LncRNA LINC00473 is involved in the progression of invasive pituitary adenoma by upregulating KMT5A via ceRNA-mediated miR-502-3p evasion

Li, Junjun; Yuan, Qian; Zhang, Chao; Wang, Wei; Qiao, Yisheng; Song, Hao; Li, Liyan; Guo, Jinming; Lü, Di; Deng, Xingli

doi:10.1038/s41419-021-03861-y

Cited by 23 publications

(21 citation statements)

References 56 publications

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“…As one of the most common primary brain tumours, pituitary adenoma (PA) occurs in ∼16% of intracranial tumour cases worldwide [ 1 , 2 ]. Pituitary adenoma is clinically defined as invasive pituitary adenoma (IPA) or noninvasive pituitary adenoma (NIPA), and approximately 35% of pituitary adenomas are IPA [ 3 ], which exhibit invasive behaviours and actively invade surrounding tissues [ 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

Alterations of the Gut Microbiome in Patients With Pituitary Adenoma

Hu¹,

Yang²,

Chen³

et al. 2022

Pathol. Oncol. Res.

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Pituitary adenoma (PA) includes invasive pituitary adenoma (IPA) and noninvasive pituitary adenoma (NIPA), which are associated with the endocrine system. The gut microbiome plays an important role in human metabolism, but the association between the gut microbiome and pituitary adenoma remains unclear. A total of 44 subjects were enrolled in this study. Of these, 29 PA patients were further divided into IPA patients (n = 13) and NIPA patients (n = 16), while 15 healthy age-matched subjects were defined as control subjects. We collected faecal samples and characterized the gut microbial profiles by metagenomic sequencing using the Illumina X-ten platform. PLS-DA showed different microbial clusters among the three groups, and slightly different microbial ecological networks were observed. LEfSe analysis revealed significant alterations in the microbial community among PA patients. In particular, the enrichment of Clostridium innocuum, along with the reduced abundance of Oscillibacter sp. 57_20 and Fusobacterium mortiferum, were observed both in the IPA and NIPA groups compared to the control group. Moreover, PA patients could be effectively classified based on these bacteria using a support vector machine algorithm. In summary, this study demonstrated significant differences in the gut microbiome between PA patients and healthy controls. Future mechanistic experiments are needed to determine whether such alterations are a cause or consequence of pituitary adenoma.

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Section: Introductionmentioning

confidence: 99%

Alterations of the Gut Microbiome in Patients With Pituitary Adenoma

Hu¹,

Yang²,

Chen³

et al. 2022

Pathol. Oncol. Res.

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“…There is increasing evidence that the ceRNA regulatory network plays a role in cancer development and occurrence [12][13][14]. It might be possible to uncover the mechanism by which CASC1 influences bladder cancer progression by studying the ceRNA network.…”

Section: Introductionmentioning

confidence: 99%

CASC1 Expression in Bladder Cancer Is Regulated by Exosomal miRNA-150: A Comprehensive Pan-Cancer and Bioinformatics Study

Luo

et al. 2022

Computational and Mathematical Methods in Medicine

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This study explored the role of cancer susceptibility 1 (CASC1) in tumorigenesis and development as well as the key pathways affecting bladder cancer progression. CASC1 was examined in various normal tissues in humans using the HPA database to quantify its expression level and subcellular localization. CASC1 is abundantly expressed in tumor tissues, primarily in cytoplasmic vesicles and stroma. TIMER2 was used to analyze the correlation between CASC1 expression levels and the types of infiltrates associated with immune cells and immunosuppressive cells. MDSC, Treg, M2, and CAF were significantly correlated with CASC1 expression in various tumors. Comparing patients with and without CASC1 mutation, those with CASC1 mutation had worse overall survival, progression-free survival, and disease-free survival. The correlation between has-miR-150 and CASC1 (for the case of bladder cancer) was then analyzed, and the related ceRNA network was mapped. A negative relationship between CASC1 expression and has-miR-150 expression was found in cases of bladder cancer. And the presence of miR-150-targeted CASC1 may be associated with bladder cancer progression. CASC1 is expressed at elevated levels in various tumor tissues, and it is associated with tumorigenesis and development. Exosomes containing miR-150-targeted CASC1 may affect the progression of bladder cancer.

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“…The mechanisms associated with the invasion of PAs and novel biomarkers for the diagnosis of IPAs remain largely unclear. Recently, several lncRNAs, including small nucleolar RNA host gene 1 (SNHG1), H19, colon cancer associated transcript 2, LINC00473, and antisense noncoding RNA in the INK4 locus, were reported to participate in the proliferation, progression, and invasion of PAs [ 28 – 31 ]. However, the lncRNA–mRNA expression patterns and dysregulated lncRNAs in IPAs remained to be investigated.…”

Section: Discussionmentioning

confidence: 99%

lncRNA–mRNA Expression Patterns in Invasive Pituitary Adenomas: A Microarray Analysis

Peng

Wang

et al. 2022

BioMed Research International

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Background. Long noncoding RNAs (lncRNAs) play important roles in the tumorigenesis and progression of various cancer types; however, their roles in the development of invasive pituitary adenomas (PAs) remain to be investigated. Methods. lncRNA microarray analysis was performed for three invasive and three noninvasive PAs. Gene Ontology (GO) enrichment and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis were performed, and coexpression networks between lncRNA and mRNA were constructed. Furthermore, three differentially expressed lncRNAs were selected for validation in PA samples by real-time quantitative reverse transcription polymerase chain reaction (qRT-PCR). The diagnostic values of these three lncRNAs were further evaluated by a receiver operating characteristic (ROC) curve analysis. Results. A total of 8872 lncRNAs were identified in invasive and paired noninvasive PAs via lncRNA microarray analysis. Among these, the differentially expressed lncRNAs included 81 that were upregulated and 165 that were downregulated. GO enrichment and KEGG pathway analysis showed that these differentially expressed lncRNAs were associated with the posttranslational modifications of proteins. Furthermore, we performed target gene prediction and coexpression analysis. The interrelationships between the significantly differentially expressed lncRNAs and mRNAs were identified. Additionally, three differentially expressed lncRNAs were selected for validation in 41 PA samples by qRT-PCR. The expression levels of FAM182B, LOC105371531, and LOC105375785 were significantly lower in the invasive PAs than in the noninvasive PAs ( P < 0.05 ). These results were consistent with the microarray data. ROC curve analysis suggested that the expression levels of FAM182B and LOC105375785 could be used to distinguish invasive PAs from noninvasive PAs. Conclusion. Our findings demonstrated the expression patterns of lncRNAs in invasive PAs. FAM182B and LOC105375785 may be involved in the invasiveness of PAs and serve as new candidate biomarkers for the diagnosis of invasive PAs.

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LncRNA LINC00473 is involved in the progression of invasive pituitary adenoma by upregulating KMT5A via ceRNA-mediated miR-502-3p evasion

Cited by 23 publications

References 56 publications

Alterations of the Gut Microbiome in Patients With Pituitary Adenoma

Alterations of the Gut Microbiome in Patients With Pituitary Adenoma

CASC1 Expression in Bladder Cancer Is Regulated by Exosomal miRNA-150: A Comprehensive Pan-Cancer and Bioinformatics Study

lncRNA–mRNA Expression Patterns in Invasive Pituitary Adenomas: A Microarray Analysis

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