LL-37 and bisphosphonate co-delivery 3D-scaffold with antimicrobial and antiresorptive activities for bone regeneration

Ye, Peng; Yang, Yusheng; Qu, Ying; Yang, Wenxin; Tan, Jiulin; Zhang, Chengmin; Sun, Dong; Zhang, Jie; Zhao, Weikang; Guo, Shuquan; Song, Lei; Hou, Tianyong; Zhang, Zehua; Tang, Yong; Limjunyawong, Nathachit; Xu, Jianzhong; Dong, Shiwu; Dou, Ce; Luo, Fei

doi:10.1016/j.ijbiomac.2024.134091

International Journal of Biological Macromolecules

2024

DOI: 10.1016/j.ijbiomac.2024.134091

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LL-37 and bisphosphonate co-delivery 3D-scaffold with antimicrobial and antiresorptive activities for bone regeneration

Peng Ye,

Yusheng Yang,

Ying Qu

et al.

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Biological Evaluation of LL‐37 Antimicrobial Peptide‐Loaded Biodegradable Barrier Membranes in Guided Bone Regeneration

Pinthonglor,

Jaimalai,

Daranarong

et al. 2024

Journal of Polymer Science

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This study aims to determine the in vitro and in vivo biocompatibility and the differences in LL‐37 releasing patterns of the PLC/Col/LL‐37 sustained releasing membrane and the rapid releasing Col/LL‐37 membrane for use as a barrier membrane in guided bone regeneration. On Days 3 and 7, the PLC/Col/LL‐37 membrane revealed generated osteoclasts, whereas the PLC/Col membrane indicated mature osteoclasts. PLC/Col/LL‐37 was non‐toxic to blood cells and inhibited human albumin adhesion to the surface. A microbial reduction was observed in the Col/LL‐37 membrane, while both PLC/Col/LL‐37 and Col/LL‐37 may have caused early phases of skin sensitization. In animal testing, PLC/Col/LL37 and Col/LL37 exhibited the same levels of inflammation as the control group at all time points, while the different releasing patterns of LL‐37 loaded on PLC/Col/LL‐37 and Col/LL‐37 membranes had no effect on inflammation resolution in rat models.

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Biological Evaluation of LL‐37 Antimicrobial Peptide‐Loaded Biodegradable Barrier Membranes in Guided Bone Regeneration

Pinthonglor,

Jaimalai,

Daranarong

et al. 2024

Journal of Polymer Science

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show abstract

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LL-37 and bisphosphonate co-delivery 3D-scaffold with antimicrobial and antiresorptive activities for bone regeneration

Cited by 1 publication

References 56 publications

Biological Evaluation of LL‐37 Antimicrobial Peptide‐Loaded Biodegradable Barrier Membranes in Guided Bone Regeneration

Biological Evaluation of LL‐37 Antimicrobial Peptide‐Loaded Biodegradable Barrier Membranes in Guided Bone Regeneration

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