LMN diet, rich in polyphenols and polyunsaturated fatty acids, improves mouse cognitive decline associated with aging and Alzheimer's disease

Fernández-Fernández, Laura; Comes, Gemma; Bolea, Irène; Valente, Tony; Ruiz, Jessica; Murtra, Patricia; Ramírez, Bartolomé; Anglés, Neus; Reguant, Jordi; Morelló, José Ramón; Boada, Merçé; Hidalgo, Juan; Escorihuela, Rosa M.; Unzeta, Mercedes

doi:10.1016/j.bbr.2011.11.014

Cited by 60 publications

(36 citation statements)

References 69 publications

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“…LMN diet rich in polyphenols, dry fruits and cocoa, was able to decrease behavioral deterioration caused by aging and Tg2576 genotype and to delay the Aβ plaque formation. These results corroborate the increasing importance of polyphenols as human dietary supplements in amelioration of the cognitive impairment during aging and neurological disorders such as AD [42] . At present, there is mounting evidence that alterations in dietary intake could be beneficial for preventing and treating oxidative disorders and neurodegenerative illnesses such as AD, which could offer an alternative or supplementary therapy.…”

Section: Polyphenol Ellagic Acid-targeting To Brain: a Hidden Treasuresupporting

confidence: 83%

Polyphenol Ellagic Acid-Targeting To Brain: A Hidden Treasure

Mehan¹,

Kaur²,

Parveen³

et al. 2015

International Journal of Neurology Research

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Alzheimer's disease is a severe neurodegenerative disorder that gradually results in loss of memory and impairment of cognitive functions in the elderly.Thedeposition of amyloid plaques is the primary event that leads to an oxidative and inflammatory reactions, neurofibrillary tangle formation, and ultimately neuronal death. The most prominent losses occur with cholinergic neurons that plays an important role in the formation of memory and cognitive functions. Insulin receptor numbers also altered, thusglucosemetabolism is defected in AD. Polyphenol ellagic acid (EA) possesses antioxidant, anti-inflammatory, anti-carcinogenic, anti-diabetic and cardioprotection activities.Activities of EA that are linked with protection of neuronal abnormalities like anti-depressant, antianxiety, anti-nociception. Ellagic acid inhibits β-secretase enzymatic activities, thus prevents the main pathologic hallmark of AD. There are varieties of herbal extracts and phytochemicals formulations extensively used to provide symptomatic relief to AD patients. Together these results our hypothesis that EA may prevent the neuronal dysfunctions as well as further work is also required to examine the pharmacological properties of EA in the protection of specially neurodegenerative disorder like AD. Here, we discuss how we can use the knowledge to improve treatment strategies of EA in AD and to explore the various signaling pathways involved in the progression of neuronal death.

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Section: Polyphenol Ellagic Acid-targeting To Brain: a Hidden Treasuresupporting

confidence: 83%

Polyphenol Ellagic Acid-Targeting To Brain: A Hidden Treasure

Mehan¹,

Kaur²,

Parveen³

et al. 2015

International Journal of Neurology Research

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“…[34][35][36] Perhaps the presence of such foods in the gut may favor certain bacteria that, in turn, facilitate maintenance of factors that are neuroprotective. 37 It is possible that these foods may influence b-amyloid or tau metabolism; evidence for these mechanisms are largely from animal studies 38,39 and require further assessment and confirmation. Moreover, the literature is even more limited for the influence of these dietary patterns on individual cognitive domains.…”

Section: Resultsmentioning

confidence: 99%

Relation of DASH- and Mediterranean-like dietary patterns to cognitive decline in older persons

Tangney¹,

Li²,

Wang³

et al. 2014

Neurology

235

159

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Objectives: We examined whether accordance to the DASH (Dietary Approach to Stop Hypertension) and Mediterranean diets is associated with slower cognitive decline in a prospective Chicago cohort study of older persons, the Memory and Aging Project. Methods:The sample comprised 826 Memory and Aging Project participants (aged 81.5 6 7.1 years) who completed a 144-item food frequency questionnaire at baseline and 2 or more cognitive assessments over 4.1 years. Dietary scores were computed for accordance to the DASH diet (0-10) and the Mediterranean diet (MedDietScore) (0-55). For both, higher scores reflect greater accordance. Both patterns share at least 3 common food components. Cognitive function was assessed annually with 19 cognitive tests from which global cognitive scores and summary measures are computed. Results:The mean global cognitive score at baseline was 0.12 (range, 23.23 to 1.60) with an overall mean annual change in score of 20.08 standardized units. Only 13 participants had possible dementia. The mean DASH score was 4.1 (range, 1.0-8.5) and the MedDietScore was 31.3 (range, 18-46). In mixed models adjusted for covariates, a 1-unit difference in DASH score was associated with a slower rate of global cognitive decline by 0.007 standardized units (standard error of estimate 5 0.003, p 5 0.03). Similarly, a 1-unit-higher MedDietScore was associated with a slower rate of global cognitive decline by 0.002 standardized units (standard error of estimate 5 0.001, p 5 0.01).Conclusions: These findings support the hypothesis that both the DASH and Mediterranean diet patterns are associated with slower rates of cognitive decline in the same cohort of older persons.

