LncRNA CASC2 inhibits hypoxia-induced pulmonary artery smooth muscle cell proliferation and migration by regulating the miR-222/ING5 axis

Yan, Han; Wang, Kun; Yang, Chaokuan; Gao, Chuanyu; Guo, Xiaoyan; Cheng, Jiangtao

doi:10.1186/s11658-020-00215-y

Cited by 25 publications

(23 citation statements)

References 34 publications

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“…LncRNAs TUG1 and NONRATT015587.2, as ceRNAs, have been reported to have an impact on vascular remodelling in PH [ 25 , 26 ]. LncRNA CASC2 and Hoxaas3 regulate PASMC proliferation and migration in HPH by influencing the expression of miR-222 and homeobox a3, respectively [ 27 , 28 ]. LncRNA PAXIP1-AS1 plays an important role in PH by affecting PH-specific transcriptional programmes [ 29 ].…”

Section: Discussionmentioning

confidence: 99%

Construction and analysis of the abnormal lncRNA–miRNA–mRNA network in hypoxic pulmonary hypertension

et al. 2021

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The incidence of hypoxic pulmonary hypertension (HPH) is increasing. Accumulating evidence suggests that long non-coding RNAs (lncRNAs) play an important role in HPH, but the functions and mechanism have yet to be fully elucidated. In this study, we established an HPH rat model with 8 h of hypoxia exposure (10% O2) per day for 21 days. High-throughput sequencing identified 60 differently expressed (DE) lncRNAs, 20 DE miRNAs and 695 DE mRNAs in rat lung tissue. qRT-PCR verified the accuracy of the results. Immune response, inflammatory response, leukocyte migration, cell cycle, cellular response to interleukin-1, IL-17 signalling pathway, cytokine-cytokine receptor interaction and Toll-like receptor signalling pathway were significantly enriched in DE mRNAs. According to the theory of competing endogenous RNA (ceRNA) networks, lncRNA-miRNA-mRNA network was constructed by Cytoscape software, including 7 lncRNAs, 16 miRNAs and 144 mRNAs. The results suggested that seven DE lncRNAs (Ly6l, AABR07038849.2, AABR07069008.2, AABR07064873.1, AABR07001382.1, AABR07068161.1 and AABR07060341.2) could serve as molecular sponges of the corresponding miRNAs and play a major role in HPH.

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Section: Discussionmentioning

confidence: 99%

Construction and analysis of the abnormal lncRNA–miRNA–mRNA network in hypoxic pulmonary hypertension

et al. 2021

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“…In recent years, increasing evidence has demonstrated that lncRNAs play important roles in the development of various tissues, such as the brain [ 29 ], liver [ 30 ], heart [ 31 ], testis [ 32 ], ovary [ 33 ], kidney, uterus [ 34 ], muscle [ 35 ], mammary gland [ 36 ], and inner ear [ 37 ]. However, few studies have been conducted on the potential role of lncRNAs in mammalian hair follicle development and wool curvature.…”

Section: Discussionmentioning

confidence: 99%

Integrated Analysis of lncRNA and mRNA Reveals Novel Insights into Wool Bending in Zhongwei Goat

