LncRNA HOXA11-AS Promotes Proliferation and Invasion of Gastric Cancer by Scaffolding the Chromatin Modification Factors PRC2, LSD1, and DNMT1

Sun, Ming; Nie, Fengqi; Wang, Yunfei; Zhang, Zhihong; Hou, Jiakai; He, Dandan; Xie, Min; Xu, Lin; De, Wei; Wang, Zhaoxia; Wang, Jun

doi:10.1158/0008-5472.can-16-0356

Cited by 437 publications

(395 citation statements)

References 54 publications

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“…Here, RNA pull down and RIP assays demastrated that Linc00441 could bind to DNMT1 in GC cells ( Figure 5). As well as our findings, Sun et al have found that lncRNA HOXA11-AS stimulates cell proliferation and metastasis of GC via scaffolding the chromatin modification factors PRC2, LSD1 and DNMT1 [32]. Wang et al have found that lncRNA Dum inhibits Dppa2, its adjacent gene, in cis by recruiting DNMT1, DNMT3A and DNMT3B [33].…”

Section: Discussionsupporting

confidence: 89%

Linc00441 interacts with DNMT1 to regulate RB1 gene methylation and expression in gastric cancer

Zhou

Shi

et al. 2018

Oncotarget

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Section: Discussionsupporting

confidence: 89%

Linc00441 interacts with DNMT1 to regulate RB1 gene methylation and expression in gastric cancer

Zhou

Shi

et al. 2018

Oncotarget

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“…S7A). Some lncRNAs affect the expression of protein-coding genes by interacting with the PRC2 subunit EZH2 (32)(33)(34). In starBase v2.0, we found that EZH2 in murine embryonic stem cells could bind to Neat1 (http:// starbase.sysu.edu.cn/; Supplementary Fig.…”

Section: Neat1 Interacts With Ezh2mentioning

confidence: 99%

Long Noncoding RNA NEAT1, Regulated by the EGFR Pathway, Contributes to Glioblastoma Progression Through the WNT/β-Catenin Pathway by Scaffolding EZH2

Chen

Cai

Wang³

et al. 2018

Clinical Cancer Research

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291

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Purpose: Long noncoding RNAs have been implicated in gliomagenesis, but their mechanisms of action are mainly undocumented. Through public glioma mRNA expression data sets, we found that NEAT1 was a potential oncogene. We systematically analyzed the clinical significance and mechanism of NEAT1 in glioblastoma.Experimental Design: Initially, we evaluated whether NEAT1 expression levels could be regulated by EGFR pathway activity. We subsequently evaluated the effect of NEAT1 on the WNT/ b-catenin pathway and its target binding gene. The animal model supported the experimental findings.Results: We found that NEAT1 levels were regulated by EGFR pathway activity, which was mediated by STAT3 and NFkB (p65) downstream of the EGFR pathway. Moreover, we found that NEAT1 was critical for glioma cell growth and invasion by increasing b-catenin nuclear transport and downregulating ICAT, GSK3B, and Axin2. Taken together, we found that NEAT1 could bind to EZH2 and mediate the trimethylation of H3K27 in their promoters. NEAT1 depletion also inhibited GBM cell growth and invasion in the intracranial animal model.Conclusions: The EGFR/NEAT1/EZH2/b-catenin axis serves as a critical effector of tumorigenesis and progression, suggesting new therapeutic directions in glioblastoma. Clin Cancer Res; 1-12.Ó2017 AACR.

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“…Sun et al reported that patients with high HOXA11‐AS expression had a shorter survival and poorer prognosis 24. HOXA11‐AS alterations showed a complexly integrated phenotype affecting cell growth, migration, invasion, and apoptosis both in vitro as well as in vivo.…”

Section: Hoxa11‐as Lncrna In Human Cancersmentioning

confidence: 99%

HOXA11 antisense long noncoding RNA (HOXA11‐AS): A promising lncRNA in human cancers

Zhou

Xie

et al. 2018

Cancer Medicine

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The cancers are the leading cause of disease‐related deaths worldwide with a high risk of morbidity and mortality. Long noncoding RNAs (lncRNAs) play a critical role in a wide range of biological processes, including tumorigenesis. HOXA11‐AS (NCRNA00076), the antisense strands of HOXA11 gene, was initially revealed in a mouse embryonic cDNA library in 2009 and it was a fairly novel lncRNA. This review summarized the advanced research progression concerning the expression and role of HOXA11‐AS in different human malignancies. The expression of HOXA11‐AS is aberrantly altered in many cancers, either as a tumor suppressor or as a tumor accelerator. The different underlying mechanism of HOXA11‐AS in different cancers (including, nonsmall cell lung cancers, osteosarcoma, uveal melanoma, glioma, hepatocellular carcinoma, gastric cancer, breast cancer, cervical cancer, ovarian cancer, colorectal cancer, ovarian cancer, and glioblastoma) was also detailed. These findings lead us to conclude that HOXA11‐AS participate in the complex network of cancers and plays an important role in the tumorigenesis and progression. Functional HOXA11‐AS could be a promising biomarker for early detection as well as prognosis evaluation in cancer patients. Future HOXA11‐AS‐targeted intervention may become a valuable novel therapeutic tool, improving the clinical management of cancers.

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LncRNA HOXA11-AS Promotes Proliferation and Invasion of Gastric Cancer by Scaffolding the Chromatin Modification Factors PRC2, LSD1, and DNMT1

Cited by 437 publications

References 54 publications

Linc00441 interacts with DNMT1 to regulate RB1 gene methylation and expression in gastric cancer

Linc00441 interacts with DNMT1 to regulate RB1 gene methylation and expression in gastric cancer

Long Noncoding RNA NEAT1, Regulated by the EGFR Pathway, Contributes to Glioblastoma Progression Through the WNT/β-Catenin Pathway by Scaffolding EZH2

HOXA11 antisense long noncoding RNA (HOXA11‐AS): A promising lncRNA in human cancers

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