease

Pleomorphic liposarcoma of the extremity with solitary huge liver metastasis at initial diagnosis treated with conversion surgery combined with adjuvant chemotherapy: a case report

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