Living Cells and Cell-Derived Vesicles: A Trojan Horse Technique for Brain Delivery

Ou, Ante; Wang, Yuewei; Zhang, Jiaxin; Huang, Yongzhuo

doi:10.3390/pharmaceutics15041257

Cited by 6 publications

(3 citation statements)

References 155 publications

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“…Here, nanoparticles enter the bloodstream first and then navigate through the selective BBB, with engineered nanoparticles potentially accessing the brain. Cells themselves may carry nanomaterials through the BBB, becoming an important traffic route to the CNS for being considered (Ou et al, 2023). Nanoparticles can travel along nerve fibers, like the olfactory nerve, reaching deeper brain regions post-exposure.…”

Section: B Lood-b R Ain Barriermentioning

confidence: 99%

Implications of environmental nanoparticles on neurodegeneration

Hermosillo‐Abundis,

Méndez‐Rojas,

Arias‐Carrión

2024

J of Neuroscience Research

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The ubiquity of nanoparticles, sourced from both natural environments and human activities, presents critical challenges for public health. While offering significant potential for innovative biomedical applications—especially in enhancing drug transport across the blood–brain barrier—these particles also introduce possible hazards due to inadvertent exposure. This concise review explores the paradoxical nature of nanoparticles, emphasizing their promising applications in healthcare juxtaposed with their potential neurotoxic consequences. Through a detailed examination, we delineate the pathways through which nanoparticles can reach the brain and the subsequent health implications. There is growing evidence of a disturbing association between nanoparticle exposure and the onset of neurodegenerative conditions, highlighting the imperative for comprehensive research and strategic interventions. Gaining a deep understanding of these mechanisms and enacting protective policies are crucial steps toward reducing the health threats of nanoparticles, thereby maximizing their therapeutic advantages.

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Section: B Lood-b R Ain Barriermentioning

confidence: 99%

Implications of environmental nanoparticles on neurodegeneration

Hermosillo‐Abundis,

Méndez‐Rojas,

Arias‐Carrión

2024

J of Neuroscience Research

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“…Various kinds of cells showed diverse dose–response curves for the cell viability after the exposure of CIONPs. Majeed and Ou et al [ 25 , 26 ] observed in guinea pigs that CIONPs induce respiratory problems. Hadrup and Ansari et al [ 27 , 28 ] reported that CIONPs cause micronuclei to develop in human peripheral lymphocytes.…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, this study investigated the biocompatibility of CIONPs and their adverse effects on different organs, such as the kidneys, liver, spleen, heart, and brain of rabbits ( Oryctolagus cuniculus ). The CIONPs were injected into the rabbits following the previous experimental protocol [ 19 , 26 ] for hematological, serum biochemical, and histopathology of selected organs of the controlled and treated rabbits.…”

Section: Introductionmentioning

confidence: 99%

Cobalt Iron Oxide (CoFe2O4) Nanoparticles Induced Toxicity in Rabbits

Khan

Buzdar

Hussain

et al. 2023

Veterinary Sciences

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The market for nanoparticles has grown significantly over the past few decades due to a number of unique qualities, including antibacterial capabilities. It is still unclear how nanoparticle toxicity works. In order to ascertain the toxicity of synthetic cobalt iron oxide (CoFe2O4) nanoparticles (CIONPs) in rabbits, this study was carried out. Sixteen rabbits in total were purchased from the neighborhood market and divided into two groups (A and B), each of which contained eight rabbits. The CIONPs were synthesized by the co-precipitation method. Crystallinity and phase identification were confirmed by X-ray diffraction (XRD). The average size of the nanoparticles (13.2 nm) was calculated by Scherrer formula (Dhkl = 0.9 λ/β cos θ) and confirmed by TEM images. The saturation magnetization, 50.1 emug−1, was measured by vibrating sample magnetometer (VSM). CIONPs were investigated as contrast agents (CA) for magnetic resonance images (MRI). The relaxivity (r = 1/T) of the MRI was also investigated at a field strength of 0.35 T (Tesla), and the ratio r2/r1 for the CIONPs contrast agent was 6.63. The CIONPs were administrated intravenously into the rabbits through the ear vein. Blood was collected at days 5 and 10 post-exposure for hematological and serum biochemistry analyses. The intensities of the signal experienced by CA with CIONPs were 1427 for the liver and 1702 for the spleen. The treated group showed significantly lower hematological parameters, but significantly higher total white blood cell counts and neutrophils. The results of the serum biochemistry analyses showed significantly higher and lower quantities of different serum biochemical parameters in the treated rabbits at day 10 of the trial. At the microscopic level, different histological ailments were observed in the visceral organs of treated rabbits, including the liver, kidneys, spleen, heart, and brain. In conclusion, the results revealed that cobalt iron oxide (CoFe2O4) nanoparticles induced toxicity via alterations in multiple tissues of rabbits.

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