LncRNA AK085865 depletion ameliorates asthmatic airway inflammation by modulating macrophage polarization

Pei, Wenjun; Zhang, Yingying; Luo, Mengsha; Chen, Tianbing; Zhang, Mengying; Zhong, Min; Lv, Kun

doi:10.1016/j.intimp.2020.106450

Cited by 35 publications

(26 citation statements)

References 24 publications

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“…In addition to the common tissue tropism, AAD also have obvious inflammatory patterns, including eosinophils, M2 macrophages, ILC2s, IgE secreting B cells and Th2 cells, and cytokines, including IL-33, IL-4, IL-5 and IL-13 (114,115). Reduction of Th2 cytokines (IL-4, IL-5 and IL-13), macrophages, ILC2s and other cells in lung tissues, and alveolar lavage fluid, can improve allergic airway inflammation in mice, which may be a potential way to treat allergic asthma (58,116).…”

Section: Allergic Airway Diseases (Aad)mentioning

confidence: 99%

A crosstalk between type 2 innate lymphoid cells and alternative macrophages in lung development and lung diseases (Review)

Zhu

Lü

2021

Mol Med Rep

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Type 2 innate lymphoid cells (ILC2s) are important innate immune cells that are involved in type 2 inflammation, in both mice and humans. ILC2s are stimulated by factors, including interleukin (IL)-33 and IL-25, and activated ILC2s secrete several cytokines that mediate type 2 immunity by inducing profound changes in physiology, including activation of alternative (M2) macrophages. M2 macrophages possess immune modulatory, phagocytic, tissue repair and remodeling properties, and can regulate ILC2s under infection. The present review summarizes the role of ILC2s as innate cells and M2 macrophages as anti-inflammatory cells, and discusses current literature on their important biological significance. The present review also highlights how the crosstalk between ILC2s and M2 macrophages contributes to lung development, induces pulmonary parasitic expulsion, exacerbates pulmonary viral and fungal infections and allergic airway diseases, and promotes the development of lung diseases, such as pulmonary fibrosis, chronic obstructive pulmonary disease and carcinoma of the lungs. Contents

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Section: Allergic Airway Diseases (Aad)mentioning

confidence: 99%

A crosstalk between type 2 innate lymphoid cells and alternative macrophages in lung development and lung diseases (Review)

Zhu

Lü

2021

Mol Med Rep

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“…H19 was found differentially expressed in OVA mice in our microarray analysis, thus, H19 could also potentially regulate inflammation of asthma by targeting goblet cells. LncRNA-AK085865 depletion can ameliorate the inflammation of dermatophagoides farinae protein 1-induced allergic asthma by modulation macrophage polarization (Pei et al 2020 ). In human patients with asthma, lncRNA-MEG3 regulated Treg/Th17 balance (Qiu et al 2019 ).…”

Section: Discussionmentioning

confidence: 99%

LncRNA-AK149641 associated with airway inflammation in an OVA-induced asthma mouse model

Zhang

Zhou

et al. 2020

J Bioenerg Biomembr

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Asthma is defined as a heterogeneous disease, usually characterized by chronic airway inflammation. Long noncoding RNAs (lncRNAs) play important roles in various biological processes. To know more about the relationships between lncRNAs and asthma, gene microarray analysis was performed to screen differentially expressed lncRNAs between the lung tissue of ovalbumin (OVA) mice and control mice. Further studies showed that downregulating differentially expressed lncRNA-AK149641 by adeno-associated virus 6 (AAV6) in OVA mice inhibited airway inflammation, with improved airway compliance and resistance, diminished infiltration of inflammatory cells, as well as less secretions of mucus, tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6). Moreover, the activity of nuclear factor-kappa B (NF-κB) in the lung tissue was reduced after downregulating lncRNA-AK149641. In conclusion, we proposed that downregulation of lncRNA-AK149641 attenuated the airway inflammatory response in an OVA-induced asthma mouse model, probably in association with modulation of the NF-κB signaling pathway.

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“…However, Esser et al demonstrated that these macrophage-derived exosomes carried different enzymes implicated in LT biosynthesis, particularly LTB 4 , which is a potent chemoattractant agent for eosinophils and neutrophils [192]. Moreover, a recent study demonstrated that exosomes from M2 macrophages induced the differentiation of ILCs progenitors to ILC2, a potent source of immune effector cytokines in asthma [193].…”

Section: Exosomes From Other Cellular Populations Implicated In Asthma Pathologymentioning

confidence: 99%

Exosomes: A Key Piece in Asthmatic Inflammation

Cañas

Rodrigo‐Muñoz

Gil-Martínez

et al. 2021

IJMS

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Asthma is a chronic disease of the airways that has an important inflammatory component. Multiple cells are implicated in asthma pathogenesis (lymphocytes, eosinophils, mast cells, basophils, neutrophils), releasing a wide variety of cytokines. These cells can exert their inflammatory functions throughout extracellular vesicles (EVs), which are small vesicles released by donor cells into the extracellular microenvironment that can be taken up by recipient cells. Depending on their size, EVs can be classified as microvesicles, exosomes, or apoptotic bodies. EVs are heterogeneous spherical structures secreted by almost all cell types. One of their main functions is to act as transporters of a wide range of molecules, such as proteins, lipids, and microRNAs (miRNAs), which are single-stranded RNAs of approximately 22 nucleotides in length. Therefore, exosomes could influence several physiological and pathological processes, including those involved in asthma. They can be detected in multiple cell types and biofluids, providing a wealth of information about the processes that take account in a pathological scenario. This review thus summarizes the most recent insights concerning the role of exosomes from different sources (several cell populations and biofluids) in one of the most prevalent respiratory diseases, asthma.

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LncRNA AK085865 depletion ameliorates asthmatic airway inflammation by modulating macrophage polarization

Cited by 35 publications

References 24 publications

A crosstalk between type 2 innate lymphoid cells and alternative macrophages in lung development and lung diseases (Review)

A crosstalk between type 2 innate lymphoid cells and alternative macrophages in lung development and lung diseases (Review)

LncRNA-AK149641 associated with airway inflammation in an OVA-induced asthma mouse model

Exosomes: A Key Piece in Asthmatic Inflammation

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