Liu²,

et al. 2021

Animals

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Chinese Zhongwei goat is a rare and precious fur breed as its lamb fur is a well-known fur product. Wool bending of lamb fur of the Zhongwei goat is its most striking feature. However, the curvature of the wool decreases gradually with growth, which significantly affects its quality and economic value. The mechanism regulating the phenotypic changes of hair bending is still unclear. In the present study, the skin tissues of Zhongwei goats at 45 days (curving wool) and 108 days (slight-curving wool) after birth were taken as the research objects, and the expression profiling of long non-coding RNAs (lncRNAs) and mRNAs were analyzed based on the Ribo Zero RNA sequencing (RNA-seq) method. In total, 46,013 mRNAs and 13,549 lncRNAs were identified, of which 352 were differentially expressed mRNAs and 60 were. lncRNAs. Functional enrichment analysis of the target genes of lncRNAs were mainly enriched in PI3K-Akt, Arachidonic acid metabolic, cAMP, Wnt, and other signaling pathways. The qRT-PCR results of eight selected lncRNAs and target genes were consistent with the sequencing result, which indicated our data were reliable. Through the analysis of the weighted gene co-expression network, 13 co-expression modules were identified. The turquoise module contained a large number of differential expressed lncRNAs, which were mainly enriched in the PI3K-Akt signaling pathway and cAMP signaling pathway. The predicted LOC102172600 and LOC102191729 might affect the development of hair follicles and the curvature of wool by regulating the target genes. Our study provides novel insights into the potential roles of lncRNAs in the regulation of wool bending. In addition, the study offers a theoretical basis for further study of goat wool growth, so as to be a guidance and reference for breeding and improvement in the future.

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“…miRNAs associated with muscular atrophy in disease are expected to be identified in the future, and they may function by many different mechanisms. In addition, lncRNAs are reported to participate in various physiological and pathological processes, such as cancer ( Lu et al, 2013 ; He et al, 2014 ; Sun et al, 2014 ; Zhuang et al, 2014 ; Yin et al, 2015 ; Zhou et al, 2015 ; Zou et al, 2016 ; Wang J. et al, 2017 ), aging ( Boon et al, 2016 ; Su et al, 2019 ), muscle development ( Ballarino et al, 2018 ; Jin et al, 2018 ; Zhang et al, 2018b ), and their associated disorders ( Han et al, 2020 ). A better understanding of the roles of miRNAs and lncRNAs and their corresponding signaling pathways in regulating skeletal muscle atrophy in cachexia and other diseases will eventually help elucidate the mechanisms underlying muscle wasting and may contribute to the design of new strategies for the prevention, diagnosis, and treatment of muscle-wasting diseases.…”

Section: Discussionmentioning

confidence: 99%

Regulation of Skeletal Muscle Atrophy in Cachexia by MicroRNAs and Long Non-coding RNAs

Chen

Liu

Jiang

et al. 2020

Front. Cell Dev. Biol.

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Skeletal muscle atrophy is a common complication of cachexia, characterized by progressive bodyweight loss and decreased muscle strength, and it significantly increases the risks of morbidity and mortality in the population with atrophy. Numerous complications associated with decreased muscle function can activate catabolism, reduce anabolism, and impair muscle regeneration, leading to muscle wasting. microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), types of non-coding RNAs, are important for regulation of skeletal muscle development. Few studies have specifically identified the roles of miRNAs and lncRNAs in cellular or animal models of muscular atrophy during cachexia, and the pathogenesis of skeletal muscle wasting in cachexia is not entirely understood. To develop potential approaches to improve skeletal muscle mass, strength, and function, a more comprehensive understanding of the known key pathophysiological processes leading to muscular atrophy is needed. In this review, we summarize the known miRNAs, lncRNAs, and corresponding signaling pathways involved in regulating skeletal muscle atrophy in cachexia and other diseases. A comprehensive understanding of the functions and mechanisms of miRNAs and lncRNAs during skeletal muscle wasting in cachexia and other diseases will, therefore, promote therapeutic treatments for muscle atrophy.

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LncRNA CASC2 inhibits hypoxia-induced pulmonary artery smooth muscle cell proliferation and migration by regulating the miR-222/ING5 axis

Cited by 25 publications

References 34 publications

Construction and analysis of the abnormal lncRNA–miRNA–mRNA network in hypoxic pulmonary hypertension

Construction and analysis of the abnormal lncRNA–miRNA–mRNA network in hypoxic pulmonary hypertension

Integrated Analysis of lncRNA and mRNA Reveals Novel Insights into Wool Bending in Zhongwei Goat

Regulation of Skeletal Muscle Atrophy in Cachexia by MicroRNAs and Long Non-coding RNAs

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