Living donor liver transplantation for fulminant hepatic failure

Matsui, Yucihi; Sugawara, Yasuhiko; Yamashiki, Noriyo; Kaneko, Junichi; Tamura, Sumihito; Togashi, Junichi; Makuuchi, Masatoshi; Kokudo, Norihiro

doi:10.1111/j.1872-034x.2008.00372.x

Cited by 24 publications

(37 citation statements)

References 51 publications

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“…Recently, liver transplantation has become a remarkably effective life-saving treatment for patients with fulminant hepatic failure and end-stage chronic liver disease [1][2][3][4][5] . Increases in both the number of liver transplantation procedures and the indications for the procedure have resulted in a chronic worldwide shortage of organs for transplantation.…”

Section: Discussionmentioning

confidence: 99%

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Development of a New Bioartificial Liver Support System Using a Radial-flow Bioreactor

Aoki

Murakami

Yasuda³

et al. 2015

Showa Univ J Med Sci

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: There is an increasing number of patients with severe liver disease that requires whole organ transplantation or living-related split liver transplantation. This has resulted in a shortage of donor organs, which is particularly problematic and still awaits resolution. Bioarti cial liver BAL support systems have been developed with the aim of supporting patients with life-threatening liver disease until their liver recovers. Here, we describe a high performance three-dimensional rat hepa tocyte culture system using a radial-ow bioreactor RFB with a polyvinyl alcohol PVA membrane as a small-scale BAL support system. Hepatocytes from male Sprague-Dawley rat livers were isolated and divided into two groups as follows. Group A : isolated hepatocytes were maintained in culture medium as controls ; and group B : isolated hepatocytes were injected into the medium cham ber of the RFB-PVA culture system. Sampling was carried out every 48 h to ana lyze the concentrations of ammonia and albumin in the medium. Light and elec tron microscopic examination of hepatocytes explanted from the PVA membrane was also performed. Albumin production and urea synthesis by cells in group B were both signi cantly higher than in group A. Hematoxylin-Eosin staining of the cells in group B showed that three-dimensional cell masses were attached to the PVA membrane. It also showed that the cells were stably proliferating in the porous spaces of the PVA. Scanning electron microscopic images of group B also showed clusters of hepatocytes attached to the PVA membrane. Hepatocyte clus ters growing in the RFB-PVA culture system retained their biological function and were stable in the porous spaces of the PVA membrane. This cell culture system may be useful for the development of new BAL support systems.

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Section: Discussionmentioning

confidence: 99%

“…These strategies aim to support patients with borderline functional liver cell mass either until an appropriate transplantable organ becomes available or until the liver recovers from injury [1][2][3][4][5][6][7][8] .…”

Section: Introductionmentioning

confidence: 99%

Development of a New Bioartificial Liver Support System Using a Radial-flow Bioreactor

Aoki

Murakami

Yasuda³

et al. 2015

Showa Univ J Med Sci

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show abstract

“…On the other hand, in Asian countries, the donation from deceased donors is severely limited because of various cultural and social reasons [16]. Approximately 50% of patients listed for emergency liver transplantation have died while awaiting a graft because of the lack of a timely suitable donor [17,18]. So, in order to rescue more patients in a setting of the shortage of liver grafts, prognostic factors useful to determine the suitable timing for liver transplantation are required.…”

Section: Discussionmentioning

confidence: 99%

Serum Levels of Soluble Adhesion Molecules as Prognostic Factors for Acute Liver Failure

et al. 2012

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Background/Aims: In patients with septic shock, the degree of liver dysfunction is correlated with serum levels of soluble intercellular adhesion molecule (sICAM)-1. We aimed to assess the usefulness of serum levels of soluble adhesion molecules as prognostic factors for acute liver failure (ALF). Methods: Serum levels of soluble platelet endothelial cell adhesion molecule (sPECAM)-1, sICAM-3, soluble endothelial (sE) selectin, sICAM-1, soluble platelet selectin, and soluble vascular cell adhesion molecule-1 on admission were measured in 37 ALF patients and 34 healthy controls. Results: Twenty-two ALF patients (59%) reached to fatal outcomes. Serum levels of sPECAM-1, sICAM-3, sE-selectin and sICAM-1 were higher in ALF patients than healthy controls. In 37 ALF patients, by the multivariate logistic regression analysis, ratio of direct to total bilirubin (per 0.1 increase; OR 0.11, 95% CI 0.01–0.99), serum sPECAM-1 level (per 100 ng/ml increase; OR 4.37, 95% CI 1.23–15.5) and serum sICAM-1 level (per 100 ng/ml increase; OR 0.49, 95% CI 0.27–0.89) were associated with fatal outcomes. Using receiver operating characteristics curve, each area under the curve of serum sPECAM-1 and sICMA-1 levels as prognostic factors was 0.71 and 0.74, respectively. Conclusion: Serum sPECAM-1 and sICAM-1 levels may be useful for predicting the prognosis of ALF.

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“…We referred to the criteria of Chiba University, Japan, to determine the indications for three levels of emergency LDLT: [4] (1) subacute type (between 11 days and 8 weeks), (2) acute type with liver atrophy, and (3) acute type with no liver atrophy. The national guidelines were referred to for level 3 [4]; in other words, when conservative therapy was not found to be an effective treatment for liver failure, then LDLT was considered.…”

Section: Indications For Emergency Ldltmentioning

confidence: 99%

“…Compared to liver transplantation from a deceased donor, living-donor liver transplantation (LDLT) may reduce the waiting time, particularly for patients suffering from hepatic encephalopathy [3]. The survival outcome of LDLT for patients with hepatic encephalopathy is controversial [4,5]. LDLT using a right-lobe graft was shown to improve the overall survival rates of these patients [6,7].…”

Section: Introductionmentioning

confidence: 99%

Emergency versus elective living-donor liver transplantation: a comparison of a single center analysis

et al. 2011

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Living donor liver transplantation for fulminant hepatic failure

Abstract: The LDLT procedure provided satisfactory survival rates for FHF patients.

Cited by 24 publications

References 51 publications

Development of a New Bioartificial Liver Support System Using a Radial-flow Bioreactor

Development of a New Bioartificial Liver Support System Using a Radial-flow Bioreactor

Serum Levels of Soluble Adhesion Molecules as Prognostic Factors for Acute Liver Failure

Emergency versus elective living-donor liver transplantation: a comparison of a single center analysis

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