“…Due to the lack of a fully developed immune system in the chick embryo 3 , 5 , the CAM is suitable for tumor engraftment to study various aspects of the angiogenic and metastatic potential of human malignancies 3 , 4 , such as glioma 6 - 8 , colorectal cancer 9 , 10 , leukemia 11 , ovarian cancer 4 , prostate cancer 12 , 13 , and osteosarcoma 14 . In addition, the CAM has been used to test the biocompatibility of organic and inorganic materials 15 - 17 , the ability of bacterial strains to invade epithelial barriers 18 , vascular anomalies and Moyamoya Disease 19 - 24 , the organogenetic capacity of xenograft or homograft 25 , 26 , the mechanisms of wound healing 27 , 28 , and the differentiation of the blood-brain barrier 29 , 30 . The aim of the present review is to summarize the application of the CAM in the field of neurosurgery research.…”