Liver microsomal cytochrome P-450-dependent O-dealkylation reaction in various animals.

Matsubara, Takashi; Otsubo, Shigemi; Yoshihara, Emiko

doi:10.1254/jjp.33.1065

Cited by 21 publications

(8 citation statements)

References 23 publications

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“…CYP concentration was assessed according to Matsubara et al (1983). Ethoxyresorufin O-deethylation (EROD) was measured according to Pohl and Fouts (1980).…”

Section: Cytochrome P450 (Cyp) Dependent Monooxygenase Functionsmentioning

confidence: 99%

Efforts to establish an animal model of Fanconi syndrome after ifosfamide administration to rats

Appenroth

Werner

Lupp

et al. 2007

J of Applied Toxicology

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About 10% of children develop Fanconi syndrome (FS) a few months after ifosfamide (IFO) treatment. To establish an animal model, IFO was injected as 4 or 5 treatment courses (TCs, once daily for 3 consecutive days), to adult female rats (AF, 8 mg 100 g(-1) body wt, 4 TCs), to young female rats (YF, 8 mg 100 g(-1) body wt, 5 TCs) and to male rats (M, 6 mg 100 g(-1) body wt, 4 TCs). In the adult female rats, polyuria with electrolyte and albumin wasting occurred acutely, 2 days after the first treatment course. After the third treatment course, 30% of the rats died, but survivors showed a reduced excretion of electrolytes and glucose. The body weight increase was significantly diminished in adult female and male rats by about 25% or 70%, respectively. Up to 5 months after 5 TCs in young female rats, 15% of the animals died but the survivors did not show any sign of renal failure. In males, 28% of the rats died and in surviving animals the excretion of electrolytes, proteins and glucose as well as GFR were reduced 7 weeks after the last treatment course. There were no pathomorphological changes in kidney and liver. Determination of renal and hepatic cytochrome P450 activities indicated that results of adult female and male rats could be caused by starving, known as a common side effect of IFO, and not by its nephrotoxicity. Altogether, it was not possible to establish a model of a Fanconi syndrome persisting after cessation of IFO treatment in our rat strain, whereas acute, FS-like IFO effects on the kidney could be shown.

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“…CYP concentration was assessed according to Matsubara et al (1983). Ethoxyresorufin O-deethylation (EROD) was measured according to Pohl and Fouts (1980).…”

Section: Cytochrome P450 (Cyp) Dependent Monooxygenase Functionsmentioning

confidence: 99%

Efforts to establish an animal model of Fanconi syndrome after ifosfamide administration to rats

Appenroth

Werner

Lupp

et al. 2007

J of Applied Toxicology

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“…On the other hand, treatment of channel catfish with 3-MC produced marked increases in EROD, but also in BROD and PROD activities (Ankley et al, 1987), which is more similar to our results in view of the high rate of induction of BROD activity in carp microsomes. Hepatic alkoxycoumarins activities were also demonstrated to be differentially induced in rodent species: phenobarbital increased all activities, while 3-MC and P-NF did not increase MCOD activity, but strongly enhanced the other activities (Kamataki et al, 1980;Matsubara et al, 1983). In sharp contrast with this situation, the rate of induction in carp liver was in inverse ratio to the length of the alkyl chain of the substrate, i.e., MCOD was the most induced activity.…”

Section: Resultsmentioning

confidence: 95%

Effect of β-naphthoflavone and MCPA on liver and kidney drug-metabolizing enzymes from the carp, Cyprinus carpio

Rivière

Devaux

Gonin

et al. 1990

Ecotoxicology and Environmental Safety

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The effects of fl-naphthoflavone (B-NF) and a chlorophenoxyacetic acid herbicide (MCPA) on hepatic and renal monooxygenase activities and conjugating enzymes from immature carp (Cyprinus carpio) were studied. j3-NF increased hepatic monooxygenase activities but the patterns of differential induction generally obtained in rat liver microsomes with two series of homologous substrates, alkoxycoumarins and alkylresomfins, were not found to be similar in carp liver microsomes. On the other hand, MCPA caused no changes in oxidative metabolism, with the exception of decreased aryl hydrocarbon hydroxylase activity. Renal activities were not modified by MCPA, while b-NF treatment resulted in marked increases in monooxygenase activities with alkylresorufins as substrates. No changes were found in conjugation activities after treatment with MCPA or P-NF. These results indicate that (a) the herbicide MCPA should have no effect on drug-metabolizing enzymes from carp, and (b) the hepatic and renal monooxygenase activities of carp are responsive to fl-NF, allowing their use in monitoring water pollution.

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“…The liver microsomes from intact male rats and DEX‐treated female rats were prepared according to the method of Matsubara et al . . Pooled human liver microsomes were purchased from Xeno Tech LLC (Lenexa, KS, USA).…”

Section: Methodsmentioning

confidence: 99%

Investigation of drug–drug interaction via mechanism‐based inhibition of cytochrome P450 3A by macrolides in dexamethasone‐treated female rats

Kanazu

Satô

Kadono

et al. 2012

Biopharm & Drug Disp

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The in vitro and in vivo inhibition of cytochrome P450 (CYP) 3A with mechanism‐based inhibition (MBI) by macrolides was investigated using dexamethasone‐treated female rats (DEX‐female rats). In the in vitro CYP inhibition studies using erythromycin (ERM) and clarithromycin (CAM), similar inhibition responses were observed between human and DEX‐female rat liver microsomes, however, there were fewer effects in intact male rats. The ex vivo study showed that midazolam (MDZ) metabolism in liver microsomes of DEX‐female rats was reduced by ERM administration and the inhibitory effect was increased with increasing ERM doses, indicating that metabolite intermediate complex formation caused irreversible inhibition of CYP3A activity in DEX‐female rats as well as in humans. In the in vivo studies, ERM and CAM significantly increased the area under the plasma concentration–time curve of MDZ and decreased the total clearance in DEX‐female rats. It was concluded that the DDIs via MBI of CYP3A following macrolide administration in humans could be reproduced in female rats, suggesting that DEX‐female rats can serve as an in vivo model for assessing this DDI in humans. Copyright © 2012 John Wiley & Sons, Ltd.

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Liver microsomal cytochrome P-450-dependent O-dealkylation reaction in various animals.

Cited by 21 publications

References 23 publications

Efforts to establish an animal model of Fanconi syndrome after ifosfamide administration to rats

Efforts to establish an animal model of Fanconi syndrome after ifosfamide administration to rats

Effect of β-naphthoflavone and MCPA on liver and kidney drug-metabolizing enzymes from the carp, Cyprinus carpio

Investigation of drug–drug interaction via mechanism‐based inhibition of cytochrome P450 3A by macrolides in dexamethasone‐treated female rats

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