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“…Reductions of amyloid deposition, A" oligomer levels, inflammation, or oxidative stress in the brain with attenuation of cognitive deterioration have been reported in transgenic mouse models treated with: Cur (Lim et al 2001;Yang et al 2005;Hamaguchi et al 2009;Ray et al 2011), EGCG (Rezai-Zadeh et al 2005, Myr (Hamaguchi et al 2009), RA (Hamaguchi et al 2009), resveratrol (Karuppagounder et al 2009;Capiralla et al 2012;Solberg et al 2014;Porquet et al 2014), tannic acid (Mori et al 2012), FA (Mori et al 2013), rutin (a glycone of quercetin) (Xu et al 2014), oleuropein (Grossi et al 2013), hopeahainol A , grape seed polyphenolic extract (GSPE) Liu et al 2011), proanthocyanidins of GSPE (Wang et al 2012), red wine/its polyphenolic contents (Wang et al 2006;Ho et al 2009a), anthocyanin-enriched blueberry and blackcurrant 3)] exert inhibitory effects through different binding to A". Details of the studies were described in the reference (Ono et al 2012) extracts (Vepsäläinen et al 2013), pomegranate juice containing high levels of polyphenols (Hartman et al 2006), and a natural diet rich in polyphenols and polyunsaturated fatty acids (LMN diet) (Fernández-Fernández et al 2012). Other models include an A"-infused rat AD model treated with Cur (Hoppe et al 2013), and a transgenic Caenohabditis elegans model of A" amyloidosis treated with quercetin (Regitz et al 2014) and oleuropein (Diomede et al 2013;Grossi et al 2014).…”

Section: Studies With In Vivo Models Of Cerebral Amyloidosismentioning

confidence: 99%

Natural Phenolic Compounds as Therapeutic and Preventive Agents for Cerebral Amyloidosis

Yamada

Ono

Hamaguchi

et al. 2015

Advances in Experimental Medicine and Biology

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Epidemiological studies have suggested that diets rich in phenolic compounds may have preventive effects on the development of dementia or Alzheimer's disease (AD). We investigated the effects of natural phenolic compounds, such as myricetin (Myr), rosmarinic acid (RA), ferulic acid (FA), curcumin (Cur) and nordihydroguaiaretic acid (NDGA) on the aggregation of amyloid β-protein (Aβ), using in vitro and in vivo models of cerebral Aβ amyloidosis. The in vitro studies revealed that these phenolic compounds efficiently inhibit oligomerization as well as fibril formation of Aβ through differential binding, whilst reducing Aβ oligomer-induced synaptic and neuronal toxicity. Furthermore, a transgenic mouse model fed orally with such phenolic compounds showed significant reduction of soluble Aβ oligomers as well as of insoluble Aβ deposition in the brain. These data, together with an updated review of the literature, indicate that natural phenolic compounds have anti-amyloidogenic effects on Aβ in addition to well-known anti-oxidative and anti-inflammatory effects, hence suggesting their potential as therapeutic and/or preventive agents for cerebral Aβ amyloidosis, including AD and cerebral amyloid angiopathy (CAA). Well-designed clinical trials or preventive interventions with natural phenolic compounds are necessary to establish their efficacy as disease-modifying agents.

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LMN diet, rich in polyphenols and polyunsaturated fatty acids, improves mouse cognitive decline associated with aging and Alzheimer's disease

Cited by 60 publications

References 69 publications

Polyphenol Ellagic Acid-Targeting To Brain: A Hidden Treasure

Polyphenol Ellagic Acid-Targeting To Brain: A Hidden Treasure

Relation of DASH- and Mediterranean-like dietary patterns to cognitive decline in older persons

Natural Phenolic Compounds as Therapeutic and Preventive Agents for Cerebral Amyloidosis

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