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Krylova, E.; Ivanov, A. V.; Orlovski, V.; Эль-Регистан, Г. И.; Баринов, С. М.

doi:10.1023/a:1013603106502

Cited by 16 publications

(5 citation statements)

References 7 publications

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“…CMC-based hydrogels can be considered very good matrices thanks to the good biocompatibility, low toxicity and low degradation rate of CMC polymer in comparison to other polysaccharides [44,45]. The composite material can be obtained by co-precipitation of HA with CMC [46,47] or by incorporation of HA nanocrystals into the hydrogel matrix. The latter strategy allows a better control of the cross-linking degree and therefore of the mechanical properties of the hydrogel [48].…”

Section: Medical Applications Of Injectable Polysaccharide Hydrogelsmentioning

confidence: 99%

New Formulations of Polysaccharide-Based Hydrogels for Drug Release and Tissue Engineering

Camponeschi

Atrei

Rocchigiani

et al. 2015

Gels

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Polysaccharide-based hydrogels are very promising materials for a wide range of medical applications, ranging from tissue engineering to controlled drug delivery for local therapy. The most interesting property of this class of materials is the ability to be injected without any alteration of their chemical, mechanical and biological properties, by taking advantage of their thixotropic behavior. It is possible to modulate the rheological and chemical-physical properties of polysaccharide hydrogels by varying the cross-linking agents and exploiting their thixotropic behavior. We present here an overview of our synthetic strategies and applications of innovative polysaccharide-based hydrogels: hyaluronan-based hydrogel and new derivatives of carboxymethylcellulose have been used as matrices in the field of tissue engineering; while guar gum-based hydrogel and hybrid magnetic hydrogels, have been used as promising systems for targeted controlled drug release. Moreover, a new class of materials, interpenetrating hydrogels (IPH), have been obtained by mixing various native thixotropic hydrogels. OPEN ACCESSGels 2015, 1 4

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Section: Medical Applications Of Injectable Polysaccharide Hydrogelsmentioning

confidence: 99%

New Formulations of Polysaccharide-Based Hydrogels for Drug Release and Tissue Engineering

Camponeschi

Atrei

Rocchigiani

et al. 2015

Gels

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“…Alginate is a safe biocompatible polysaccharide and has been used in food products and tissue engineering. HAp-alginate composites have been recognized as bioactive matrices for both drug delivery and bone regeneration [10][11][12][13].…”

Section: Bioceramics 21mentioning

confidence: 99%

Therapeutic Effects of Paclitaxel-Loaded Hydroxyapatite-Alginate Beads: <i>In Vitro </i> and <i>In Vivo</i> Studies

Abe

Sakane

Ikoma³

et al. 2008

KEM

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Several drug delivery carriers have reported on local delivery of paclitaxel (PTX), but their effects on intraosseous cancer model are not well known. This study was conducted to clarify the therapeutic effects of our newly developed PTX-loaded HAp-alginate composite beads. Cytotoxic activity was assessed on rat’s mammary adenocarcinoma by cell proliferation assay using WST-1 reagent. Antitumor activity was assessed by 8-week-old rat female Fischer 344 rats of metastatic spine cancer. Twenty-three rats were divided into 3 groups: Group 1 (n = 7) and Group 2 (n = 8) was treated with the PTX-loaded HAp-alginate beads using strontium ions and barium ions, respectively. Group 3 (n = 8) was administered with drug-free HAp-alginate beads. We checked disease-free time and survival time among 3 groups. The HAp-alginate beads containing 2.4wt% of PTX showed significant cytotoxic activity on CRL-1666 cells. The effects were decreased with time during 72 h. The animals treated with 2.4wt% of PTX-loaded HAp-alginate beads showed 40% increase in the disease-free time and 25% increase in survival time. Our studies suggest that newly developed HAp-alginate beads can be a candidate carrier of PTX to bone.

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“…The use of such a tool of ICT in the study of new material provides an opportunity to improve students' spatial imagination, "see" and better understand the learning material, which will contribute to better learning and the formation of certain practical skills [13]. From the augmented reality platforms and applications discussed above, we chose to work with Blippar.…”

Section: Introductionmentioning

confidence: 99%

The use of augmented reality in chemistry lessons in the study of “Oxygen-containing organic compounds” using the mobile application Blippar

Karnishyna

Selivanova

Nechypurenko

et al. 2022

J. Phys.: Conf. Ser.

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A training kit has been created to study the topic of “Oxygen-containing organic compounds” using augmented reality. We chose the Blippar platform to work, it is quite simple and relatively free. The kit contains markers we have developed, on which, with the camera from the Blippar application, students will be able to observe thematic experiments and molecules of individual substances with the help of augmented reality. There was also a study on the effectiveness of our developments to implement augmented reality in the course of chemistry. The study results showed an increase in pupils’ motivation to study chemistry and their level of interest, facilitating the perception of the theoretical foundations of organic chemistry related to the spatial structure of molecules. Also, the use of augmented reality technologies creates the conditions for improving the level of digital and technological competencies of students, provides support for high quality teaching of chemistry in distance learning.

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Untitled

Cited by 16 publications

References 7 publications

New Formulations of Polysaccharide-Based Hydrogels for Drug Release and Tissue Engineering

New Formulations of Polysaccharide-Based Hydrogels for Drug Release and Tissue Engineering

Therapeutic Effects of Paclitaxel-Loaded Hydroxyapatite-Alginate Beads: <i>In Vitro </i> and <i>In Vivo</i> Studies

The use of augmented reality in chemistry lessons in the study of “Oxygen-containing organic compounds” using the mobile application Blippar

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