Liver-targeted Nano-MitoPBN normalizes glucose metabolism by improving mitochondrial redox balance

Wu, Meiling; Liao, Lihao; Jiang, Lu; Zhang, Chunwang; Gao, Hongyang; Qiao, Liang; Liu, Shanlin; Shi, Dongyun

doi:10.1016/j.biomaterials.2019.119457

Cited by 41 publications

(37 citation statements)

References 44 publications

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“…The application of NPs for radioprotection has been discussed in [242,243] where key classes of nanomaterial radioprotectors are listed. These include encapsulated molecular radioprotectors such as flavonoids [244] or other compounds formulated in liposomes, [245] polysaccharides, [246] fullerenes, carbon NPs of various types [247,248] some of which are clinically approved as well as inorganic ceria (CeO 2 ). [249] The latter represents a catalytic system with interesting enzyme-mimetic properties able to reduce oxidative and also nitrosative stress [186] mostly related to the of the Ce 3+ /Ce 4+ valence ratio on the NP surface.…”

Section: Free Radical Scavenging By Nanoparticlesmentioning

confidence: 99%

Mechanisms for Tuning Engineered Nanomaterials to Enhance Radiation Therapy of Cancer

et al. 2020

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Engineered nanomaterials that produce reactive oxygen species on exposure to X‐ and gamma‐rays used in radiation therapy offer promise of novel cancer treatment strategies. Similar to photodynamic therapy but suitable for large and deep tumors, this new approach where nanomaterials acting as sensitizing agents are combined with clinical radiation can be effective at well‐tolerated low radiation doses. Suitably engineered nanomaterials can enhance cancer radiotherapy by increasing the tumor selectivity and decreasing side effects. Additionally, the nanomaterial platform offers therapeutically valuable functionalities, including molecular targeting, drug/gene delivery, and adaptive responses to trigger drug release. The potential of such nanomaterials to be combined with radiotherapy is widely recognized. In order for further breakthroughs to be made, and to facilitate clinical translation, the applicable principles and fundamentals should be articulated. This review focuses on mechanisms underpinning rational nanomaterial design to enhance radiation therapy, the understanding of which will enable novel ways to optimize its therapeutic efficacy. A roadmap for designing nanomaterials with optimized anticancer performance is also shown and the potential clinical significance and future translation are discussed.

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Section: Free Radical Scavenging By Nanoparticlesmentioning

confidence: 99%

Mechanisms for Tuning Engineered Nanomaterials to Enhance Radiation Therapy of Cancer

et al. 2020

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“…Brenza et al reported that MitoQ was encapsulated in brain targeting nanoparticles composed of poly (lactic-co-glycolic acid) (PLGA) [Mito-Apo] and these particles accumulated in the brain [81]. Wu et al reported that a TPP-modified free radical scavenger was encapsulated in liver targeting lipid nanoparticles [MitoPBN], after which, the anti-oxidant therapeutic effect was examined using a diabetes model animal [82]. In this study, MitoPBN achieved successful liver targeting and increased mitochondrial maximal respiration, resulting in an increase in glycolysis by 30%.…”

Section: Mitochondria-targeted Delivery Of Antioxidants Using the Tppmentioning

confidence: 99%

Therapeutic Strategies for Regulating Mitochondrial Oxidative Stress

et al. 2020

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There have been many reports on the relationship between mitochondrial oxidative stress and various types of diseases. This review covers mitochondrial targeting photodynamic therapy and photothermal therapy as a therapeutic strategy for inducing mitochondrial oxidative stress. We also discuss other mitochondrial targeting phototherapeutic methods. In addition, we discuss anti-oxidant therapy by a mitochondrial drug delivery system (DDS) as a therapeutic strategy for suppressing oxidative stress. We also describe cell therapy for reducing oxidative stress in mitochondria. Finally, we discuss the possibilities and problems associated with clinical applications of mitochondrial DDS to regulate mitochondrial oxidative stress.Biomolecules 2020, 10, 83 2 of 23 Parkinson's and Alzheimer's diseases, by the direct neutralization of ROS and by suppressing inflammation [5,6]. Furthermore, CoQ 10 , a potent ubiquinone antioxidant, has been reported to show significant protective effects on mitochondria of the pancreatic beta cells during the oxidative stress induced by the chronic use of tacrolimus [7]. Due to the highly hydrophobic characteristics and the fact that most of the antioxidant molecules accumulate in a nonspecific manner, a high dose is needed to obtain the desired effects. Thus, the selective delivery of this compound would be expected to further strengthen its effectivity.In the context of cancer therapy, mitochondrial ROS were found to play an important role as a signaling molecule in controlling cell proliferation by virtue of its ability to regulate the mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK) signaling pathway [8]. Moreover, antioxidant activity, such as GSH and thioredoxin, was also reported to be essential for the initiation of and the progression of cancer. Inhibition of the antioxidant activity resulted in a significant reduction in tumor progression and metastasis [9][10][11]. These findings suggest that cancer cells are maintained under conditions of ROS stress and that antioxidant supplementation may be irrelevant for cancer therapy [12][13][14]. However, ROS interact with several major biologically active molecules such as proteins, lipids, and nucleic acids, leading to irreversible oxidative damage and the further induction of lethal effects for the cells. Therefore, promoting ROS production could be a promising strategy for treating tumors. There are numerous methods that can be employed to promote ROS levels in cancers, i.e., depleting or inhibiting antioxidant activity [15,16] and inhibiting the mitochondrial respiratory system [17], and producing an excessive amount of ROS through photochemical reactions. The latter effort shows a high selectivity for tumor cells, making it more encouraging in contrast to other efforts.This review focuses on therapeutic strategies for regulating mitochondrial oxidative stress. The main theme includes therapeutic strategies designed to induce oxidative stress and suppress mitochondrial oxidative stress (Figure 1). As ...

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“…Polymeric nanomedicines open a promising option for the management of diabetes [ 180 ]. Aimed at the high cellular oxidative stress during diabetes, administrating antioxidants to regulate the redox balance have proven to be an effective approach [ 181 ]. Thus, we suppose that delivering H 2 S by means of polymeric carriers is worth exploring for alleviating diabetes and its complications.…”

Section: Therapeutic Applications Of Intelligent Polymeric H ...mentioning

confidence: 99%

Intelligent polymeric hydrogen sulfide delivery systems for therapeutic applications

Rong

Wang

Zhou

et al. 2023

Bioactive Materials

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Liver-targeted Nano-MitoPBN normalizes glucose metabolism by improving mitochondrial redox balance

Cited by 41 publications

References 44 publications

Mechanisms for Tuning Engineered Nanomaterials to Enhance Radiation Therapy of Cancer

Mechanisms for Tuning Engineered Nanomaterials to Enhance Radiation Therapy of Cancer

Therapeutic Strategies for Regulating Mitochondrial Oxidative Stress

Intelligent polymeric hydrogen sulfide delivery systems for therapeutic applications

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