Liver Tumor Gross Margin Identification and Ablation Monitoring during Liver Radiofrequency Treatment

Hsu, Christopher P.; Razavi, Mahmood K.; So, Samuel; Parachikov, Ilian H.; Benaron, David A.

doi:10.1097/01.rvi.000017833.30967.39

Cited by 28 publications

(27 citation statements)

References 16 publications

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“…3 suggest that the optical properties of tissue types contain the most discriminative information for tissue classification in the VIS wavelength range between 450 nm and 750 nm. These findings are similar to those that have been reported for different ex vivo studies on human liver tissue of tumor patients with primary cancer [14], as well as with liver metastases [17][18][19].…”

Section: Discussionsupporting

confidence: 80%

“…Spectroscopic detection of malignant tumors in liver specimens has been successfully performed for primary liver cancer [14] and liver metastases in humans [15][16][17][18][19] as well as in animal models [20,21]. In a clinical ex vivo study by Evers et al [17] liver specimen of 24 patients who underwent surgery for colorectal liver metastases were analyzed with DRS in the visible (VIS) and near infrared (NIR) spectral range.…”

Section: Introductionmentioning

confidence: 99%

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Diffuse reflectance spectroscopy of human liver tumor specimens - towards a tissue differentiating optical biopsy needle using light emitting diodes

Keller¹,

Białecki²,

Wilhelm³

et al. 2018

Biomed. Opt. Express

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Significant numbers of liver biopsies fail to yield representative tissue samples. This study was conducted to evaluate the ability of LED-based diffuse reflectance spectroscopy to discriminate tumors from liver parenchyma. Ex vivo spectra were acquired from malignant lesions and liver parenchyma of 32 patients who underwent liver resection using a white light source and several LEDs. Integrated spectra of two combined LEDs with emission peaks at 470 nm and 515 nm were classified with 98.4% sensitivity and 99.2% specificity. The promising results could yield to a simple handheld and cost-efficient tool for real-time tissue differentiation implemented in a biopsy needle. H. Hendriks, J. Wesseling, and T. J. Ruers, "Improved identification of peripheral lung tumors by using diffuse reflectance and fluorescence spectroscopy," Lung Cancer 80(2), 165-171 (2013). 1929-1939 (2002). 194-203 (1998).

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Section: Discussionsupporting

confidence: 80%

Section: Introductionmentioning

confidence: 99%

Diffuse reflectance spectroscopy of human liver tumor specimens - towards a tissue differentiating optical biopsy needle using light emitting diodes

Keller¹,

Białecki²,

Wilhelm³

et al. 2018

Biomed. Opt. Express

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“…Similar results were achieved by Hsu et al, who performed spectral measurements on both animal and human liver tissue. 29 The time course of spectral changes observed in Anderson are consistent with the three characteristic stages of ablation observed in the present study.…”

Section: Discussionsupporting

confidence: 78%

Monitoring of tumor radio frequency ablation using derivative spectroscopy

et al. 2014

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Abstract. Despite the widespread use of radio frequency (RF) ablation, an effective way to assess thermal tissue damage during and after the procedure is still lacking. We present a method for monitoring RF ablation efficacy based on thermally induced methemoglobin as a marker for full tissue ablation. Diffuse reflectance (DR) spectra were measured from human blood samples during gradual heating of the samples from 37 to 60, 70, and 85°C. Additionally, reflectance spectra were recorded real-time during RF ablation of human liver tissue ex vivo and in vivo. Specific spectral characteristics of methemoglobin were extracted from the spectral slopes using a custom optical ablation ratio. Thermal coagulation of blood caused significant changes in the spectral slopes, which is thought to be caused by the formation of methemoglobin. The time course of these changes was clearly dependent on the heating temperature. RF ablation of liver tissue essentially led to similar spectral alterations. In vivo DR measurements confirmed that the method could be used to assess the degree of thermal damage during RF ablation and long after the tissue cooled.

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“…Recently, we described an optical needle probe able to perform optical measurements in tumor tissue [21], [28], [29]. Optical measurements conducted through very fine needles (smaller than 27 G) open the potential to assess treatment response of (solid) tumors at deep-tissue sites [30]. The aim of this study was to investigate whether dual-modality DRS-AFS, incorporated in a small needle probe, was able to monitor the dynamics of tumor response after treatment with cisplatin using a preclinical mouse model for BRCA1-mutated breast cancer.…”

Section: Introductionmentioning

confidence: 99%

Monitoring of Tumor Response to Cisplatin Using Optical Spectroscopy

Spliethoff¹,

Evers²,

Jaspers³

et al. 2014

Translational Oncology

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INTRODUCTION: Anatomic imaging alone is often inadequate for tuning systemic treatment for individual tumor response. Optically based techniques could potentially contribute to fast and objective response monitoring in personalized cancer therapy. In the present study, we evaluated the feasibility of dual-modality diffuse reflectance spectroscopy–autofluorescence spectroscopy (DRS-AFS) to monitor the effects of systemic treatment in a mouse model for hereditary breast cancer. METHODS: Brca1−/−; p53−/− mammary tumors were grown in 36 mice, half of which were treated with a single dose of cisplatin. Changes in the tumor physiology and morphology were measured for a period of 1 week using dual-modality DRS-AFS. Liver and muscle tissues were also measured to distinguish tumor-specific alterations from systemic changes. Model-based analyses were used to derive different optical parameters like the scattering and absorption coefficients, as well as sources of intrinsic fluorescence. Histopathologic analysis was performed for cross-validation with trends in optically based parameters. RESULTS: Treated tumors showed a significant decrease in Mie-scattering slope and Mie-to-total scattering fraction and an increase in both fat volume fraction and tissue oxygenation after 2 days of follow-up. Additionally, significant tumor-specific changes in the fluorescence spectra were seen. These longitudinal trends were consistent with changes observed in the histopathologic analysis, such as vital tumor content and formation of fibrosis. CONCLUSIONS: This study demonstrates that dual-modality DRS-AFS provides quantitative functional information that corresponds well with the degree of pathologic response. DRS-AFS, in conjunction with other imaging modalities, could be used to optimize systemic cancer treatment on the basis of early individual tumor response.

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Liver Tumor Gross Margin Identification and Ablation Monitoring during Liver Radiofrequency Treatment

Cited by 28 publications

References 16 publications

Diffuse reflectance spectroscopy of human liver tumor specimens - towards a tissue differentiating optical biopsy needle using light emitting diodes

Diffuse reflectance spectroscopy of human liver tumor specimens - towards a tissue differentiating optical biopsy needle using light emitting diodes

Monitoring of tumor radio frequency ablation using derivative spectroscopy

Monitoring of Tumor Response to Cisplatin Using Optical Spectroscopy

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