LncRNA: a new perspective on the study of neurological diseases

Abstract

Long non-coding RNAs (lncRNAs) are a class of non-coding RNA with a length greater than 200 nt. It has a mRNA-like structure, formed by splicing after transcription, and contains a polyA tail and a promoter, of whom promoter plays a role by binding transcription factors. LncRNAs’ sequences are low in conservation, and other species can only find a handful of the same lncRNAs as humans, and there are different splicing ways during the differentiation of identical species, with spatiotemporal expression specificity. With developing high-throughput sequencing and bioinformatics, found that more and more lncRNAs associated with nervous system disease. This article deals with the regulation of certain lncRNAs in the nervous system disease, by mean of to understand its mechanism of action, and the pathogenesis of some neurological diseases have a fresh understanding, deposit a foundation for resulting research and clinical treatment of disease.

Role of lncRNAs in acute pancreatitis: pathogenesis, diagnosis, and therapy

“…At different subcellular localizations, lncRNAs can regulate physiological and pathological cellular activities by genomic expression modulation, epigenetic modification, and post-transcriptional regulation in cis or in trans by interacting with chromatins, proteins, and RNAs in the nucleus or cytoplasm ( Chen, 2016 ). LncRNAs are aberrantly expressed and found to be involved in the occurrence and development of many diseases, such as cancers ( Tan et al, 2021 ), cardiovascular diseases ( Huang, 2018 ), neurological diseases ( Ma et al, 2022 ), and intestinal diseases ( Chen et al, 2018 ). In recent years, lncRNAs have been found to play critical roles in the molecular mechanism, diagnosis, and therapy of AP.…”