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Terriou, Philippe; Hans, E.; Giorgetti, C.; Spach, Jean-Louis; Salzmann, J.; Urrutia, V.; Roulier, R.

doi:10.1023/a:1009435732258

Cited by 83 publications

(25 citation statements)

References 25 publications

(1 reference statement)

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“…The number of TUNEL-positive cells decreased following PTX treatment in DM rats. These findings matches the other studies [ 14 33 34 ]. Najar et al reported that PTX administration increased Sertoli cells and Leydig cells count in non-diabetic rates in comparison to the control groups.…”

Section: Discussionsupporting

confidence: 93%

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Effects of pentoxifylline administration on histomorphological parameters of streptozotocin-induced diabetic rat testes

2015

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The effect of pentoxifylline (PTX) administration on histomorphological parameters of streptozotocin (STZ)-induced type 1 diabetes mellitus (DM) in male rat testes were evaluated. We randomly divided 40 male rats into the following four groups: group 1: control or normal glycemic (NG) rats; group 2 or NG rats that received only normal saline (NS), (NG+NS); group 3 or diabetic rats which were not treated by PTX (DM+vehicle solution (NS)); and group 4 which comprised diabetic rats treated with 50 mg/kg of PTX (DM+PTX). Type 1 DM was induced by intraperitoneal injection of STZ (55 mg/kg). Rats were held for 30 days after which the experimental group received PTX twice daily (25 mg/kg) or NS. After 14 days of treatment by PTX or NS, the left testes from all rats were extracted and prpared for histological study. Apoptotic cells, blood vessel density, and spermatogenesis were evaluated. Data were analyzed by ANOVA test. PTX-treated-diabetic rats showed a significant decrease in number of apoptotic cells and decrease in blood vessel density compared to the DM+NS rats. A significant increase in spermatogenesis was observed in the PTX-treated diabetic group, compared to the DM+NS groups. It was concluded that PTX administration to STZ-induced type 1 DM rats affected apoptotic cell number positively. Moreover, blood vessel density significantly decreased and improvements were observed in spermatogenesis.

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Section: Discussionsupporting

confidence: 93%

“…However, its effect in diabetic rats were significant [ 14 ]. Mc kinneyet et al and Terriou reported that PTX improved testes function and the blood supplies; as a result, it caused a remarkable increase in the sperm motility in abnormal testes [ 33 34 ].…”

Section: Discussionmentioning

confidence: 99%

Effects of pentoxifylline administration on histomorphological parameters of streptozotocin-induced diabetic rat testes

2015

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“…In previous experimental as well as clinical studies, the role of in vitro application of PX on motility of spermatozoa retrieved from different sources of ejaculate, epididymis, and testis were investigated (18) . Pentoxifylline is phosphodiesterase inhibitor that inhibits the breakdown of cyclic adenosine monophosphate (cAMP) (19) . Asthenozoospermia is one of the major causes of infertility or reduced fertility in men (20) .…”

Section: Introductionmentioning

confidence: 99%

A New Sperm Preparation Technique by Glass Wool Filtration Combined with Pentoxifylline Techniques versus Glass Wool Filtration alone for Infertile and Fertile Men

Kadhim¹

2017

IJEIR

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“…In cases of a positive test, a slight noticeable tail twitching is seen, and in rare occasions, vigorous twisting may be observed. [323334] Motile sperm is picked up using the microinjection pipette and transferred to a fresh microdroplet of sperm medium. This step is repeated several times to wash out any residual pentoxifylline (PF) since it has been suggested in animal studies that PF is embryotoxic.…”

Section: Introductionmentioning

confidence: 99%

Laboratory handling of epididymal and testicular spermatozoa: What can be done to improve sperm injections outcome

Esteves¹,

Varghese²

2012

J Hum Reprod Sci

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Spermatozoa from azoospermic males can be retrieved from either the epididymis or the testis, depending on the type of azoospermia, using different surgical methods such as percutaneous epididymal sperm aspiration (PESA), testicular sperm aspiration (TESA), testicular sperm extraction (TESE), and microsurgical testicular sperm extraction (micro- TESE). After collecting the epididymal fluid or testicular tissue, laboratory techniques are used to remove contaminants, cellular debris, noxious microorganisms, and red blood cells. Processed spermatozoa may be used for intracytoplasmic sperm injection or eventually be cryopreserved. However, spermatozoa collected from either the epididymis or the testis are often compromised and more fragile than ejaculated ones. Therefore, sperm processing techniques should be used with great caution to avoid jeopardizing the sperm fertilizing potential in treatment cycles. In this review, we describe the current methods for processing surgically-retrieved specimens, either fresh or frozen- thawed, and provide the tips and pitfalls for facilitating the handling of such specimens. In addition, we present the available laboratory tools to aid in the identification of viable immotile spermatozoa to be used in conjunction with assisted reproductive techniques. Review of the literature was carried out using PubMed and Science Direct search engines.

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Untitled

Cited by 83 publications

References 25 publications

Effects of pentoxifylline administration on histomorphological parameters of streptozotocin-induced diabetic rat testes

Effects of pentoxifylline administration on histomorphological parameters of streptozotocin-induced diabetic rat testes

A New Sperm Preparation Technique by Glass Wool Filtration Combined with Pentoxifylline Techniques versus Glass Wool Filtration alone for Infertile and Fertile Men

Laboratory handling of epididymal and testicular spermatozoa: What can be done to improve sperm injections outcome

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