The aim of this research is to determine the feasibility, responses, and student learning outcomes of e-LKPD (Lembar Kerja Peserta Didik, i.e., Student Worksheets), by using the Culture-Based Integrated Learning Model (MPTBB) on buffer solution material. The research method uses the ADDIE development model which consists of Analysis, Design, Development, Implementation, and Evaluation. The research subjects were determined using purposive sampling with a total of 12 students in Class XI Natural Science 5 (Class XI IPA 5) for small group trials, and 31 students in Class XI IPA 6 for large group trials. The results showed that the developed electronic LKPD was included in the very feasible category with a score of 4.92 on the media aspect and 4.69 on the material aspect. Student responses to the developed LKPD were in the “very good” category with the content quality aspect obtained a score of 4.73; display aspect with a score of 4.70; the usefulness aspect gets a score of 4.70; and on the user aspect a score of 4.75. After using the e-LKPD with a MPTBB in the learning process of buffer solution material, it was found that there was an increase in student learning outcomes with an N-gain score of 0.54 in the medium category. So that this electronic LKPD can be used for learning media on buffer solution material. This e-LKPD is very interesting because it integrates an integrated learning model based on local culture in chemistry learning.