No abstract

SummaryGAS6 (growth arrest-specific 6) belongs structurally to the familyofplasma vitamin K-dependentproteins. GAS6 has ahigh structural homologyw ith the natural anticoagulant protein S, sharing the same modular composition and having 40% sequence identity.Despite this,the lowconcentration of GAS6 in plasma and the pattern of tissue expression of GAS6 suggest a distinctf unctiona mongv itamin-Kd ependent proteins.Indeed, GAS6 has growth factor-likepropertiesthroughits interaction with receptor tyrosine kinases of theTAM family;Ty ro3,Axl and MerTK. GAS6 employs au nique mechanism of action, interacting throughits vitamin K-dependent GLA (γ-carboxyglutamic acid) module with phosphatidylserine-containingm embranes and throughits carboxy-terminal LamGdomainswith the TA M Keywords Vitamin K, growth factors,innateimmunity,inflammation,receptor tyrosine kinases,GLA membraner eceptors.During the last years thereh as been a considerableexpansionofour knowledge of thebiology ofTA M receptors that has lead to aclear pictureoftheir importance in inflammation,haemostasis and cancer, makingthis system an interesting targeti nb iomedicine.The innate immune response andt he coagulationc ascade have been shownt ob ei nterconnected.Mediators of inflammationare essentialinthe initiation and propagationofthe coagulationcascade,while natural anticoagulants have important anti-inflammatoryf unctions.GAS6 represents anew playerinthis context,while proteinSseemsto have newfunctions beyond its anticoagulant role through its interaction with TA Mreceptors.

LMN diet could benefit the cognitive reserve reducing Alzheimer's disease risk.