LncRNA-AK149641 associated with airway inflammation in an OVA-induced asthma mouse model

Zhang, Jie; Zhou, Yao; Gu, Haiyan; Zhang, Jiamin; Tang, Heng; Rong, Qiangquan; Gu, Lina; Pan, Jing; Zhao, Deyu; Liu, Feng

doi:10.1007/s10863-020-09844-6

Cited by 13 publications

(9 citation statements)

References 44 publications

(48 reference statements)

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“…Therefore, IL-6 is a key factor in regulating the pathogenesis of AR induced by the imbalance of Th1 and Th2 differentiation [ 41 ]. The research shows that down-regulated lncRNA-AK149641 can decrease the expression level of TNF- α and IL-6 by the activity of the NF- κ B signaling pathway in OVA mice [ 42 ]. We have mentioned that respiratory syncytial virus (RSV) infection is a risk factor for allergic rhinitis.…”

Section: Introductionmentioning

confidence: 99%

Noncoding RNAs and Virus and Treatment in Allergic Rhinitis

Guo

Wang

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Allergic rhinitis (AR) is a type I hypersensitivity reaction disease caused by inhaled allergens and immunoglobulin E (IgE)-mediated. Noncoding RNA (ncRNA) is an important regulator involved in gene expression and can be detected in the cytoplasm or extracellular fluid, which mainly includes microRNAs (miRNA, length 22–24 nucleotides), long noncoding RNAs (lncRNA, length >200 nucleotides), and circRNAs. LncRNA and miRNA both participate in the regulation of immune function. Some respiratory viral infections can aggravate allergic rhinitis, such as a respiratory syncytial virus (RSV) and human metapneumovirus (hMPV). However, the interaction between viral infection and allergy is complex and the mechanism is still unclear. In this review, we summarized the interactions of noncoding RNAs and viruses in the occurrence and development of AR, along with the treatments focusing on the noncoding RNAs in the past five years.

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Section: Introductionmentioning

confidence: 99%

Noncoding RNAs and Virus and Treatment in Allergic Rhinitis

Guo

Wang

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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“…The asthma model, which is characterized by airway inflammation, can be induced by OVA stimulation for less than 30 days [ 9 ]. In this study, to establish asthma model characterized by airway remodeling, we prolonged OVA stimulation to 8 weeks.…”

Section: Discussionmentioning

confidence: 99%

“…LncRNA BCYRN1 could facilitate the proliferation and migration of ASMCs of asthmatic rat through up-regulation of transient receptor potential [ 8 ]. Down-regulating lncRNA-AK149641 in OVA-induced asthmatic mice could alleviate airway inflammation, mucus secretions, decrease expression of interleukin-6 and tumor necrosis factor alpha [ 9 ]. LncRNA Malat1 could inhibit the platelet-derived growth factor BB mediated ASMCs proliferation and migration through miR-150-eIF4E/Akt Signaling in the airway remodeling in asthma [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

“…They suggested that ANO7, PYCR1 and UBE2C might play a central roles in the HDM- and OVA-induced allergic inflammatory asthma. Zhang et al [ 9 ] performed gene microarray analysis on lung tissues of OVA-induced asthmatic mice (30 days), and indicated that the lncRNA-AK149641 may serve as a promising target for the treatment of asthma. However, the microarray analysis on lung tissues from the OVA-induced chronic airway remodeling (8 weeks) mouse model is lacking.…”

Section: Introductionmentioning

confidence: 99%

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Gene expression profiles and bioinformatics analysis in lung samples from ovalbumin-induced asthmatic mice

