Liver Transplantation for Hepatic Adenoma: A UNOS Database Analysis and Systematic Review of the Literature

Ziogas, Ioannis A.; Tasoudis, Panagiotis; Serifis, Nikolaos; Alexopoulos, Sophoclis P.; Montenovo, Martin I.; Shingina, Alexandra

doi:10.1097/txd.0000000000001264

Cited by 8 publications

(6 citation statements)

References 88 publications

(161 reference statements)

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“…Patients meeting this highly select criteria may be offered a priority score for transplantation. The overall outcome for these patients is similar to other indications for liver transplantation; however, the strict selection criteria are essential, given the overall indolent disease course and discordance between imaging concerns and explant findings of malignancy (94).…”

Section: Solid Liver Lesionsmentioning

confidence: 94%

ACG Clinical Guideline: Focal Liver Lesions

Frenette,

Mendiratta-Lala,

Salgia

et al. 2024

Am J Gastroenterol

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Focal liver lesions (FLLs) have become an increasingly common finding on abdominal imaging, especially asymptomatic and incidental liver lesions. Gastroenterologists and hepatologists often see these patients in consultation and make recommendations for management of multiple types of liver lesions, including hepatocellular adenoma, focal nodular hyperplasia, hemangioma, and hepatic cystic lesions including polycystic liver disease. Malignancy is important to consider in the differential diagnosis of FLLs, and healthcare providers must be familiar with the diagnosis and management of FLLs. This American College of Gastroenterology practice guideline uses the best evidence available to make diagnosis and management recommendations for the most common FLLs.

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Section: Solid Liver Lesionsmentioning

confidence: 94%

ACG Clinical Guideline: Focal Liver Lesions

Frenette,

Mendiratta-Lala,

Salgia

et al. 2024

Am J Gastroenterol

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“…Hepatocellular adenoma (HCA) It is very rare to perform LT for HCAs. According to the UNOS database (1987-2020), a total of 142 patients with HCA had undergone LT [161].…”

Section: Hepatic Hemangiomamentioning

confidence: 99%

Asian Pacific Association for the Study of the Liver clinical practice guidelines on liver transplantation

Kim,

Yoon,

Kim

et al. 2024

Hepatol Int

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Liver transplantation is a highly complex and challenging field of clinical practice. Although it was originally developed in western countries, it has been further advanced in Asian countries through the use of living donor liver transplantation. This method of transplantation is the only available option in many countries in the Asia-Pacific region due to the lack of deceased organ donation. As a result of this clinical situation, there is a growing need for guidelines that are specific to the Asia-Pacific region. These guidelines provide comprehensive recommendations for evidence-based management throughout the entire process of liver transplantation, covering both deceased and living donor liver transplantation. In addition, the development of these guidelines has been a collaborative effort between medical professionals from various countries in the region. This has allowed for the inclusion of diverse perspectives and experiences, leading to a more comprehensive and effective set of guidelines. Keywords Living donor liver transplantation • Deceased donor liver transplantation • Multidisciplinary • GradeSpecial consideration: LDLT in ACLF In a study of 112 LDLT recipients with ACLF, defined by the APASL definition, post-LT outcomes were excellent (92.9% at 5 years) [69]. In a study on high-model end-stage liver disease (MELD) (score ≥ 30) LDLT recipients with ACLF (n = 190), defined by the World Congress of Gastroenterology [70], the 5-year survival rate was 72.1% [71]. In a study of 117 LDLT recipients who had ACLF, as defined by the EASL-CLIF definition, post-transplant survival after LDLT was 92.9%, 85.4%, and 75.6% at 1 year, while mortality rate without LT was 28.5%, 77.7%, and 93.4% at 90 days, for ACLF grades 1, 2, and 3, respectively [72]. These data indicate that LDLT can be a life-saving treatment option for patients with ACLF.LDLT differs significantly from DDLT, as the timing of LDLT can be determined by the transplant team. There are advantages and disadvantages of LDLT in the setting of ACLF. The benefit of LDLT in patients with ACLF is its ability to provide rapid transplantation to critically ill patients [73], without waiting for deceased donor allocation. The ideal time for LT can be selected by transplant team when willing living donor is available. If ideal time for LT can be selected in the dynamic course of ACLF, this may improve post-LT outcome. The disadvantages of LDLT include the need for healthy, willing liver donor, and the use of partial grafts for critically ill patients. A graft-to-recipient weight ratio (GRWR) is a factor associated with post-LT outcomes in LDLT [74]. The donor risk index is a factor associated with post-LT outcomes for patients with ACLF who received DDLT [66,75]. This indicates that DDLT, which uses whole liver grafts, might be a better compared to LDLT, which uses partial grafts, in ACLF. In addition, there are uncertainties regarding the criteria for living donor graft quality that is required for critically ill patients with ACLF. In studies that reported...

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“…Consistent with the higher HCA prevalence in women, nearly 80% of waitlisted or transplanted patients with HCAs are female, although male sex is associated with worse post-transplant outcomes. 137 …”

Section: Fibrotic Diseasesmentioning

confidence: 99%

Sex differences in chronic liver disease and benign liver lesions

Cooper,

Delk,

Devuni

et al. 2023

JHEP Reports

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Liver Transplantation for Hepatic Adenoma: A UNOS Database Analysis and Systematic Review of the Literature

Abstract: Supplemental Digital Content is available in the text.

Cited by 8 publications

References 88 publications

ACG Clinical Guideline: Focal Liver Lesions

ACG Clinical Guideline: Focal Liver Lesions

Asian Pacific Association for the Study of the Liver clinical practice guidelines on liver transplantation

Sex differences in chronic liver disease and benign liver lesions

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