lncRNA DANCR promotes tumor progression and cancer stemness features in osteosarcoma by upregulating AXL via miR-33a-5p inhibition

Jiang, Nian; Wang, Xuedi; Xie, Xianbiao; Liao, Yan; Liu, Geoffrey; Liu, Junfeng; Miao, Nabo; Shen, Jingnan; Peng, Tingsheng

doi:10.1016/j.canlet.2017.06.009

Cited by 190 publications

(201 citation statements)

References 30 publications

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“…Therefore, we sequenced miRNAs that are more conservative than lncRNAs after RMRP knockdown in HCCC‐9810. Sequencing results showed that the miRNA expression profile varied with RMRP expression, among which there were well‐investigated miR‐33a, miR‐186, miR‐17 and miR‐155 . GO and KEGG analysis of the altered microRNA expression profile showed that these altered miRNAs, as a whole, point to a variety of important function pathways.…”

Section: Discussionmentioning

confidence: 99%

Long noncoding‐RNA component of mitochondrial RNA processing endoribonuclease is involved in the progression of cholangiocarcinoma by regulating microRNA‐217

Tang

Wang

et al. 2019

Cancer Science

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Cholangiocarcinoma (CCA) is a malignant tumor originating from bile duct epithelium and its incidence is increasing year by year. In recent years, long noncoding RNAs (lncRNAs) have been found to play an important role in the occurrence and progression of malignant tumors. In the present study, for the first time, abnormal expression of lnc‐RNA component of mitochondrial RNA processing endoribonuclease (RMRP) and its possible role in CCA were found. We explored the effects of RMRP on various behaviors of CCA cells in vitro and in vivo. In addition, by second‐generation sequencing, we explored the microRNA expression profiles that RMRP may affect in the HCCC‐9810 cell line. We also validated and explored the role of microRNA‐217 (miR‐217) with high differential expression by in vitro experiments. Our findings indicated that RMRP can play a part in promoting cancer by regulating the expression of miR‐217. RMRP is involved in the progression of CCA and can be a novel indicator of poor prognosis in patients with CCA.

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Section: Discussionmentioning

confidence: 99%

Long noncoding‐RNA component of mitochondrial RNA processing endoribonuclease is involved in the progression of cholangiocarcinoma by regulating microRNA‐217

Tang

Wang

et al. 2019

Cancer Science

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“…For instance, CCAT1 promotes the proliferation migration and invasion of human retinoblastoma and reduces cell apoptosis through negative regulation of miR‐218‐5p in SO‐RB50 and Y79 cells (Zhang, Zhong et al, ). LncRNA DANCR is over‐expressed in osteosarcoma cell proliferation, migration, invasion, and xenograft tumor growth in vitro and in vivo and regulates osteosarcoma stemness features by upregulating AXL via miR‐33a‐5p inhibition (Jiang et al, ). Besides, Zhang, Zhu et al () have reported that miR‐613 suppresses retinoblastoma cell proliferation, invasion, and tumor formation by targeting E2F5, which is closely correlated with our study.…”

Section: Discussionmentioning

confidence: 99%

Long noncoding RNA DANCR aggravates retinoblastoma through miR‐34c and miR‐613 by targeting MMP‐9

Wang

Yang

2018

Journal Cellular Physiology

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Long non-coding RNAs (lncRNAs) have been identified to play vital roles in cancers, including human retinoblastoma (RB). However, the deepgoing mechanism is still ambiguous. In present study, we investigate the biological role of lncRNA DANCR (differentiation antagonizing non-protein coding RNA) in carcinogenesis of RB. Results revealed that DANCR was up-regulated in RB tissue and cell lines. Moreover, the ectopic overexpression of DANCR indicated poor overall survivals and disease free survival (DFS) for RB patients. In vitro and in vivo experiments, DANCR knockdown suppress the proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) correlated protein (N-cadherin, Vimentin) of RB cells. Bioinformatics analysis predicted that miR-34c and miR-613 targeted with 3'-UTR of DANCR, besides, miR-34c and miR-613 also targeted with 3'-UTR of MMP-9, which was validated by luciferase reporter assay. Functional experiments demonstrated that miR-34c and miR-613 could reverse the oncogenic function of DANCR in RB tumorigenesis. In conclusion, our results reveal that DANCR function as competing endogenous RNA (ceRNA) for miR-34c and miR-613 to modulate progression and metastasis in RB oncogenesis via targeting MMP-9, presenting the in-depth regulation of DANCR in RB and providing a novel insight for ceRNA mechanism for RB.

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“…38 In a recent study, miR-33a was found to be inhibited in cancer stem cells by long noncoding RNA DANCR, which induces tumor development and cancer stemness properties in osteosarcoma by eventually activating the phosphatidylinositol 3 0 -kinase (PI3K)-Akt signaling pathway. 39 Moreover, attenuated miR-33a expression was implicated in the chemoresistance of Lgr5-positive hepatocellular carcinoma cancer stem cells, through upregulation of ABCA1, which is a known direct target of miR-33a. 40 These findings all together imply involvement of miR-33a in carcinogenesis and acquisition of cancer stemness features.…”

Section: Discussionmentioning

confidence: 99%

Antiproliferative potential of miR‐33a in laryngeal cancer Hep‐2 cells via targeting PIM1

Karataş

2018

Head & Neck

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lncRNA DANCR promotes tumor progression and cancer stemness features in osteosarcoma by upregulating AXL via miR-33a-5p inhibition

Cited by 190 publications

References 30 publications

Long noncoding‐RNA component of mitochondrial RNA processing endoribonuclease is involved in the progression of cholangiocarcinoma by regulating microRNA‐217

Long noncoding‐RNA component of mitochondrial RNA processing endoribonuclease is involved in the progression of cholangiocarcinoma by regulating microRNA‐217

Long noncoding RNA DANCR aggravates retinoblastoma through miR‐34c and miR‐613 by targeting MMP‐9

Antiproliferative potential of miR‐33a in laryngeal cancer Hep‐2 cells via targeting PIM1

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