Song

Jiang²,

Bai³

et al. 2023

BMC Pulm Med

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Background Asthma is characterized by chronic inflammation and airway remodeling. However, limited study is conducted on the gene expression profiles of ovalbumin (OVA) induced asthma in mice. Here, we explored the gene expression profiles in lung tissues from mice with OVA-induced asthma using microarray and bioinformatics analysis. Methods For establishment of OVA-induced asthma model, mice first received intraperitoneal sensitization with OVA on day 0, 7 and 14, followed by atomizing inhalation of OVA 3 times a week for 8 weeks. The lung tissues were collected and subjected to microarray analysis, bioinformatics analysis and expression validation. Results Microarray data of lung tissues suggested that 3754 lncRNAs and 2976 mRNAs were differentially expressed in lung tissues between control and asthmatic mice, including 1647 up-regulated and 2106 down-regulated lncRNAs, and 1201 up-regulated and 1766 down-regulated mRNAs. GO analysis displayed that the up-regulated genes were enriched in inflammatory response, leukocyte migration involved in inflammatory response, and Notch signaling pathway. KEGG pathway analysis indicated that the enriched pathway terms of the up-regulated gene included Toll-like receptor signaling pathway and Th17 cell differentiation signaling pathway. Additionally, based on the previously published literatures on asthma and inflammation, we screened out down-regulated genes, such as Smg7, Sumo2, and Stat5a, and up-regulated genes, such as Myl9, Fos and Tlr4. According to the mRNA-lncRNA co-expression network, we selected lncRNAs associated with above genes, including the down-regulated lncRNAs of NONMMUT032848, NONMMUT008873, NONMMUT009478, and NONMMUT006807, and the up-regulated lncRNAs of NONMMUT052633, NONMMUT05340 and NONMMUT042325. The expression changes of the above genes were validated in lung tissues by real-time quantitaive PCR and Western blot. Conclusions Overall, we performed gene microarray on lung samples from OVA-induced asthmatic mice and summarized core mRNAs and their related lncRNAs. This study may provide evidence for further research on the therapeutic targets of asthma.

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“…Moreover, the literature has reported that lncRNA expression profiles in immune cells of AR patients and animal models are equally cell-specific [144,145]. Ma [118] lncRNA-TUG1 Downregulation miR-29c/B7-H3 Promote Th2 cell differentiation [20] lncRNA-AK085-865 Downregulation Unknown Ameliorate inflammation [119] lncRNA-BCYRN1 Downregulation miRNA-150 Inhibit the proliferation of ASMCs [113] lncRNA-LINCPINT Downregulation miRNA-265p/PTEN Retard the abnormal growth of ASMCs [120] circRNA-0005519 Upregulation miRNA-7a-5p Increase IL-6/IL-13levels [82] circRNA-HIPK3 Upregulation miR-326/STIM1; miR-375/MMP-16 Modulate the proliferation of AMSCs [85,121] circRNA-0002594 Upregulation Unknown Upregulate in CD4 + T cells [86] CircRNA-ZNF652 Upregulation miR-452-5p/JAK2 Promote the goblet cell metaplasia [122] circRNA-ERBB2 Downregulation miR-98-5p/IGF1R Increase infiltration [123] 6 Mediators of Inflammation et al [146] found that the expression profiles of lncRNAs were significantly cell-specific and involved multiple signaling pathways associated with AR disease development by comparing the expression profiles of lncRNAs in CD4 + T cells from AR mouse models and control mice by sequencing. In parallel, some lncRNAs have been proven to be potential biomarkers for assessing AR severity and progno-sis.…”

Section: Lncrna and Armentioning

confidence: 99%

The Role of Noncoding RNA in Airway Allergic Diseases through Regulation of T Cell Subsets

Cheng

Tang

Xie

et al. 2022

Mediators of Inflammation

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Allergic rhinitis and asthma are common airway allergic diseases, the incidence of which has increased annually in recent years. The human body is frequently exposed to allergens and environmental irritants that trigger immune and inflammatory responses, resulting in altered gene expression. Mounting evidence suggested that epigenetic alterations were strongly associated with the progression and severity of allergic diseases. Noncoding RNAs (ncRNAs) are a class of transcribed RNA molecules that cannot be translated into polypeptides and consist of three major categories, microRNAs (miRNAs), long noncoding RNAs (lncRNAs), and circular RNAs (circRNAs). Previous studies showed that ncRNAs were involved in the physiopathological mechanisms of airway allergic diseases and contributed to their occurrence and development. This article reviews the current state of understanding of the role of noncoding RNAs in airway allergic diseases, highlights the limitations of recent studies, and outlines the prospects for further research to facilitate the clinical translation of noncoding RNAs as therapeutic targets and biomarkers.

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LncRNA-AK149641 associated with airway inflammation in an OVA-induced asthma mouse model

Cited by 13 publications

References 44 publications

Noncoding RNAs and Virus and Treatment in Allergic Rhinitis

Noncoding RNAs and Virus and Treatment in Allergic Rhinitis

Gene expression profiles and bioinformatics analysis in lung samples from ovalbumin-induced asthmatic mice

The Role of Noncoding RNA in Airway Allergic Diseases through Regulation of T Cell Subsets

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