LncRNA HOXB-AS3 promotes growth, invasion and migration of epithelial ovarian cancer by altering glycolysis

Xu, Sujuan; Jia, Genmei; Zhang, Huilin; Wang, Luyao; Cong, Yu; Lv, Mingming; Xu, Juan; Ruan, Hongjie; Jia, Xuemei; Xu, Pengfei; Wang, Yingwei

doi:10.1016/j.lfs.2020.118636

Cited by 24 publications

(26 citation statements)

References 32 publications

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“…For example, HOXB-AS3 plays an oncogenic role in lung cancer, acute myeloid leukemia (AML), hepatoma, and epithelial ovarian cancer (EOC). [166][167][168][169] Xu et al reported that HOXB-AS3 promotes EOC glycolysis by altering LDHA expression. 166 However, Huang et al reported that HOXB-AS3 is downregulated in colon cancer and encodes a peptide to inhibit glycolysis.…”

Section: Perspectives: the Potential Therapeutic Role Of Lncrnasmentioning

confidence: 99%

“…[166][167][168][169] Xu et al reported that HOXB-AS3 promotes EOC glycolysis by altering LDHA expression. 166 However, Huang et al reported that HOXB-AS3 is downregulated in colon cancer and encodes a peptide to inhibit glycolysis. 72 Papaioannou et al proposed that the HOXB-AS3 transcript variant in AML cells presents limited overlap with its variant that is downregulated in colon cancer cells.…”

Section: Perspectives: the Potential Therapeutic Role Of Lncrnasmentioning

confidence: 99%

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Regulatory Mechanisms of LncRNAs in Cancer Glycolysis: Facts and Perspectives

Huang¹,

Zhu²,

Liang³

et al. 2021

CMAR

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Cancer cells exhibit distinct metabolic characteristics that employ glycolysis to provide energy and intermediary metabolites. This aberrant metabolic phenotype favors cancer progression. LncRNAs are transcripts longer than 200 nucleotides that do not encode proteins. LncRNAs contribute to cancer progression and therapeutic resistance and affect aerobic glycolysis via multiple mechanisms, including modulating glycolytic transporters and enzymes. Further, dysregulated signaling pathways are vital for glycolysis. In this review, we highlight regulatory mechanisms for lncRNAs in aerobic glycolysis that provide novel insights into cancer development. Moreover, a comprehensive understanding of the regulatory mechanisms of lncRNAs in aerobic glycolysis can provide new strategies for clinical cancer management.

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Section: Perspectives: the Potential Therapeutic Role Of Lncrnasmentioning

confidence: 99%

Section: Perspectives: the Potential Therapeutic Role Of Lncrnasmentioning

confidence: 99%

Regulatory Mechanisms of LncRNAs in Cancer Glycolysis: Facts and Perspectives

Huang¹,

Zhu²,

Liang³

et al. 2021

CMAR

View full text Add to dashboard Cite

show abstract

“…In the following studies, although the effects of lncRNA HOXB-AS3 on other tumors were also reported, it is interesting to note that the studies were only at the RNA level and mostly showed cancer-promoting properties. For example, low expression of HOXB-AS3 can reduce the expression of lactate dehydrogenase A and extracellular acidification rate through the sponge miR-378a-3p, thus promoting the growth, invasion and migration of epithelial ovarian cancer ( 81 ). The expression of HOXB-AS3 was significantly increased in non-small-cell lung carcinoma tissues and cells, and the activation of PI3K-AKT increased the proliferation, migration and invasion of lung cancer ( 82 ).…”

Section: Lncrna Encoded Small Peptidesmentioning

confidence: 99%

Functional Peptides Encoded by Long Non-Coding RNAs in Gastrointestinal Cancer

et al. 2021

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Gastrointestinal cancer is by far the most common malignancy and the most common cause of cancer-related deaths worldwide. Recent studies have shown that long non-coding RNAs (lncRNAs) play an important role in the epigenetic regulation of cancer cells and regulate tumor progression by affecting chromatin modifications, gene transcription, translation, and sponge to miRNAs. In particular, lncRNA has recently been found to possess open reading frame (ORF), which can encode functional small peptides or proteins. These peptides interact with its targets to regulate transcription or the signal axis, thus promoting or inhibiting the occurrence and development of tumors. In this review, we summarize the involvement of lncRNAs and the function of lncRNAs encoded small peptides in gastrointestinal cancer.

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“…HOXB-AS3 was previously reported to encode a micro-peptide and to suppress tumor progression in colon cancer ( 9 ). However, biofunction varies in different types of cancer ( 10 , 11 ). Its potential function and underlying mechanism in OSCC are still unknown.…”

Section: Introductionmentioning

confidence: 99%

A micro‑peptide encoded by HOXB‑AS3 promotes the proliferation and viability of oral squamous cell carcinoma cell lines by directly binding with IGF2BP2 to stabilize c‑Myc

et al. 2021

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HOXB-AS3 is a long non-coding RNA and recent studies have shown that the HOXB-AS3-encoded micro-peptide was associated with the progression of colon cancer tumorigenesis; however, the biofunction of HOXB-AS3 varies in different types of cancer and the potential function in oral squamous cell carcinoma (OSCC) is still unknown. The Cancer Genome Atlas (TCGA) database was searched and the expression patterns of HOXB-AS3 in head and neck carcinoma were analyzed. Reverse transcription-quantitative PCR and western blot analysis was used to measure the mRNA and protein expression level of HOXB-AS3 in patients with OSCC, respectively. Next, HOXB-AS3 was knocked down in 2 OSCC cell lines to investigate the biological function of the HOXB-AS3-encoded protein using a Cell Counting Kit-8 and colony formation assays. To further identify the potential mechanism of the HOXB-AS3-encoded protein, co-immunoprecipitation was also used to detect the interaction between HOXB-AS3 and IGF2BP2, while HOXB-AS3 was re-expressed to determine whether the HOXB-AS3-encoded protein and not HOXB-AS3 exerted its function in OSCC. HOXB-AS3 was upregulated in OSCC tissues, in both TCGA database and in patients with OSCC recruited into the present study. HOXB-AS3 was associated with poor prognosis in OSCC. The proliferation and viability decreased in the 2 OSCC cell lines following knock down of HOXB-AS3. HOXB-AS3 was also found to encode a protein that directly interacted with IGF2BP2 and thereby promoted the stability of c-myc. Taken together, the results from the present study indicated that increased HOXB-AS3 expression was associated with poor prognosis in OSCC. This indicated that HOXB-AS3 and its encoded protein promoted OSCC cell proliferation and viability by maintaining c-Myc mRNA stability by directly binding to IGF2BP2.

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LncRNA HOXB-AS3 promotes growth, invasion and migration of epithelial ovarian cancer by altering glycolysis

Cited by 24 publications

References 32 publications

Regulatory Mechanisms of LncRNAs in Cancer Glycolysis: Facts and Perspectives

Regulatory Mechanisms of LncRNAs in Cancer Glycolysis: Facts and Perspectives

Functional Peptides Encoded by Long Non-Coding RNAs in Gastrointestinal Cancer

A micro‑peptide encoded by HOXB‑AS3 promotes the proliferation and viability of oral squamous cell carcinoma cell lines by directly binding with IGF2BP2 to stabilize c‑Myc

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